2011 Physical Virology Gordon-Keenan Research Seminar and the Gordon Research Conference

ID：MPS/dmr/bmat(7623)1061223 PI：Dragnea，Bogdan ORG：印度大学标题：2011年物理病毒学GRC(戈登研究会议)智力优势：病毒具有许多与纳米生物技术独特相关的特征。到目前为止，还不可能创造出具有同等美观和实用性的合成纳米颗粒。病毒颗粒被发现是合适的构建块，原因有几个：(1)病毒衣壳非常坚固，可以轻松地大量生产，(2)颗粒自组装成具有高度对称性和多价性的单分散结构，(3)它们有形成规则2D和3D阵列的倾向，以及(4)它们通过基因工程和化学工程提供可编程性。结合原子分辨率的病毒衣壳结构知识和嵌合病毒技术的使用，可以产生具有短抗原肽的病毒样颗粒，作为潜在的候选疫苗。衣壳的化学寻址能力导致了基于病毒的血管成像探针的发展。以病毒为基础的材料的这一特征，保持了分子支架的结构完整性和对称性，也可能成为能量收集领域的相关内容。因此，尽管捕光生物所使用的机制有多种，但所有这些机制都有一个共同的特点，那就是需要一个电子转移中继系统。这涉及一系列以纳米精度排列在规则阵列中的发色团，使能量能够通过一系列Förster共振能量转移事件进行有效传输。在这方面，分子精确自组织的病毒范例正在进行深入的研究，作为以规则间隔的生色团为模板来模拟捕光天线的合适支架。BROADER影响：这次GRC在其范围上是独特的，并与其他关于病毒的会议相辅相成。虽然大多数传统的病毒学会议是专门讨论特定系统的，但物理病毒学GRC涉及病毒结构和组装的普遍原则的存在，这些原则是病毒和模拟病毒系统的物理属性的基础。它将为生物学家、化学家和物理学家提供一个重要而独特的机会，让他们聚集在一起，将他们各自的观点应用到病毒结构和组装问题上，因为这涉及到使用病毒作为支架来创建功能材料，而其他方法是无法实现的。组织者将利用提供的资金鼓励年轻科学家和来自代表性不足群体的科学家参与。

ID: MPS/DMR/BMAT(7623) 1061223 PI: Dragnea, Bogdan ORG: University of IndianaTitle: 2011 Physical Virology GRC (Gordon Research Conference)INTELLECTUAL MERIT: Viruses have many features that are uniquely relevant to nanobiotechnology. To date, it has not been feasible to create synthetic nanoparticles of comparable beauty and utility. Viral particles have been found to be suitable building blocks for several reasons: (1) viral capsids are extremely robust and can be produced in large quantities with ease, (2) the particles self-assemble into monodisperse constructs with a high degree of symmetry and polyvalency, (3) they have the propensity to form regular 2D and 3D arrays, and (4) they offer programmability through genetic and chemical engineering. Combined knowledge of the structure of virus capsids at atomic resolution and the use of chimeric virus technology permits generation of virus-like particles with short antigenic peptides for potential use as vaccine candidates. The chemical addressability of capsids has led to the development of virus-based vascular imaging probes. This feature of virus-based materials, preserving the structural integrity and, thus, symmetry of the molecular scaffold, may also become relevant for the field of energy harvesting. Thus, although there is a diverse range of mechanisms used by light harvesting biological organisms, one common feature to all of them is the requirement of an electron-transfer relay system. This involves a series of chromophores arranged with nanometer precision in a regular array that enables the efficient transport of energy through a series of Förster resonance energy transfer events. The virus paradigm for molecularly accurate self-organization is under intense study in this respect as a suitable scaffold for the templating of regularly spaced chromophores to mimic a light harvesting antenna.BROADER IMPACTS: This GRC is unique in its scope and complementary to other meetings on viruses. While most traditional virology meetings are dedicated to specific systems, the Physical Virology GRC deals with the existence of universal principles of virus structure and assembly underlying the physical properties of viruses and virus-mimetic systems. It will afford an important and unique opportunity for biologists, chemists, and physicists to convene to apply their respective perspectives to the issue of viral structure and assembly as it relates to use of viruses as scaffolds for the creation of functional materials not achievable by other means. The organizers will use the funds provided to encourage the participation of younger scientists and scientists from underrepresented groups.