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High resolution near-field thermoacoustic sensing and imaging

高分辨率近场热声传感和成像

基本信息

批准号：
214937490
负责人：
Professor Dr. Vasilis Ntziachristos
金额：
--
依托单位：
Lehrstuhl für Biologische Bildgebung
依托单位国家：
德国
项目类别：
Reinhart Koselleck Projects
财政年份：
2012
资助国家：
德国
起止时间：
2011-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/214937490?language=en
关键词：
resolution near field thermoacoustic sensing

项目摘要

This proposal considers building fundamental knowledge on previously undocumented near-field thermoacoustic (NFT) technology for the development of a new sensing modality that can advance our understanding on the mechanisms and uses of electromagnetic absorption at the sub-cellular, cellular and tissue levels. Near-field technology leads to mesoscopic (30-200 micron) and to ultra-high (<5-10 micron) imaging resolution, which can 1) directly measure electro-magnetic (EM) energy deposition and effects in cells and tissues, 2) resolve dielectric properties and effects within cells/cellular compartments and tissues and 3) study intrinsic high resolution tissue contrast or extrinsically administered (para-) magnetic and (semi-)conductive particles used as contrast agents. The proposal foresees the development of 1) hybrid NFT and fluorescence microscopy and 2) a tissue imaging NFT system coupled with conventional ultrasound imaging. It then considers the independent study of electro-acoustic and magneto-acoustic contrast mechanisms. Finally it researches three application areas, i.e. 1) the direct measurement of EM depositions at the cellular and sub-cellular level and the observation of possible biological effects, using fluorescent tags, 2) the generation of methods to experimentally measure EM energy deposition and dielectric properties in tissues in high resolution and 3) the development of a portable sensing and imaging modality for medical applications in particular in bed-side or point of care.

本提案考虑建立以前未记录的近场热声（NFT）技术的基础知识，以开发一种新的传感方式，可以促进我们对亚细胞，细胞和组织水平上电磁吸收的机制和使用的理解。近场技术导致介观（30-200微米）和超高（<5-10微米）成像分辨率，它可以1)直接测量电磁（EM）能量在细胞和组织中的沉积和影响，2)解析细胞/细胞室和组织内的介电特性和影响，3)研究固有的高分辨率组织造影剂或外部施用（准）磁性和（半）导电颗粒用作造影剂。该提案预测了1)混合NFT和荧光显微镜的发展，2)组织成像NFT系统与传统超声成像相结合。然后考虑了电声和磁声对比机制的独立研究。最后，它研究了三个应用领域，即1)在细胞和亚细胞水平上直接测量EM沉积和观察可能的生物效应，使用荧光标签，2)生成实验方法，以高分辨率测量组织中的EM能量沉积和介电特性，3)开发用于医疗应用的便携式传感和成像模式，特别是在床边或护理点。