Mechanically stable anti-adhesive polymer surfaces by biomimetic structuring

通过仿生结构实现机械稳定的抗粘聚合物表面

• 批准号: 228717992
• 负责人: Professor Dr.-Ing. Andrés Fabián Lasagni
• 金额: --
• 依托单位: Institut für Naturstofftechnik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/228717992?language=en
• 关键词: Mechanically; stable; anti; adhesive; polymer

Avoiding bacterial settlement is important for materials applied in biomedical technology. Mimicking naturally occurring surfaces offers promising solutions to meet this requirement. Starting from the non-wetting, anti-adhesive and mechanically stable skin of collembola (springtails) we propose to apply nanoreplication and laser interference lithography to create polymer surfaces with similar characteristics. Nanoreplicas that contain the hierarchical topography of the cuticle shall be applied to investigate the impact of the nanoscale structural elements and the chemical surface composition on their anti-adhesive behavior. Laser interference lithography shall be used to recapitulate arrays of individual structural elements of the skin in varying dimensions and shapes. The characteristics of the structured polymer surfaces shall be quantitatively analyzed with respect to wetting, protein adsorption and settlement of different types of bacteria. Detailed investigations of the initial bacterial adhesion (using, e.g., adhesion force measurements, combined with the detection of molecular components of the bacterial matrix) and colonization on the structured materials shall be performed to draw general conclusions on factors that influence bacterial adhesion at artificial surfaces. Based on that, principle solutions shall be developed to scale up effective surface structures for materials applied in medical devices.

对于生物医学技术中应用的材料来说，避免细菌沉降是很重要的。模仿自然产生的表面为满足这一要求提供了有希望的解决方案。从弹尾目(弹尾目)的非湿润、抗粘连和机械稳定的皮肤开始，我们建议应用纳米复制和激光干涉光刻来创建具有相似特征的聚合物表面。应使用包含角质层分层形貌的纳米复制体来研究纳米级结构元素和化学表面成分对其抗粘连行为的影响。应使用激光干涉光刻来概括不同尺寸和形状的皮肤单个结构元素的阵列。应根据不同类型细菌的润湿、蛋白质吸附和沉降对结构化聚合物表面的特性进行定量分析。应对结构材料上的初始细菌黏附(例如，使用粘附力测量，结合细菌基质的分子成分检测)和定植进行详细调查，以得出关于影响人工表面细菌黏附的因素的一般性结论。在此基础上，提出了扩大医疗器械材料有效表面结构的原则性解决方案。

项目成果

Evaluation of Surface Microtopography Engineered by Direct Laser Interference for Bacterial Anti-Biofouling.

• DOI: 10.1002/mabi.201500107
• 发表时间: 2015-04
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: Jaione Valle;Saioa Burgui;D. Langheinrich;C. Gil;C. Solano;Alejandro Toledo-Arana;R. Helbig;A. Lasagni;Í. Lasa

UV Direct Laser Interference Patterning of polyurethane substrates as tool for tuning its surface wettability

• DOI: 10.1016/j.apsusc.2015.11.119
• 发表时间: 2016-06-30
• 期刊: APPLIED SURFACE SCIENCE
• 影响因子: 6.7
• 作者: Estevam-Alves, Regina;Guenther, Denise;Lasagni, Andres F.
• 通讯作者: Lasagni, Andres F.