New Methods for Structural Biology in Solution

该项目旨在扩大核磁共振（NMR）光谱在药物研究中的应用范围，其中NMR光谱已经常规用于识别与蛋白质靶点结合的化合物。开发的技术旨在提供快速和广泛适用的工具，结合到他们的蛋白质靶化合物的三维结构测定，蛋白质-蛋白质相互作用位点的鉴定和蛋白质运动的表征。NMR光谱学的极限将被推到分析分子量显着增加的系统。该项目包括应用于药物靶点，如登革热病毒NS 2B/NS 3蛋白酶。

This project aims to expand the range of applications of nuclear magnetic resonance (NMR) spectroscopy in pharmaceutical research, where NMR spectroscopy is already used routinely for the identification of chemical compounds that bind to protein targets. The techniques developed aim at providing rapid and broadly applicable tools for 3D structure determinations of chemical compounds bound to their protein target, identification of protein-protein interaction sites and characterization of protein motions. The limits of NMR spectroscopy will be pushed to analyse systems of significantly increased molecular weights. The project includes applications to drug targets such as the dengue virus NS2B/NS3 protease.