MRI: Acquisition of a rapid-throughput NMR spectrometer at the University of Virginia

MRI：在弗吉尼亚大学购买快速通量核磁共振波谱仪

• 批准号: 2215062
• 负责人: Walter Harman
• 金额: $ 31.47万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215062&HistoricalAwards=false
• 关键词: MRI; Acquisition; rapid; throughput; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Virginia is acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a probe with multinuclear capabilities to support the research of Professor W. Dean Harman and colleagues Robert J. Gilliard and Thomas B. Gunnoe. This instrument facilitates research in the areas of synthetic organic chemistry, organometallic chemistry, catalysis, and chemical biology. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The multinuclear allows study of a wide range of elements above and beyond the common hydrogen and carbon atoms. This instrument enhances the educational, research, and teaching efforts of a diverse group of students and investigators from fourteen research groups across five departments. The instrument also enhances the research experiences of undergraduates, including those from underrepresented groups, at regional institutions.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as small molecule therapeutics, synthetic methodologies, and molecular interactions with biological materials. This instrument enables research focusing on synthetic organic methods, chemical biology, transition metal complex characterization, main group chemistry, and in situ mechanistic studies. The research projects to be enabled by the 400 MHz NMR spectrometer could lead to impacts in fields such as renewable energy, catalysis, and medicinal chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具和化学研究工具计划共同支持。弗吉尼亚大学将获得400 MHz核磁共振（NMR）光谱仪，该光谱仪配备了具有多核能力的探针，以支持W. Dean Harman教授和同事Robert J. Gilliard和Thomas B. Gunnoe的研究。该仪器促进了合成有机化学，有机化学，催化和化学生物学领域的研究。通常，核磁共振（NMR）光谱是化学家可用于阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。多核研究允许研究广泛的元素以外的氢和碳原子。该工具增强了来自五个部门的14个研究小组的各种学生和研究人员的教育，研究和教学工作。该工具还可以在区域机构中增强本科生的研究经历，包括代表性不足的群体的研究经验。400 MHz NMR幽灵仪的奖励旨在增强各级研究和教育，尤其是在小分子治疗学领域，例如合成方法，以及与生物学材料的分子相互作用。该仪器使研究重点是合成有机方法，化学生物学，过渡金属复合物特征，主要组化学和原位机械研究。该研究项目将由400 MHz NMR光谱仪启用，可能会导致可再生能源，催化和药物化学等领域的影响。这项奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛影响的审查标准来通过评估来获得支持的。