Study of Synthetic/Living Feedback Systems Enabled by Innovation in Shape-Memory Polymers

非技术生物材料通常用于研究细胞和组织。一些生物材料被设计具有特定的特性，例如刚度或表面形状，以研究细胞和组织如何对这些特性做出反应。这第一类生物材料正在提高对细胞和组织在健康或疾病中如何工作以及细胞和组织在与生物材料接触时如何反应的理解，例如用于医疗器械的生物材料。其他生物材料被设计成“智能”的，这意味着它们可以在暴露于水、光或其他触发物时发生特性变化，如刚度或表面形状。第二类生物材料为研究或治疗中控制细胞和组织提供了新的工具。该项目将创建和研究联合收割机前两种特性的新的第三类生物材料。这些新的生物材料不仅具有细胞和组织响应的特定特性，而且还具有“智能”，能够对细胞和组织的存在做出响应。通过研究材料与细胞和组织的来回相互作用，将对细胞和组织如何工作以及材料如何用于控制它们产生新的理解。社会将进一步受益于一个年度研讨会，将培训中央高中教师“制造智能材料。“刺激响应生物材料已被开发用于检测或控制生物系统，但这些生物材料的潜力可能在很大程度上尚未开发。潜在的变革机会是将刺激响应生物材料与生物系统相结合，以创建混合反馈系统，该系统可以为合成/生命材料系统界面处的现象提供新的见解。拟议研究的目标是创造新的刺激响应形状记忆聚合物，并在创新的合成/生活反馈系统中研究它们。将追求三个目标。首先，调整细胞相容的形状记忆聚合物用于光热刺激。第二，开发和理解酶响应形状记忆聚合物。第三，研究合成/生活反馈系统，这两个系统是成像启用和半自主和系统的材料启用和完全自主。这项工作的目的是在两个方面进行变革：它将导致新的材料设计;它将使新的材料现象的发现成为可能。社会将受益于个人的发展，并通过新的知识，有望推动先进的生物医学领域。此外，每年为期2天的研讨会将培训中央纽约STEM教师“制造智能材料。“技术刺激响应生物材料已被开发用于检测或控制生物系统，但这些生物材料的潜力可能在很大程度上尚未开发。潜在的变革机会是将刺激响应生物材料与生物系统相结合，以创建混合反馈系统，该系统可以为合成/生命材料系统界面处的现象提供新的见解。拟议研究的目标是创造新的刺激响应形状记忆聚合物，并在创新的合成/生活反馈系统中研究它们。将追求三个目标。首先，调整细胞相容的形状记忆聚合物用于光热刺激。第二，开发和理解酶响应形状记忆聚合物。第三，研究合成/生活反馈系统，这两个系统是成像启用和半自主和系统的材料启用和完全自主。这项工作的目的是在两个方面进行变革：它将导致新的材料设计;它将使新的材料现象的发现成为可能。社会将受益于个人的发展，并通过新的知识，有望推动生物医学领域的进步。此外，每年为期2天的研讨会将培训中央纽约STEM教师“制造智能材料。"

Non-TechnicalBiomaterials are often used to study cells and tissues. Some biomaterials are designed with specific properties, such as stiffness or surface shape, to study how cells and tissues respond to those properties. This first category of biomaterials is improving understanding of how cells and tissues work in health or disease and how cells and tissue respond when in contact with biomaterials, such as those used in medical devices. Other biomaterials are designed to be "smart", meaning that they can undergo changes in properties such as stiffness or surface shape in response to exposure to water, light, or other triggers. This second category of bio-materials is providing new tools for controlling cells and tissues in research or therapies. This project will create and study a new third category of biomaterials that combine the properties of the first two. These new biomaterials will not only have specific properties to which cells and tissues respond but will also be "smart" and capable of responding to the presence of the cells and tissues. By studying the back-and-forth interaction, with the material responding to the cells and tissues and vice versa, new understanding will be developed regarding how cells and tissues work and how materials can be used to control them. Society will further benefit from a yearly workshop that will train central high school teachers on "Making Smart Materials."Stimuli responsive biomaterials have been developed to assay or control biological systems, but the potential of these biomaterials may be largely untapped. The potentially transformative opportunity is that of integrating stimuli responsive biomaterials with biological systems to create hybrid feedback systems that can provide new insight into phenomena at the interface of synthetic/living material systems. The goal of the proposed research is to create new stimuli responsive shape-memory polymers and study them in innovative synthetic/living feedback systems. Three objectives will be pursued. First, to tune cytocompatible shape-memory polymers for photo-thermal stimulation. Second, to develop and understand enzyme-responsive shape-memory polymers. Third, to study synthetic/living feedback systems, both systems that are imaging-enabled and semiautonomous and systems that are material-enabled and fully autonomous. This work is designed to be transformative in two ways: it will lead to novel material designs; and it will enable discovery of new material phenomena. Society will benefit from both the development of the individuals involved and through new knowledge that promises to drive advanced in biomedical fields. In addition, a yearly 2-day workshop will train central New York STEM teachers on "Making Smart Materials."TechnicalStimuli responsive biomaterials have been developed to assay or control biological systems, but the potential of these biomaterials may be largely untapped. The potentially transformative opportunity is that of integrating stimuli responsive biomaterials with biological systems to create hybrid feedback systems that can provide new insight into phenomena at the interface of synthetic/living material systems. The goal of the proposed research is to create new stimuli responsive shape-memory polymers and study them in innovative synthetic/living feedback systems. Three objectives will be pursued. First, to tune cytocompatible shape-memory polymers for photo-thermal stimulation. Second, to develop and understand enzyme-responsive shape-memory polymers. Third, to study synthetic/living feedback systems, both systems that are imaging-enabled and semiautonomous and systems that are material-enabled and fully autonomous. This work is designed to be transformative in two ways: it will lead to novel material designs; and it will enable discovery of new material phenomena. Society will benefit from both the development of the individuals involved and through new knowledge that promises to drive advances in biomedical fields. In addition, a yearly 2-day workshop will train central New York STEM teachers on "Making Smart Materials."