Super-radiant virus-like particles as targeted contrast agents for laser-guided surgery

超辐射病毒样颗粒作为激光引导手术的靶向造影剂

• 批准号: 1803440
• 负责人: Bogdan Dragnea
• 金额: $ 30万
• 依托单位: Indiana University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-06-15 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1803440&HistoricalAwards=false
• 关键词: Super; radiant; virus; like; particles

The PI will construct the smallest reported light source with emission similar to laser light. Its brightness will be at least two orders of magnitude higher than state of the art fluorescent nanoparticles of similar size. Such a nanoscopic laser source will be valuable in guiding and assisting microscopic surgery, specifically in the brain. The PI has a well-established record of mentoring and outreach. The PI will continue these activities, e.g. mentoring a summer undergraduate student during the proposed research. The small size of the nanolaser will enable accessing the spaces between cells. The high brightness will enable triggering local photochemical reactions. Such a remote light source could photo stimulate a single synapse, a step towards wireless remote information exchange between the nervous system. This could also produce chemical species which selectively destroy cancer cells targeted by the nanolaser particles. The nanolaser is a unique molecular structure, its material scaffold being a virus shell. The advantage of using such a bio-enabled approach is due to the inherited molecular precision in structural organization and from self-assembly, which occurs spontaneously from simple, benign reagents.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

PI将构建最小的光源，其发射类似于激光。它的亮度将至少比目前类似尺寸的荧光纳米粒子高两个数量级。这种纳米级的激光源在指导和辅助显微手术，特别是脑部手术方面将具有重要价值。PI在指导和推广方面有着良好的记录。PI将继续这些活动，例如在拟议的研究期间指导暑期本科生。纳米激光器的小尺寸将使其能够进入细胞之间的空间。高亮度将触发局部光化学反应。这样的远程光源可以光刺激单个突触，向神经系统之间的无线远程信息交换迈出了一步。这也可以产生化学物质，选择性地摧毁被纳米激光粒子靶向的癌细胞。纳米激光器具有独特的分子结构，其材料支架是病毒外壳。使用这种生物激活方法的优势是由于结构组织和自组装中遗传的分子精度，这是由简单，良性试剂自发发生的。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Virus Assembly Pathways: Straying Away but Not Too Far

• DOI: 10.1002/smll.202004475
• 发表时间: 2020-11-25
• 期刊: SMALL
• 影响因子: 13.3
• 作者: Bond, Kevin;Tsvetkova, Irina B.;Dragnea, Bogdan
• 通讯作者: Dragnea, Bogdan

Radiation Brightening from Virus-like Particles

病毒样颗粒的辐射增亮

• DOI: 10.1021/acsnano.9b04786
• 发表时间: 2019
• 期刊: ACS Nano
• 影响因子: 17.1
• 作者: Tsvetkova, Irina B.;Anil Sushma, Arathi;Wang, Joseph Che-Yen;Schaich, William L.;Dragnea, Bogdan
• 通讯作者: Dragnea, Bogdan

Watching a virus grow

观察病毒的生长

• DOI: 10.1073/pnas.1915986116
• 发表时间: 2019
• 期刊: Proceedings of the National Academy of Sciences
• 作者: Dragnea, Bogdan

Modelling virus contact mechanics under atomic force imaging conditions

• DOI: 10.1080/00036811.2022.2044027
• 发表时间: 2021-12
• 期刊: Applicable Analysis
• 影响因子: 1.1
• 作者: Paolo Piersanti;Kristen L. White;B. Dragnea;R. Temam

A Laboratory Model for Virus Particle Nanoindentation

病毒颗粒纳米压痕的实验室模型

• DOI: 10.35459/tbp.2019.000106
• 发表时间: 2020
• 期刊: The Biophysicist
• 作者: Thompson, William C.;Cattani, Angela J.;Lee, Olive;Ma, Xiang;Tsvetkova, Irina B.;Dragnea, Bogdan
• 通讯作者: Dragnea, Bogdan