Structural basis of plant immune receptor signaling

植物免疫受体信号传导的结构基础

• 批准号: DP220102832
• 负责人: Prof Bostjan Kobe
• 金额: $ 36.02万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP220102832
• 关键词: Structural; basis; plant; immune; receptor

Plants detect invading pathogens and trigger immune responses in a process called “effector-triggered immunity”, in which pathogen effector (avirulence) proteins are recognized by plant resistance proteins, typically so-called “plant NLRs”. Ongoing work in the applicants’ laboratories has shown that oligomerization into “resistosomes” and NAD+ (nicotinamide adenine dinucleotide) cleavage play central roles in the process. Building on these data, the project aims to characterize the structures of the signaling molecules resulting from TIR (Toll/interleukin-1 receptor) domain-mediated NAD+ cleavage and the structural architecture of plant NLR resistosomes. This knowledge will support the long-term objective of protecting crops from pathogens.

植物检测入侵的病原体并在一个称为“效应触发免疫”的过程中触发免疫反应，在这个过程中，病原体效应（无毒）蛋白被植物抗性蛋白识别，通常被称为“植物nlr”。申请人实验室正在进行的工作表明，寡聚化成“抵抗体”和NAD+（烟酰胺腺嘌呤二核苷酸）切割在这一过程中起着核心作用。基于这些数据，该项目旨在表征由TIR （Toll/白细胞介素-1受体）结构域介导的NAD+切割和植物NLR抗性小体的结构所产生的信号分子的结构。这些知识将支持保护作物免受病原体侵害的长期目标。