Thermal Properties in Biomaterials: The Need for Microscale Measurement in Thin Tissue Systems.

生物材料的热性能：薄组织系统中微尺度测量的需要。

• 批准号: 1236760
• 负责人: John Bischof
• 金额: $ 32.47万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1236760&HistoricalAwards=false
• 关键词: Thermal; Properties; Biomaterials; Need; Microscale

CBET 1236760PI: BischofThermal transport measurement and modeling in tissues is of increasing importance in cardiovascular biomedicine such as focal therapy or biopreservation where the controlled and reproducible use of a thermal process can either preserve or destroy tissues with characteristic dimensions at the millimeter scale. Unfortunately, precise knowledge of the thermal properties that govern heat transfer within thin (mm scale and below) and anisotropic (i.e. multi-layered and directionally oriented) cardiovascular tissues is currently lacking in the literature. Fundamentally this is because the current standard techniques for measuring thermal properties of biological tissues involve mm-scale probes and cm-scale tissue samples. This project will address this limitation through adaptation of the 3 omega technique for these measurements. It will yield a number of important new intellectual contributions including: (1) A modified 3 omega test configuration which accommodates biological soft tissue for measurement with precise temperature and optical access; (2) A new set of property measurements in tissues with characteristic sizes from 1 mm to 10s of microns; (3) An assessment of the importance of anisotropy in cardiovascular tissue thermal properties (i.e. impact of layers and directionality in the tissue structure); and (4) A quantification of interfacial effects including contact resistance during thermal treatments in target and adjacent tissues (i.e. esophagus, lung and nerve impact of heart thermal treatments). In addition, although the initial focus will be on cardiovascular applications, this study will lay the groundwork for thermal property characterization necessary for other important preservation or therapy treatments in as yet uncharacterized biological tissues including fascia, neural, gastro-intestinal and other thin multi-layered tissues.This project will measure the thermal properties of biological tissue with small-scale dimensions. It will utilize a measurement method used to determine properties of thin inorganic materials with suitable modifications to be applied for biological tissue. The measured data from this research will greatly contribute to the formalization of a thermal property database for many types of biological tissue not currently known, and to the development of more reliable thermal prediction models. This project will influence the development of future enhancements to biomedical devices utilizing thermal energy for disease treatment, and it could help identify new strategies for more effective preservation of pharmaceutical and food products.

CBET 1236760 PI：Bischof组织中的热传输测量和建模在心血管生物医学中越来越重要，例如局部治疗或生物保存，其中热过程的受控和可重复使用可以保存或破坏具有毫米尺度特征尺寸的组织。不幸的是，在薄（毫米级及以下）和各向异性（即多层和定向）的心血管组织内的热传递的热性能的精确知识，目前缺乏的文献。从根本上说，这是因为目前用于测量生物组织的热特性的标准技术涉及毫米级探针和厘米级组织样品。 本项目将通过采用3 Ω技术进行这些测量来解决这一限制。它将产生一些重要的新的知识贡献，包括：（1）修改后的3 Ω测试配置，可适应生物软组织的测量与精确的温度和光学访问;（2）一套新的属性测量组织的特征尺寸从1毫米到10微米;（3）评估各向异性在心血管组织热特性中的重要性（即组织结构中的层和方向性的影响）;和（4）在目标和邻近组织中的热处理期间（即心脏热处理的食道、肺和神经影响），包括接触电阻的界面效应的量化。此外，虽然最初的重点是心血管应用，但本研究将为筋膜、神经、胃肠等薄的多层组织等尚未表征的生物组织的其他重要保存或治疗所需的热特性表征奠定基础。本项目将测量小尺度生物组织的热特性。它将利用一种测量方法，用于确定薄无机材料的特性，并进行适当的修改，以应用于生物组织。从这项研究中测得的数据将大大有助于目前未知的许多类型的生物组织的热特性数据库的形式化，并开发更可靠的热预测模型。该项目将影响未来利用热能治疗疾病的生物医学设备的改进，并有助于确定更有效地保存药品和食品的新策略。