Nanophotonic Strategies for Making Molecular Movies of Catalysis

制作催化分子电影的纳米光子策略

• 批准号: 1856518
• 负责人: Randall Goldsmith
• 金额: $ 46.47万
• 依托单位: University of Wisconsin-Madison
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1856518&HistoricalAwards=false
• 关键词: Nanophotonic; Strategies; Making; Molecular; Movies

In this study, supported by the Chemical Structure Dynamics and Mechanism (CSDM-A), Chemical Catalysis (CAT) and Chemical Measurement and Imaging (CMI) Program of the Chemistry Division, Professor Randall Goldsmith and his research team at the University of Wisconsin Madison seek to better understand how chemical catalysts perform their important functions. Catalysts allow difficult chemical reactions to be proceed, but how they do this may involve many individual steps that are difficult to follow. Professor Goldsmith is using a new approach that combines optical microscopy, the light-emitting behaviors of certain molecules (in this case, a property called "fluorescence"), and nanotechnology to to allow observation of single catalyst molecules. The Goldsmith team is essentially developing "molecular movies" of an individual operational catalysts. This research project is not only providing new insights into catalytic chemical reactions, but also developing a laboratory technique that may be useful in many other chemistry, biology and materials science investigations. The students involved in this research are gaining a wide range of skills, from chemical synthesis, optical microscopy, and nano-fabrication. In particular, the project focuses on palladium cross-coupling reactions, which are widely employed in the pharmaceutical industry. A critical element is the use of nanophotonic devices that sculpt light to make it substantially smaller than the diffraction-limit, allowing observation of single-molecule dynamics at chemically relevant concentrations. Individual catalyst molecules are immobilized in these devices and studied via single-molecule fluorescence microscopy. A major readout is the time-varying rate constant of a single catalyst molecule and the timescale of transient intermediates. The broader impacts of this work include the societal benefits of a mechanistic tool that can inform the design of the next generation of catalyst molecules, the training of students in interdisciplinary chemical sciences, and the development of single-molecule visualization demos that can be deployed in schools to broaden participation of STEM minorities.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这项研究中，由化学系的化学结构动力学和机制（CSDM-A），化学催化（CAT）和化学测量和成像（CMI）计划的支持下，Randall金匠教授和他在威斯康星州麦迪逊大学的研究团队寻求更好地了解化学催化剂如何发挥其重要功能。 催化剂使困难的化学反应得以进行，但它们如何做到这一点可能涉及许多难以遵循的单独步骤。 金匠教授正在使用一种新的方法，结合光学显微镜，某些分子的发光行为（在这种情况下，称为“荧光”的属性）和纳米技术，以允许观察单个催化剂分子。 金匠团队实际上是在开发一个单独的操作催化剂的“分子电影”。该研究项目不仅为催化化学反应提供了新的见解，而且还开发了一种可能在许多其他化学，生物学和材料科学研究中有用的实验室技术。 参与这项研究的学生正在获得广泛的技能，从化学合成，光学显微镜和纳米制造。特别是，该项目侧重于钯交叉偶联反应，这是广泛应用于制药行业。一个关键的元素是使用纳米光子设备，雕刻光，使其大大小于衍射极限，允许在化学相关浓度下观察单分子动力学。 单个催化剂分子固定在这些装置中，并通过单分子荧光显微镜进行研究。 一个主要的读数是一个单一的催化剂分子的时变速率常数和瞬态中间体的时间尺度。 这项工作的更广泛影响包括机械工具的社会效益，可以为下一代催化剂分子的设计提供信息，跨学科化学科学的学生培训，和发展的单一-分子可视化演示，可以部署在学校，以扩大STEM少数民族的参与。这个奖项反映了NSF的法定使命，并已被认为是值得通过使用评估支持基金会的学术价值和更广泛的影响审查标准。