Proteins in motion - new tools for biotechnology
Proteins in motion - new tools for biotechnology
批准号:
FL170100019
负责人:
Prof Gottfried Otting
金额:
$183.67万
依托单位国家:
澳大利亚
项目类别:
Australian Laureate Fellowships
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-09-21 至 2022-09-20
中文摘要
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英文摘要
This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know-how to Australia and allow the interrogation of 3D structure and dynamics in selected protein regions. The expected outcomes of the project will have immediate benefits for the rational engineering of biocatalysts and in the design of lead compounds in drug development.
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Enhanced high-field nuclear magnetic resonance spectroscopy
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批准号:LE220100009
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$0.0万
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财政年份:2022
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负责人:Prof Gottfried Otting
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依托单位:
Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$11.92万
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财政年份:2018
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负责人:Prof Gottfried Otting
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依托单位:
Drug discovery and structural biology by NMR spectroscopy
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批准号:DP170100162
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项目类别:Discovery Projects
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资助金额:$36.31万
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财政年份:2017
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负责人:Prof Gottfried Otting
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依托单位:
New methods for structural biology and drug discovery by nuclear magnetic resonance spectroscopy
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批准号:DP140100304
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项目类别:Discovery Projects
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资助金额:$48.58万
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财政年份:2014
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负责人:Prof Gottfried Otting
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依托单位:
Multinuclear 700 MHz Nuclear Magnetic Resonance (NMR) spectrometer for advanced molecular analysis
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批准号:LE130100213
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$56.01万
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财政年份:2013
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负责人:Prof Gottfried Otting
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依托单位:
New methods for structure analysis of proteins and protein interactions
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批准号:DP110102737
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项目类别:Discovery Projects
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资助金额:$35.13万
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财政年份:2011
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负责人:Prof Gottfried Otting
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依托单位:
New fragment-based drug design technology by NMR spectroscopy
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批准号:DP0985549
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项目类别:Discovery Projects
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资助金额:$45.31万
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财政年份:2009
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负责人:Prof Gottfried Otting
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依托单位:
New Methods for Structural Biology in Solution
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批准号:DP0877540
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项目类别:Discovery Projects
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资助金额:$29.83万
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财政年份:2008
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负责人:Prof Gottfried Otting
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依托单位:
Fluorine-labelled proteins for NMR spectroscopy
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批准号:DP0664184
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项目类别:Discovery Projects
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资助金额:$26.86万
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财政年份:2006
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负责人:Prof Gottfried Otting
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依托单位:
New Methods for Structural Biology in Solution
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批准号:DP0342445
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项目类别:Discovery Projects
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资助金额:$86.91万
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财政年份:2003
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负责人:Prof Gottfried Otting
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依托单位:
New Methods for Structural Biology in Solution
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批准号:ARC : DP0342445
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项目类别:Discovery Projects
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资助金额:$122.0万
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财政年份:2003
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负责人:Prof Gottfried Otting
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依托单位:
New Methods for Structural Biology in Solution
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批准号:FF0241309
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项目类别:Federation Fellowships
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资助金额:$101.94万
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财政年份:2002
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负责人:Prof Gottfried Otting
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依托单位:
800 MHz NMR Spectrometer for Molecular Structure-Function Analyses
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批准号:LE0346876
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项目类别:Linkage Infrastructure, Equipment and Facilities
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资助金额:$105.62万
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财政年份:2002
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负责人:Prof Gottfried Otting
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依托单位:
国内基金
海外基金
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