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Proteins in motion - new tools for biotechnology

Proteins in motion - new tools for biotechnology
运动中的蛋白质——生物技术的新工具
批准号:
FL170100019
负责人:
Prof Gottfried Otting
金额:
$183.67万
依托单位国家:
澳大利亚
项目类别:
Australian Laureate Fellowships
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-09-21 至 2022-09-20

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中文摘要
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英文摘要
This project aims to assess the function of proteins by monitoring their motions using new nuclear magnetic resonance (NMR) spectroscopy techniques. As snapshots of 3D protein structures have been determined by crystallography, the new tools are designed to analyse functionally important motions in solution. A facility for ultrafast (> 100 kHz) magic angle spinning NMR spectroscopy of proteins in the semi-solid state will bring cutting-edge know-how to Australia and allow the interrogation of 3D structure and dynamics in selected protein regions. The expected outcomes of the project will have immediate benefits for the rational engineering of biocatalysts and in the design of lead compounds in drug development.
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Enhanced high-field nuclear magnetic resonance spectroscopy
  • 批准号:
    LE220100009
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $0.0万
  • 财政年份:
    2022
  • 负责人:
    Prof Gottfried Otting
  • 依托单位:
Ultrafast magic angle spinning solid-state nuclear magnetic resonance capability
  • 批准号:
    LE180100026
  • 项目类别:
    Linkage Infrastructure, Equipment and Facilities
  • 资助金额:
    $11.92万
  • 财政年份:
    2018
  • 负责人:
    Prof Gottfried Otting
  • 依托单位:
Drug discovery and structural biology by NMR spectroscopy
  • 批准号:
    DP170100162
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $36.31万
  • 财政年份:
    2017
  • 负责人:
    Prof Gottfried Otting
  • 依托单位:
New methods for structural biology and drug discovery by nuclear magnetic resonance spectroscopy
  • 批准号:
    DP140100304
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $48.58万
  • 财政年份:
    2014
  • 负责人:
    Prof Gottfried Otting
  • 依托单位:
国内基金
海外基金
穴位-靶器官效应的交互调节与穴位配伍的生物学机制
动态整体面孔认知加工的认知机制的研究
  • 批准号:
    31070908
  • 项目类别:
    面上项目
  • 资助金额:
    31.0万元
  • 批准年份:
    2010
  • 负责人:
    葛列众
  • 依托单位:
基于计算和存储感知的运动估计算法与结构研究
  • 批准号:
    60803013
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    18.0万元
  • 批准年份:
    2008
  • 负责人:
    邓磊
  • 依托单位:
前庭内侧核内GABA参与晕动症时心血管功能失调的作用机制