Dehydroabietinal Signaling in Plant Defense

植物防御中的脱氢枞树信号

• 批准号: 1121570
• 负责人: Jyoti Shah
• 金额: $ 20万
• 依托单位: University of North Texas
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1121570&HistoricalAwards=false
• 关键词: Dehydroabietinal; Signaling; Plant; Defense

The ability to induce defense systemically after a local infection allows plants to control disease spread to additional organs and ward off new infections. Dehydroabietinal, an abietane diterpenoid that is produced by a variety of plants, is a potent activator of systemic disease resistance, which is an inducible defense mechanism activated in the foliage in response to a local infection. The goal of this project is to characterize the involvement of dehydroabietinal as a long-distance signaling molecule in plant defense. A combination of genetic, biochemical, and molecular approaches will be utilized to accomplish this goal. The proposed activity will enhance our understanding of long-distance communication in plant defense and provide important insights into the function of abietane diterpenoids in plants. Broader Impacts: This project will support the research and training of three graduate and two undergraduate students, and a postdoctoral fellow. They will receive training in plant biochemistry, molecular biology, genetics, organic chemistry, and mass spectrometry. In addition, through the instructional activities of the PI and Co-PIs, this project will bring current knowledge of plant signaling, secondary metabolism, and stress response, in addition to organic synthesis and mass-spectrometry techniques, into the classroom. The project will also provide opportunities to train high school students and future science teachers, and broaden the participation of underrepresented groups in research through several programs that are in place at the University of North Texas. This project will potentially benefit society at large by identifying steps in plant metabolism/signaling that mediate defense against pathogens. In the future these steps could be targeted for augmenting disease resistance in plants and thus enhance the quality and productivity of plants, and by way of limiting the need for toxic chemicals to protect plants, also benefit the environment and public health.

在局部感染后诱导系统防御的能力使植物能够控制疾病传播到其他器官并抵御新的感染。脱氢松香醛是一种由多种植物产生的松香烷类二萜，是系统抗病性的有效激活剂，这是响应局部感染而在叶子中激活的诱导型防御机制。 该项目的目标是表征脱氢松香醛作为长距离信号分子参与植物防御。 将利用遗传、生物化学和分子方法的组合来实现这一目标。 该活性将增强我们对植物防御中的远距离通信的理解，并为研究松香烷二萜类化合物在植物中的功能提供重要见解。 更广泛的影响：该项目将支持三名研究生和两名本科生以及一名博士后研究员的研究和培训。 他们将接受植物生物化学、分子生物学、遗传学、有机化学和质谱学方面的培训。 此外，通过PI和Co-PI的教学活动，该项目将把植物信号传导，次生代谢和应激反应的现有知识，以及有机合成和质谱技术带入课堂。该项目还将提供培训高中学生和未来科学教师的机会，并通过北德克萨斯大学的几个项目扩大代表性不足的群体在研究中的参与。 该项目将通过确定植物代谢/信号传导中介导防御病原体的步骤来潜在地造福整个社会。 未来，这些步骤可以用于增强植物的抗病性，从而提高植物的质量和生产力，并通过限制对有毒化学品的需求来保护植物，也有利于环境和公共健康。