MRI: Acquisition of Flow Cytometer Instrument at University of Michigan-Dearborn

流式细胞术/细胞分选是一种高通量技术，用于在大细胞群的基础上对每个细胞进行高水平的定性和定量分析。密歇根大学迪尔伯恩分校收购新的流式细胞仪设备将促进对肿瘤动力学、青光眼、胰岛微流体、抗癌治疗以及脑损伤和感染的研究。作为该项目的一部分，还包括一项在邻近大学之间广泛共享该仪器的战略。新仪器将有助于开发生物工程和自然科学的多学科本科生和研究生课程。此外，该仪器将提供机会开发有趣的科学和工程推广活动，向来自大底特律地区的高中生和教师介绍生物工程。本科生暑期研究项目，如本科生研究体验项目，将围绕大多数本科生可以轻松学习的流式细胞仪技术建立。收购流式细胞仪将大大提高密歇根大学迪尔伯恩分校生物工程研究的质量和范围。该大学的生物工程研究横跨多个领域，包括蛋白质聚集、工程肿瘤模型、细胞功能的生物物理表征、眼睛中的机械生物学途径、跨大脑的运输机制、纳米工程和胰岛微流体。流式细胞仪将通过提供有关颗粒/细胞悬浮液的物理和化学特征、细胞种群、细胞生物标记物的表达、蛋白质聚集和纳米颗粒毒性效应的信息来加强这些研究计划。流式细胞仪将为包括六名初级教师在内的用户团队提供建立新研究项目和扩大与其他机构研究人员合作所需的尖端工具。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

Flow cytometry/cell sorting is a high-throughput technique for doing high level qualitative and quantitative analysis on a per cell basis for large cell populations. The acquisition of new flow cytometry equipment at the University of Michigan-Dearborn will facilitate research on tumor dynamics, glaucoma, pancreatic islets microfluidics, therapeutics to combat cancer, and brain injury and infection. A strategy for wide sharing of the instrument among neighboring universities is included as part of this project. The new instrument will help in developing the multidisciplinary undergraduate and graduate curriculum in bioengineering and the natural sciences. Furthermore, the instrument will provide opportunities to develop interesting science and engineering outreach activities that introduce bioengineering to high school students and teachers from the greater Detroit area. Undergraduate summer research programs, such as the Research Experiences for Undergraduates program, will be built around the techniques of flow cytometry, which most undergraduate students can readily learn. The acquisition of a flow cytometer will substantially improve the quality and scope of bioengineering research at The University of Michigan-Dearborn. Bioengineering research at the university spans diverse areas, including protein aggregation, engineering tumor models, biophysical characterization of cellular functions, mechanobiological pathways in the eye, transport mechanisms across the brain, nanoengineering, and islet microfluidics. The flow cytometer will enhance these research programs by furnishing information on the physical and chemical characteristics of particles/cell suspensions, cell populations, expression of cellular biomarkers, protein aggregation, and nanoparticle toxicity effects. The flow cytometer will provide the team of users, which includes six junior faculty, with a cutting-edge tool necessary to establish new research programs and to broaden collaborations with researchers at other institutions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.