CAREER: New Reagents and Strategies for Catalytic Nucleophilic Fluorination

职业：催化亲核氟化的新试剂和策略

• 批准号: 1148750
• 负责人: Abigail Doyle
• 金额: $ 55万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1148750&HistoricalAwards=false
• 关键词: CAREER; New; Reagents; Strategies; Catalytic

With this CAREER Award, the Chemical Synthesis Program is supporting the research of Professor Abigail G. Doyle of Princeton University to invent new reagents and strategies for nucleophilic fluorination. The first objective of this research is to develop Lewis base-catalyzed hydrofluorinations using benzoyl fluoride as a latent fluoride source. The second objective is to design catalytic methods for the regio- and stereoselective synthesis of allylic and benzylic fluorides. The research is expected to facilitate the discovery and manufacture of pharmaceutical agents, agrochemicals, and functional materials by enabling the preparation of novel fluorinated building blocks using inexpensive and readily available fluoride sources. Knowledge accrued through these investigations should give way to a better understanding of the impact of aliphatic fluorine substitution in biomedical and basic research and afford new opportunities for reaction design. Professor Doyle will also be initiating educational outreach projects that interweave research and teaching. The impact of the education plan will be to broaden participation in STEM fields, particularly by underrepresented minorities and women, through early engagement of these students in hands-on research activities. One program involves providing students from a Trenton-area community college that serves a diverse population, including underrepresented minorities and low-income students, the opportunity to pursue research as part of their honors chemistry curriculum in Professor Doyle's laboratory. Second, the student invited lecture series at Princeton will be expanded to include speakers from industry, primarily undergraduate institutions, and government agencies to expose students to more varied career opportunities in the STEM disciplines.

通过这项职业奖，化学合成计划正在支持普林斯顿大学的阿比盖尔·多伊尔教授的研究，以发明新的试剂和核氟化策略。这项研究的第一个目的是使用苯甲酰氟化物作为潜在氟化物来源开发刘易斯碱基催化的氢氟化。第二个目标是设计用于烯丙基和苯并氟化物的区域和立体选择合成的催化方法。这项研究有望通过使用便宜且易于可用的氟化物来源制备新颖的氟化构件，从而促进药物，农业化学和功能材料的发现和制造。通过这些调查所产生的知识应该让位于更好地理解脂肪族氟取代在生物医学和基础研究中的影响，并为反应设计提供新的机会。 Doyle教授还将启动与研究和教学交织的教育外展项目。教育计划的影响将是通过这些学生的早期参与动手研究活动来扩大对STEM领域的参与，尤其是代表性不足的少数民族和妇女。一个计划涉及为特伦顿地区社区学院提供服务，该学院为各种各样的人口提供服务，包括代表性不足的少数民族和低收入学生，这是在道尔教授实验室中进行研究的机会。其次，普林斯顿大学的学生邀请的讲座系列将扩大，包括来自行业的演讲者，主要是本科机构和政府机构，以使学生在STEM学科中接触更多不同的职业机会。