NSF Engineering Research Center for Advanced Technologies for Preservation of Biological Systems (ATP-Bio)

NSF 生物系统保护先进技术工程研究中心 (ATP-Bio)

• 批准号: 1941543
• 负责人: John Bischof
• 金额: $ 2599.95万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1941543&HistoricalAwards=false
• 关键词: NSF; Engineering; Research; Center; Advanced

The ERC for Advanced Technologies for the Preservation of Biological Systems (ATP-Bio) aims to “stop biological time” and radically extend the ability to bank and transport cells, aquatic embryos, tissue, skin, whole organs, microphysiological systems (“organs-on-a-chip”), and even whole organisms through a team approach to build advanced biopreservation technologies. In order to build a more robust and diverse STEM workforce, especially in the growing number of fields needing biopreservation technologies, ATP-Bio also aims for equitable STEM education across all components of the Center. As such, ATP-Bio’s workforce development plan is purposefully designed to promote interest and engagement in STEM for all students. ATP-Bio will engage middle schoolers and high schoolers with biopreservation science and technology, fund numerous research internships in ATP-Bio labs for undergraduates, sponsor dozens of graduate students and postdoctoral researchers in ATP-Bio labs, and facilitate dozens of internships in the biopreservation industry. ATP-Bio will also include a focused effort on Ethics and Public Policy so that the Center’s technology will be legally and ethically translated to public benefit. Together with a large and active group of industrial partners, ATP-Bio aims to produce massive social benefit through “off-the-shelf” biopreservation technologies for cell therapies, tissue and organ transplantation, pharmacological research, aquaculture, biodiversity efforts, and many other fields.ATP-Bio will accomplish its goals by engineering technologies for biological systems before cooling, during cooling and stasis at subzero temperatures, and during rewarming to normal biological temperatures. At each stage, ATP-Bio convergent science teams will aim to eliminate or control ice formation, mitigate the toxicity of cryopreservation agents, and eliminate thermal and mechanical stress. The integration of Engineering and Workforce Development and Diversity and Culture of Inclusion across all components of ATP-Bio is aimed at creating a more diverse STEM workforce that understands team science, especially for the growing number of fields needing biopreservation technologies. ATP-Bio will leverage the long-term nature of an ERC to conduct research on developing positive STEM identity for all students and improving STEM pathways for K-12 and undergraduate STEM education, especially for women and minorities under-represented in academic and industrial STEM fields. ATP-Bio will also include focused research on Ethics and Public Policy so that the Center’s technology will be legally and ethically translated to public benefit.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物系统保存先进技术ERC（ATP-Bio）旨在“停止生物时间”，并通过团队方法从根本上扩展细胞、水生胚胎、组织、皮肤、整个器官、微生理系统（“芯片上的器官”）甚至整个生物体的储存和运输能力，以建立先进的生物保存技术。为了建立一个更强大和多样化的干劳动力，特别是在越来越多的需要生物保护技术的领域，ATP-Bio还旨在为中心的所有组成部分公平的干教育。因此，ATP-Bio的劳动力发展计划旨在促进所有学生对STEM的兴趣和参与。ATP-Bio将让中学生和高中生参与生物保护科学和技术，为本科生在ATP-Bio实验室的众多研究实习提供资金，赞助ATP-Bio实验室的数十名研究生和博士后研究人员，并促进生物保护行业的数十名实习。ATP-Bio还将重点关注道德和公共政策，以便该中心的技术在法律和道德上转化为公共利益。ATP-Bio与众多活跃的工业合作伙伴一起，旨在通过“现成”的生物保存技术为细胞治疗、组织和器官移植、药理学研究、水产养殖、生物多样性研究和许多其他领域创造巨大的社会效益。ATP-Bio将通过工程技术为生物系统在冷却前、冷却期间和在零度以下的温度下停滞，以及在复温至正常生物温度期间。在每个阶段，ATP-Bio融合科学团队的目标是消除或控制冰的形成，减轻低温保存剂的毒性，并消除热应力和机械应力。ATP-Bio的所有组成部分都整合了工程和劳动力发展以及多样性和包容性文化，旨在创造一个更加多样化的STEM劳动力，了解团队科学，特别是对于越来越多需要生物保护技术的领域。ATP-Bio将利用ERC的长期性质，为所有学生开发积极的STEM身份，并改善K-12和本科STEM教育的STEM途径，特别是针对在学术和工业STEM领域代表性不足的女性和少数民族。ATP-Bio还将包括对伦理和公共政策的重点研究，以便该中心的技术将在法律和道德上转化为公共利益。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

The effect of blood cells retained in rat livers during static cold storage on viability outcomes during normothermic machine perfusion.

• DOI: 10.1038/s41598-021-02417-6
• 发表时间: 2021-11-30
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Haque O;Pendexter CA;Wilks BT;Hafiz EOA;Markmann JF;Uygun K;Yeh H;Tessier SN
• 通讯作者: Tessier SN

The Use of Pectins As Part of a Cryoprotective Solution For Long-term Storage of Human Platelet Concentrates

使用果胶作为冷冻保护溶液的一部分来长期储存人浓缩血小板

• DOI: 10.54680/fr22610110312
• 发表时间: 2022
• 期刊: Cryoletters
• 影响因子: 1
• 作者: Sergushkina, M.I.;Khudyakov, A.N.;Zaitseva, O.O.;Polezhaeva, T.V.;Solomina, O.N.;Vetoshkin, K.A.;Butolina, M.A.
• 通讯作者: Butolina, M.A.

DETECTING PULMONARY EDEMA THROUGHOUT EX VIVO LUNG PERFUSION

通过离体肺灌注检测肺水肿

• DOI: 10.1115/dmd2023-4133
• 发表时间: 2023
• 期刊: American Society of Mechanical Engineers
• 作者: Nadybal, Ryan;Wang, Andrew;Iaizzo, Paul A.
• 通讯作者: Iaizzo, Paul A.

Slow-delivery and distributed exchange of cryoprotective agents with hydrogel beads.

• DOI: 10.1016/j.cryobiol.2021.09.006
• 发表时间: 2021-12
• 期刊: Cryobiology
• 影响因子: 2.7
• 作者: Sevenler D;Bean H;Toner M;Sandlin RD
• 通讯作者: Sandlin RD

Optimization of Ex Vivo Machine Perfusion and Transplantation of Vascularized Composite Allografts.

• DOI: 10.1016/j.jss.2021.09.005
• 发表时间: 2022-03
• 期刊: The Journal of surgical research
• 作者: Burlage LC;Lellouch AG;Taveau CB;Tratnig-Frankl P;Pendexter CA;Randolph MA;Porte RJ;Lantieri LA;Tessier SN;Cetrulo CL Jr;Uygun K
• 通讯作者: Uygun K