Cellular response to pro-oxidative myoglobin

细胞对促氧化肌红蛋白的反应

• 批准号: DP0878559
• 负责人: Prof Paul Witting
• 金额: $ 29.15万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-02-18 至 2010-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0878559
• 关键词: Cellular; response; pro; oxidative; myoglobin

The heart is vulnerable to oxidative damage as specialised muscle cells termed myocytes are unable to regenerate. Oxidative damage to myocytes decreases cell viability and in turn heart muscle function. Pro-oxidative forms of the protein myoglobin are present in the heart and may play a role in damaging myocytes. This study will determine whether a series of novel synthetic antioxidants inhibit myoglobin-mediated damage to heart muscle and preserve function. This may lead to new therapies to combat cardiovascular disease and enable ageing Australians to maintain productive and independent lifestyles.

心脏易受氧化损伤，因为称为肌细胞的专门肌肉细胞无法再生。心肌细胞的氧化损伤降低细胞活力，进而降低心肌功能。促氧化形式的蛋白质肌红蛋白存在于心脏中，并可能在损伤肌细胞中发挥作用。这项研究将确定一系列新的合成抗氧化剂是否能抑制肌红蛋白介导的心肌损伤并保护功能。这可能会导致新的治疗方法来对抗心血管疾病，并使老年澳大利亚人能够保持富有成效和独立的生活方式。