CNH: The Coupled Human Health and Environmental Dynamics of Schistosomiasis
CNH:血吸虫病的人类健康与环境动态的耦合
基本信息
- 批准号:1414102
- 负责人:
- 金额:$ 149.99万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-08-01 至 2020-01-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Ecological damage caused by human activity can directly influence infectious diseases and human health, but public health campaigns rarely turn to ecological solutions to mitigate infectious disease risk, instead favoring traditional approaches, such as vaccine development or drug treatment. This research project will conduct an experimental investigation of a novel disease-control strategy that incorporates the reintroduction of native prawns to determine whether they might help reduce the prevalence of the snails that host the parasitic worms for that spread schistosomiasis, which is one of the most prevalent parasitic diseases in the world. The project will test the idea that reintroduction of the native prawns as predators will repair the aquatic food web that has been disrupted by dam construction and significantly reduce transmission of schistosomiasis by reducing the prevalence of the parasites. The project will investigate whether and how prawn restoration can be sustainable as well as add an important protein food source and market resource for the people living along the rivers. The project will provide new understanding regarding the complex interaction of human and natural forces to alter patterns of disease transmission. It will enhance knowledge across a range of fields, including trophic ecology, epidemiology, aquaculture, economics, and other social sciences as well as mathematical modeling. The project therefore will provide new insights regarding how biodiversity may be enhanced, how human health may improve, and how native prawn aquaculture may provide benefits to the rural market economy. The transmission of schistosomiasis by parasites from infected snails when people use open water systems for bathing, washing clothes and equipment, tending livestock, farming, or playing has led to the infection of about 220 million people, with an estimated 200,000 deaths per year from schistosomiasis around the world. More than 95 percent of the infections are occur in Africa, and this project will be based in the Senegal River ecosystem of western Africa, but the project will provide both basic and applied insights regarding the dynamics of coupled natural and human systems related to the transmission of diseases in rivers and other water bodies in other locales, including many in the U.S. The project also will provide special education and training opportunities for post-doctoral researchers as well as graduate and undergraduate students. This project is supported by the NSF Dynamics of Coupled Natural and Human Systems (CNH) Program.The project will be conducted by researchers constituting a team drawn from many different disciplines. They will conduct experiments where prawns will be enclosed at water-use sites and disease transmission will be compared with control sites to determine the effect of prawns on snail abundance and on human infection rates. Reintroduction of the prawns will be combined with drug treatments and will be analyzed with economic models, consideration of human behavior, and monitoring of snail and human infections. The information from these components of the project will be synthesized with mathematical models. This project will contribute to the technology of cultivation of the prawns as part of the ecosystem recovery and augmentation of natural snail predators, and prawn-stocking and harvest strategies will be modeled to seek the best approach to maximize public health while also offering a nutritional and market incentive to sustain prawn populations.
人类活动造成的生态破坏可以直接影响传染病和人类健康,但公共卫生运动很少转向生态解决方案来减轻传染病风险,而是倾向于传统方法,如疫苗开发或药物治疗。本研究项目将对一种新的疾病控制策略进行实验性调查,该策略包括重新引入本地对虾,以确定它们是否有助于减少寄生虫传播血吸虫病的蜗牛的流行,血吸虫病是世界上最流行的寄生虫病之一。 该项目将测试这样一种想法,即重新引入作为捕食者的本地对虾将修复因大坝建设而被破坏的水生食物网,并通过减少寄生虫的流行来显着减少血吸虫病的传播。 该项目将调查对虾恢复是否以及如何可持续,并为生活在沿着的人们增加重要的蛋白质食物来源和市场资源。 该项目将使人们对人类和自然力量改变疾病传播模式的复杂相互作用有新的认识。 它将提高一系列领域的知识,包括营养生态学,流行病学,水产养殖,经济学和其他社会科学以及数学建模。 因此,该项目将提供关于如何增强生物多样性,如何改善人类健康以及本地对虾水产养殖如何为农村市场经济带来好处的新见解。 当人们使用开放的水系统洗澡,洗衣服和设备,照顾牲畜,耕作或玩耍时,受感染的蜗牛传播血吸虫病,导致约2.2亿人感染,估计全世界每年有20万人死于血吸虫病。 超过95%的感染发生在非洲,该项目将以西非的塞内加尔河生态系统为基础,但该项目将提供有关与其他地区河流和其他水体中疾病传播有关的自然和人类系统耦合动态的基本和应用见解,该项目还将为博士后研究人员以及研究生和本科生提供特殊的教育和培训机会。 该项目由美国国家科学基金会自然和人类系统耦合动力学(CNH)计划支持。该项目将由来自多个不同学科的研究人员组成的团队进行。 他们将进行实验,在用水地点封闭对虾,并将疾病传播与对照地点进行比较,以确定对虾对蜗牛数量和人类感染率的影响。 对虾的重新引入将与药物治疗相结合,并将通过经济模型,考虑人类行为以及监测蜗牛和人类感染进行分析。 来自项目这些组成部分的信息将与数学模型相结合。 该项目将促进对虾养殖技术,作为生态系统恢复和增加天然蜗牛捕食者的一部分,对虾放养和收获战略将被模拟,以寻求最佳方法,最大限度地提高公众健康,同时提供营养和市场激励,以维持对虾种群。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Cost-effectiveness of combining drug and environmental treatments for environmentally transmitted diseases
- DOI:10.1098/rspb.2020.0966
- 发表时间:2020-08-26
- 期刊:
- 影响因子:4.7
- 作者:Castonguay, Francois M.;Sokolow, Susanne H.;Sanchirico, James N.
- 通讯作者:Sanchirico, James N.
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Armand Kuris其他文献
Armand Kuris的其他文献
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{{ truncateString('Armand Kuris', 18)}}的其他基金
DISSERTATION RESEARCH:Understanding effects on climate change on parasitism in small mammals
论文研究:了解气候变化对小型哺乳动物寄生的影响
- 批准号:
1601362 - 财政年份:2016
- 资助金额:
$ 149.99万 - 项目类别:
Standard Grant
Collaborative Research: Modeling Infectious Diseases: How Much Ecological Complexity Must We Address?
合作研究:传染病建模:我们必须解决多少生态复杂性?
- 批准号:
1115965 - 财政年份:2011
- 资助金额:
$ 149.99万 - 项目类别:
Standard Grant
Anthropogenic Effects on Host-Trematode Dynamics
人为对宿主吸虫动力学的影响
- 批准号:
0224565 - 财政年份:2002
- 资助金额:
$ 149.99万 - 项目类别:
Continuing Grant
The Role of Parasites in Marine Ecosystems
寄生虫在海洋生态系统中的作用
- 批准号:
8023692 - 财政年份:1980
- 资助金额:
$ 149.99万 - 项目类别:
Standard Grant
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