CAREER: Microfluidic 3D Apoptosis Cell Arrays

该职业奖将导致高通量功能性微流控平台和独特细胞结构的发展，从而可以研究与细胞死亡途径（如凋亡）相关的信号的动态读数。这项工作结合了生物力学等工程方面的进展，以及分子和细胞生物学和药理学方面的最新知识。该平台将用于研究抗癌药物的作用机制，并最终用于快速药物筛选。这项研究将缩短新药的开发时间，不仅是针对癌症，还有可能针对各种疾病。该奖项的教育目标是增加研究机会，并增加来自代表性不足群体的学生进入生物技术和生物工程专业队伍的人数，将通过以下方式实现：(i)为高中生提供暑期研究经验；（ii）增加工程专业本科生的留用；（iii）联络业界，推动招聘生物医学工程专业毕业生；（iv）透过将最新的生物科技纳入学院生物工程课程，以及提供本科生研究机会，提升生物工程专业学生在生物科技/生物工程专业就业市场的竞争力。对于高中生来说，研究经历将建立他们的科学知识，并鼓励他们攻读BME专业。

This CAREER award will lead to the development of a high-throughput functional microfluidic platform and unique cellular constructs such that dynamic readouts of signaling associated with cell death pathways such as apoptosis can be investigated. The work combines advances in engineering such as BioMEMS with current knowledge in molecular and cell biology and pharmacology. This platform will be used to examine the mechanism of action of anticancer drugs, and ultimately be used in rapid drug screening. The research will lead to a reduction in time to development of new drugs, not just for cancer, but potentially for a variety of diseases.The educational goals of this award, to enhance research opportunities and increase the number of students from underrepresented groups entering the professional workforce of biotechnology and bioengineering, will be achieved by (i) offering summer research experiences to high school students; (ii) increasing the retention of undergraduate engineering students; (iii) reaching out to industry to promote recruitment of biomedical engineering (BME) graduates; and (iv) enhancing the BME students' competitiveness in the job market of biotech/bioengineering by incorporating up-to-date biotechnologies into the CCNY BME curriculum and providing undergraduate research opportunities. For high school students, the research experiences will build their scientific knowledge and encourage them to pursue the BME major.