GOALI: Rapid Prototyping of Microscale Structures for Active Medical Devices and Characterization at FDA

1250724 Narayan糖尿病是美国发病率和死亡率的主要原因。此外，这种疾病对少数族裔群体和老年人的影响不成比例。尽管先前的基于微针的胰岛素递送和葡萄糖感测努力已经设想了微针-组织接触延长的时间段，但是迄今为止没有研究试图在生物、化学和机械性质方面优化微针设计，以在能够进行200次皮肤穿透事件的手表形状因子装置内延长使用。PI将与美国领先的血糖仪制造商Prodigy Diabetic Care合作，开发一个全面的研究，教育和推广计划，包括用于胰岛素输送和葡萄糖传感的微针的快速原型设计。拟议的合作研究计划的主要好处是PI和研究生研究员密集访问Prodigy Diabetic Care最先进的设备，包括用于制备葡萄糖氧化酶的设备，确定葡萄糖氧化酶的一致性，确定血糖水平，制备胰岛素贴片，测试电子产品和设计仪表容器。500平方英尺的空间在神童糖尿病护理将致力于拟议的目标的努力。该GOALI提案的研究目标是应用称为双光子聚合的快速原型制作方法和最近开发的称为氧化锆混合材料的一类材料，以创建具有适当化学，生物，机械和功能特性的中空微针，用于手表形状因子设备的扩展使用。

1250724NarayanDiabetes mellitus is a leading cause of morbidity and mortality in the United States. In addition, this medical condition disproportionately affects individuals from minority ethnic groups as well as older individuals. Although previous microneedle-based insulin delivery and glucose sensing efforts have envisioned microneedle-tissue contact for extended periods of time, no study to date has sought to optimize microneedle design in terms of biological, chemical, and mechanical properties for extended use within a wristwatch form factor device that is capable of 200 skin penetration events. The PI will partner with a leading US-based manufacturer of glucose meters, Prodigy Diabetic Care, to develop a comprehensive research, education, and outreach program that involves rapid prototyping of microneedles for use in insulin delivery as well as glucose sensing. The main benefit of the proposed collaborative research program is intensive access for the PI and the graduate researcher to the state-of-the-art equipment at Prodigy Diabetic Care, including equipment for preparing glucose oxidase, determining the consistency of glucose oxidase, determining blood glucose levels, preparing insulin patches, testing electronics, and designing meter containers. Five hundred square feet of space at Prodigy Diabetic Care will be devoted to the proposed GOALI effort. The research objective of this GOALI proposal is to apply a rapid prototyping method known as two photon polymerization and a recently-developed class of materials known as zirconium oxide hybrid materials to create hollow microneedles with appropriate chemical, biological, mechanical, and functional properties for extended use in a wristwatch form factor device.