I-Corps: Soft Analytic Imaging

I-Corps：软分析成像

• 批准号: 1506791
• 负责人: Emmanuelle Marquis
• 金额: $ 5万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-12-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1506791&HistoricalAwards=false
• 关键词: Corps; Soft; Analytic; Imaging

The possibility of imaging water-based systems at high spatial and chemical resolution in a relatively short amount of time would provide unique and critical information for a large number of research focused entities and industries. The objective of this I-Corps project is to determine market need for a new approach enabling the 3D nanoscale imaging of liquids using atom probe tomography (APT), a technique traditionally used for hard materials (metals, semiconductors and oxides).The high pay-off of the proposed approach resides in the versatility of the method that will allow not only water-based systems to be studied, but will also be applicable to water/metal and hard/soft interfaces. This impacts a large number of research areas relevant to the development of biological materials (cells and virus chemistry and structures, doping), medical area (contamination of cells by heavy metals, nanoparticles), chemical processes (nanoparticle chemistry, surface chemistry, nanoscale synthesis for catalytic applications, drug synthesis), and energy materials (such as structural materials for power plants, battery materials, and organic electronic devices). The proposed technology combines the technique of atom probe tomography that provides three-dimensional atom by atom reconstruction of materials with vitrification methods traditionally used for the imaging of biological samples. The device will enable cryo-freezing and transfer into the atom probe tomography instrument opening the analytical imaging technique to novel applications. The proposed technology for water-based samples would expand the imaging possibility of atom probe tomography to new areas and thus has the potential to greatly expand the user base for this imaging technique.

在相对较短的时间内以较高的空间和化学分辨率成像水基系统的可能性将为大量注重研究的实体和行业提供独特和关键的信息。这个I-Corps项目的目标是确定市场对一种新方法的需求，该方法能够使用原子探针断层扫描(APT)对液体进行3D纳米级成像，这是一种传统上用于硬材料(金属、半导体和氧化物)的技术。拟议方法的高回报在于该方法的多功能性，它不仅允许研究基于水的系统，还将适用于水/金属和硬/软界面。这影响到与生物材料(细胞和病毒的化学和结构、掺杂)、医学领域(重金属、纳米颗粒对细胞的污染)、化学过程(纳米颗粒化学、表面化学、用于催化应用的纳米级合成、药物合成)和能源材料(如发电厂的结构材料、电池材料和有机电子设备)的发展相关的大量研究领域。这项拟议的技术结合了原子探针断层扫描技术和传统上用于生物样品成像的玻璃化方法。原子探针断层扫描技术提供了材料的逐个原子的三维重建。该装置将使冷冻成为可能，并转移到原子探针断层扫描仪器中，为新的应用打开分析成像技术的大门。提出的水基样品成像技术将原子探针层析成像的可能性扩展到新的领域，因此有可能极大地扩大这种成像技术的用户基础。