MRI: Acquisition of Flow Cytometer Instrument at University of Michigan-Dearborn

MRI：在密歇根大学迪尔伯恩分校购买流式细胞仪

• 批准号: 1919560
• 负责人: Mathumai Kanapathipillai
• 金额: $ 19.84万
• 依托单位: Regents of the University of Michigan - Ann Arbor
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2022-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1919560&HistoricalAwards=false
• 关键词: MRI; Acquisition; Flow; Cytometer; Instrument

Flow cytometry/cell sorting is a high-throughput technique for doing high level qualitative and quantitative analysis on a per cell basis for large cell populations. The acquisition of new flow cytometry equipment at the University of Michigan-Dearborn will facilitate research on tumor dynamics, glaucoma, pancreatic islets microfluidics, therapeutics to combat cancer, and brain injury and infection. A strategy for wide sharing of the instrument among neighboring universities is included as part of this project. The new instrument will help in developing the multidisciplinary undergraduate and graduate curriculum in bioengineering and the natural sciences. Furthermore, the instrument will provide opportunities to develop interesting science and engineering outreach activities that introduce bioengineering to high school students and teachers from the greater Detroit area. Undergraduate summer research programs, such as the Research Experiences for Undergraduates program, will be built around the techniques of flow cytometry, which most undergraduate students can readily learn. The acquisition of a flow cytometer will substantially improve the quality and scope of bioengineering research at The University of Michigan-Dearborn. Bioengineering research at the university spans diverse areas, including protein aggregation, engineering tumor models, biophysical characterization of cellular functions, mechanobiological pathways in the eye, transport mechanisms across the brain, nanoengineering, and islet microfluidics. The flow cytometer will enhance these research programs by furnishing information on the physical and chemical characteristics of particles/cell suspensions, cell populations, expression of cellular biomarkers, protein aggregation, and nanoparticle toxicity effects. The flow cytometer will provide the team of users, which includes six junior faculty, with a cutting-edge tool necessary to establish new research programs and to broaden collaborations with researchers at other institutions.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

流式细胞术/细胞分选是一种高通量技术，用于在每个细胞的基础上对大细胞群进行高水平的定性和定量分析。 在迪尔伯恩大学购买新的流式细胞仪设备将促进对肿瘤动力学、青光眼、胰岛微流体、抗癌疗法以及脑损伤和感染的研究。 作为该项目的一部分，还包括一项在邻近大学之间广泛分享该仪器的战略。 新的工具将有助于制定生物工程和自然科学的多学科本科生和研究生课程。此外，该工具将提供机会，发展有趣的科学和工程推广活动，介绍生物工程的高中学生和教师从大底特律地区。 本科生暑期研究计划，如本科生研究经验计划，将围绕流式细胞术技术，这是大多数本科生可以很容易地学习。流式细胞仪的收购将大大提高生物工程研究的质量和范围在迪尔伯恩大学。 该大学的生物工程研究跨越不同的领域，包括蛋白质聚集，工程肿瘤模型，细胞功能的生物物理表征，眼睛中的机械生物学途径，大脑中的运输机制，纳米工程和胰岛微流体。流式细胞仪将通过提供有关颗粒/细胞悬浮液、细胞群、细胞生物标志物表达、蛋白质聚集和纳米颗粒毒性效应的物理和化学特征的信息来增强这些研究计划。流式细胞仪将为包括六名初级教员在内的用户团队提供建立新的研究项目和扩大与其他机构研究人员合作所需的尖端工具。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。