2011 Physical Virology Gordon-Keenan Research Seminar and the Gordon Research Conference

2011年物理病毒学戈登-基南研究研讨会和戈登研究会议

• 批准号: 1061223
• 负责人: Bogdan Dragnea
• 金额: $ 0.56万
• 依托单位: Gordon Research Conferences
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-12-01 至 2011-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1061223&HistoricalAwards=false
• 关键词: 2011; Physical; Virology; Gordon; Keenan

ID: MPS/DMR/BMAT(7623) 1061223 PI: Dragnea, Bogdan ORG: University of IndianaTitle: 2011 Physical Virology GRC (Gordon Research Conference)INTELLECTUAL MERIT: Viruses have many features that are uniquely relevant to nanobiotechnology. To date, it has not been feasible to create synthetic nanoparticles of comparable beauty and utility. Viral particles have been found to be suitable building blocks for several reasons: (1) viral capsids are extremely robust and can be produced in large quantities with ease, (2) the particles self-assemble into monodisperse constructs with a high degree of symmetry and polyvalency, (3) they have the propensity to form regular 2D and 3D arrays, and (4) they offer programmability through genetic and chemical engineering. Combined knowledge of the structure of virus capsids at atomic resolution and the use of chimeric virus technology permits generation of virus-like particles with short antigenic peptides for potential use as vaccine candidates. The chemical addressability of capsids has led to the development of virus-based vascular imaging probes. This feature of virus-based materials, preserving the structural integrity and, thus, symmetry of the molecular scaffold, may also become relevant for the field of energy harvesting. Thus, although there is a diverse range of mechanisms used by light harvesting biological organisms, one common feature to all of them is the requirement of an electron-transfer relay system. This involves a series of chromophores arranged with nanometer precision in a regular array that enables the efficient transport of energy through a series of Förster resonance energy transfer events. The virus paradigm for molecularly accurate self-organization is under intense study in this respect as a suitable scaffold for the templating of regularly spaced chromophores to mimic a light harvesting antenna.BROADER IMPACTS: This GRC is unique in its scope and complementary to other meetings on viruses. While most traditional virology meetings are dedicated to specific systems, the Physical Virology GRC deals with the existence of universal principles of virus structure and assembly underlying the physical properties of viruses and virus-mimetic systems. It will afford an important and unique opportunity for biologists, chemists, and physicists to convene to apply their respective perspectives to the issue of viral structure and assembly as it relates to use of viruses as scaffolds for the creation of functional materials not achievable by other means. The organizers will use the funds provided to encourage the participation of younger scientists and scientists from underrepresented groups.

ID: MPS/DMR/BMAT(7623) 1061223 PI: Dragnea， Bogdan ORG: University of IndianaTitle: 2011物理病毒学GRC （Gordon Research Conference）学术价值：病毒具有许多与纳米生物技术独特相关的特征。到目前为止，还无法制造出具有同等美观和实用性的合成纳米颗粒。由于以下几个原因，病毒颗粒被发现是合适的构建模块：(1)病毒衣壳非常坚固，可以很容易地大量生产；(2)粒子自组装成具有高度对称性和多价性的单分散结构；(3)它们有形成规则的2D和3D阵列的倾向；(4)它们通过遗传和化学工程提供可编程性。在原子分辨率上对病毒衣壳结构的了解与嵌合病毒技术的使用相结合，可以产生具有短抗原肽的病毒样颗粒，这些颗粒可能用作候选疫苗。衣壳的化学可寻址性导致了基于病毒的血管成像探针的发展。病毒基材料的这一特性，保留了分子支架的结构完整性和对称性，也可能与能量收集领域相关。因此，尽管光收集生物有机体使用的机制多种多样，但它们的一个共同特征是对电子传递中继系统的要求。这涉及一系列以纳米精度排列在规则阵列中的发色团，通过一系列Förster共振能量转移事件实现能量的有效传输。在这方面，分子精确自组织的病毒范式正在被深入研究，作为一种合适的支架，用于模板规则间隔的发色团来模拟光收集天线。更广泛的影响：本次GRC的范围是独特的，是对其他病毒会议的补充。虽然大多数传统病毒学会议致力于特定系统，但物理病毒学GRC处理病毒结构和组装的普遍原理，这些原理是病毒和病毒模拟系统物理特性的基础。它将为生物学家、化学家和物理学家提供一个重要而独特的机会，让他们聚集在一起，将各自的观点应用到病毒结构和组装问题上，因为它涉及到使用病毒作为支架来创造其他方法无法实现的功能材料。组织者将利用提供的资金鼓励年轻科学家和来自代表性不足群体的科学家参与。