MRI: Upgrade of a 500 MHz Nuclear Magnetic Resonance Spectrometer

MRI：500 MHz 核磁共振波谱仪的升级

• 批准号: 9977422
• 负责人: Cynthia Larive
• 金额: $ 19.72万
• 依托单位: University of Kansas Center for Research Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9977422&HistoricalAwards=false
• 关键词: MRI; Upgrade; 500; MHz; Nuclear

With this award from the Chemistry Research Instrumentation and Facilities (CRIF) and Major Research Instrumentation Programs, the Department of Chemistry at the University of Kansas will acquire an upgrade of a 500 MHz NMR Spectrometer. This equipment will enhance research on structural studies of hemoprotein models; the development of synthetic systems to study nucleation of peptide helices and sheets; the development and characterization of DNA polymerase photoaffinity probes; synthesis of asymmetric P- and S-containing organic compounds; the study of hydrophobically-driven peptide aggregation; characterization of metal complexation and aggregate formation by humic and fulvic acids; and the development of chemical strategies for improving bioavailability of peptidomimetics through structural studies. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.

有了化学研究仪器和设施（CRIF）和主要研究仪器计划的这一奖项，堪萨斯大学化学系将获得500 MHz NMR光谱仪的升级。这一设备将加强血红素蛋白模型结构研究;开发研究肽螺旋和片成核的合成系统;开发DNA聚合酶光亲和探针并确定其特性;合成不对称含磷和硫的有机化合物;研究疏水驱动的肽聚集;确定金属络合和腐殖酸和富里酸聚集形成的特性;以及通过结构研究开发用于改善肽模拟物生物利用度的化学策略。 核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱分析技术是必不可少的。这些NMR研究的结果在聚合物、催化和生物学等领域都很有用。