I-Corps: Soft Analytic Imaging

I-Corps：软分析成像

• 批准号: 1506791
• 负责人: Emmanuelle Marquis
• 金额: $ 5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506791&HistoricalAwards=false
• 关键词: Corps; Soft; Analytic; Imaging

The possibility of imaging water-based systems at high spatial and chemical resolution in a relatively short amount of time would provide unique and critical information for a large number of research focused entities and industries. The objective of this I-Corps project is to determine market need for a new approach enabling the 3D nanoscale imaging of liquids using atom probe tomography (APT), a technique traditionally used for hard materials (metals, semiconductors and oxides).The high pay-off of the proposed approach resides in the versatility of the method that will allow not only water-based systems to be studied, but will also be applicable to water/metal and hard/soft interfaces. This impacts a large number of research areas relevant to the development of biological materials (cells and virus chemistry and structures, doping), medical area (contamination of cells by heavy metals, nanoparticles), chemical processes (nanoparticle chemistry, surface chemistry, nanoscale synthesis for catalytic applications, drug synthesis), and energy materials (such as structural materials for power plants, battery materials, and organic electronic devices). The proposed technology combines the technique of atom probe tomography that provides three-dimensional atom by atom reconstruction of materials with vitrification methods traditionally used for the imaging of biological samples. The device will enable cryo-freezing and transfer into the atom probe tomography instrument opening the analytical imaging technique to novel applications. The proposed technology for water-based samples would expand the imaging possibility of atom probe tomography to new areas and thus has the potential to greatly expand the user base for this imaging technique.

在相对较短的时间内以高空间和化学分辨率进行水性系统成像的可能性将为大量的研究集中的实体和行业提供独特而关键的信息。该I-Corps项目的目的是确定对新方法的市场需求，从而实现了使用原子探针断层扫描（APT）对液体进行3D纳米级成像，这是一种用于硬材料的技术（金属，半导体和氧化物）。所提出的方法的高收益在该方法的高度范围内也不得允许水基于水的速度/既可以使用水中的水平/都可以进行水。这影响了与生物材料开发（细胞和病毒化学和结构，兴奋剂），医疗区域（通过重金属对细胞的污染，纳米颗粒），化学过程（纳米颗粒化学，表面化学，纳米表面化学，纳米级化学，纳米级化合物，催化剂应用，电源材料）和结构材料（例如电动材料）的相关研究区域（纳米粒子化学，纳米表面化学，纳米表面化学，纳米化学材料和结构材料，诸如电动材料），与生物材料合成（纳米化学），这会影响大量研究领域（纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学，纳米粒子化学）。提出的技术结合了原子探针断层扫描的技术，该技术通过原子重建材料通过传统上用于生物样品成像的玻璃化方法来提供三维原子。该设备将使冷冻冻结并转移到原子探针断层扫描仪器中，以开放分析成像技术到新的应用。提议的水基样品技术将扩大原子探针断层扫描的成像可能性，因此有可能大大扩展此成像技术的用户群。