CAREER: New Reagents and Strategies for Catalytic Nucleophilic Fluorination

职业：催化亲核氟化的新试剂和策略

• 批准号: 1148750
• 负责人: Abigail Doyle
• 金额: $ 55万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1148750&HistoricalAwards=false
• 关键词: CAREER; New; Reagents; Strategies; Catalytic

With this CAREER Award, the Chemical Synthesis Program is supporting the research of Professor Abigail G. Doyle of Princeton University to invent new reagents and strategies for nucleophilic fluorination. The first objective of this research is to develop Lewis base-catalyzed hydrofluorinations using benzoyl fluoride as a latent fluoride source. The second objective is to design catalytic methods for the regio- and stereoselective synthesis of allylic and benzylic fluorides. The research is expected to facilitate the discovery and manufacture of pharmaceutical agents, agrochemicals, and functional materials by enabling the preparation of novel fluorinated building blocks using inexpensive and readily available fluoride sources. Knowledge accrued through these investigations should give way to a better understanding of the impact of aliphatic fluorine substitution in biomedical and basic research and afford new opportunities for reaction design. Professor Doyle will also be initiating educational outreach projects that interweave research and teaching. The impact of the education plan will be to broaden participation in STEM fields, particularly by underrepresented minorities and women, through early engagement of these students in hands-on research activities. One program involves providing students from a Trenton-area community college that serves a diverse population, including underrepresented minorities and low-income students, the opportunity to pursue research as part of their honors chemistry curriculum in Professor Doyle's laboratory. Second, the student invited lecture series at Princeton will be expanded to include speakers from industry, primarily undergraduate institutions, and government agencies to expose students to more varied career opportunities in the STEM disciplines.

通过这一职业奖，化学合成计划支持普林斯顿大学阿比盖尔·g·多伊尔教授发明亲核氟化新试剂和新策略的研究。本研究的第一个目的是利用苯甲酰氟作为潜在氟源，开发路易斯碱催化的氢氟化反应。第二个目标是设计区域选择性和立体选择性合成烯丙基和苯基氟化物的催化方法。预期这项研究将促进药物制剂、农用化学品和功能材料的发现和制造，使人们能够利用廉价和容易获得的氟化物来源制备新型氟化建筑材料。通过这些调查积累的知识应该让位于更好地理解脂肪族氟取代在生物医学和基础研究中的影响，并为反应设计提供新的机会。多伊尔教授还将发起将研究与教学相结合的教育推广项目。该教育计划的影响将是通过早期让这些学生参与动手研究活动，扩大STEM领域的参与，特别是少数族裔和女性。其中一个项目是为特伦顿地区的一所社区学院的学生提供机会，让他们在多伊尔教授的实验室里进行荣誉化学课程的一部分研究。该学院的学生群体包括代表性不足的少数族裔和低收入家庭的学生。其次，普林斯顿大学的学生受邀讲座系列将扩大到来自工业界、主要是本科院校和政府机构的演讲者，让学生接触到STEM学科中更多样化的职业机会。