CAREER: Microfluidic 3D Apoptosis Cell Arrays

该CAREER奖项将导致高通量功能微流体平台和独特细胞构建体的开发，从而可以研究与细胞死亡途径（如凋亡）相关的信号传导的动态读数。 这项工作结合了BioMEMS等工程技术的进步，以及分子和细胞生物学和药理学的现有知识。该平台将用于研究抗癌药物的作用机制，并最终用于快速药物筛选。 这项研究将导致新药开发时间的缩短，不仅是癌症，而且可能是各种疾病。该奖项的教育目标是增加研究机会，增加来自代表性不足群体的学生进入生物技术和生物工程专业劳动力的人数，将通过以下方式实现：（i）为高中生提供暑期研究经验;（ii）增加工程学学士学位学生的留港率;（iii）主动与业界接触，鼓励业界招聘生物医学工程毕业生;及（iv）把最新的生物技术纳入纽约市立大学生物医学工程课程，并提供学士学位研究机会，以提高生物医学工程学生在生物技术/生物工程就业市场的竞争力。对于高中生来说，研究经验将建立他们的科学知识，并鼓励他们追求BME专业。

This CAREER award will lead to the development of a high-throughput functional microfluidic platform and unique cellular constructs such that dynamic readouts of signaling associated with cell death pathways such as apoptosis can be investigated. The work combines advances in engineering such as BioMEMS with current knowledge in molecular and cell biology and pharmacology. This platform will be used to examine the mechanism of action of anticancer drugs, and ultimately be used in rapid drug screening. The research will lead to a reduction in time to development of new drugs, not just for cancer, but potentially for a variety of diseases.The educational goals of this award, to enhance research opportunities and increase the number of students from underrepresented groups entering the professional workforce of biotechnology and bioengineering, will be achieved by (i) offering summer research experiences to high school students; (ii) increasing the retention of undergraduate engineering students; (iii) reaching out to industry to promote recruitment of biomedical engineering (BME) graduates; and (iv) enhancing the BME students' competitiveness in the job market of biotech/bioengineering by incorporating up-to-date biotechnologies into the CCNY BME curriculum and providing undergraduate research opportunities. For high school students, the research experiences will build their scientific knowledge and encourage them to pursue the BME major.