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EAGER: A Framework for Learning Graph Algorithms with Applications to Social and Gene Networks

EAGER: A Framework for Learning Graph Algorithms with Applications to Social and Gene Networks
EAGER:学习图算法及其在社交和基因网络中的应用的框架
批准号:
1841351
负责人:
Srinivas Aluru
金额:
$30.0万
依托单位国家:
美国
项目类别:
Standard Grant
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-01 至 2021-08-31

项目摘要

项目成果

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中文摘要
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英文摘要
Many real world applications, such as discovering gene interaction networks, detecting fraud in financial networks and personalizing recommendations in social networks, involve NP-hard graph problems. Typically, approximation or heuristic algorithms designed for these problems rely heavily on manually specified structural information of graphs. Furthermore, previous graph algorithms seldom systematically exploit a common trait of industrial graph problems: instances of the same type of problem need to be solved repeatedly on a regular basis, and algorithms which are effective on average are more preferable than those with only a worst case guarantee. This project explores a novel deep learning framework for automating the design of algorithms for challenging graph problems. The framework delegates difficult choices during the design to deep learning models, and uses a distribution of problem instances to train effective graph algorithms. The project presents a paradigm shift in graph algorithm design, and results in a software package to disseminate the research. The project also involves a broader swath of students including undergraduates and underrepresented minorities through multiple existing summer research internship programs that target students nationwide.More specifically, the framework casts a graph algorithm as a composition of many small learnable operators either because it works on graph inputs, produces structured outputs, or the computation graph of the algorithm itself contains structures such as branches and recursions. Instead of specifying each operator manually as in traditional algorithm design, the framework parameterizes these operators using nonlinear embeddings, and learns them jointly from graph input and output pairs using supervised learning or reinforcement learning. Though demonstrated in specific gene and social networks, the framework is generic and broadly applicable to a large class of graph analysis problems appearing in a diverse range of real world applications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
期刊论文(4)
专著(0)
科研奖励(0)
会议论文
DOI: --
发表时间: 2019-06
期刊: ArXiv
影响因子: --
作者: [H. Shrivastava;Xinshi Chen;Binghong Chen;Guanghui Lan;Srinvas Aluru;Le Song]
通讯作者: H. Shrivastava;Xinshi Chen;Binghong Chen;Guanghui Lan;Srinvas Aluru;Le Song
GRNUlar: A Deep Learning Framework for Recovering Single-Cell Gene Regulatory Networks
GRNUlar:用于恢复单细胞基因调控网络的深度学习框架
DOI: 10.1089/cmb.2021.0437
发表时间: 2022
期刊: Journal of Computational Biology
影响因子: 1.7
作者: [Shrivastava, Harsh, Zhang, Xiuwei, Song, Le, Aluru, Srinivas]
通讯作者: Aluru, Srinivas
Molecule optimization by explainable evolution
通过可解释的进化进行分子优化
DOI: --
发表时间: 2021
期刊: International Conference on Learning Representation (ICLR
影响因子: --
作者: [Chen, Binghong, Wang, Tianzhe, Li, Chengtao, Dai, Hanjun, Song, Le]
通讯作者: Song, Le
A scalable integrated multi-modal single cell analysis framework for gene regulatory and cell-cell interaction networks
  • 批准号:
    2233887
  • 项目类别:
    Continuing Grant
  • 资助金额:
    $54.58万
  • 财政年份:
    2023
  • 负责人:
    Srinivas Aluru
  • 依托单位:
BD Hubs: Collaborative Proposal: SOUTH:The South Big Data Innovation Hub
  • 批准号:
    1916589
  • 项目类别:
    Cooperative Agreement
  • 资助金额:
    $203.16万
  • 财政年份:
    2019
  • 负责人:
    Srinivas Aluru
  • 依托单位:
AF: Small: Algorithmic Techniques for High-throughput Analysis of Long Reads
  • 批准号:
    1816027
  • 项目类别:
    Standard Grant
  • 资助金额:
    $42.5万
  • 财政年份:
    2018
  • 负责人:
    Srinivas Aluru
  • 依托单位:
MRI: Acquisition of an HPC System for Data-Driven Discovery in Computational Astrophysics, Biology, Chemistry, and Materials Science
  • 批准号:
    1828187
  • 项目类别:
    Standard Grant
  • 资助金额:
    $369.93万
  • 财政年份:
    2018
  • 负责人:
    Srinivas Aluru
  • 依托单位:
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