MRI: Acquisition of a rapid-throughput NMR spectrometer at the University of Virginia

该奖项由主要研究仪器项目和化学研究仪器项目共同支持。弗吉尼亚大学正在获取一台配备了具有多核能力的探测器的400 MHz核磁共振(核磁共振)光谱仪，以支持W·迪恩·哈曼教授及其同事罗伯特·J·吉拉德和托马斯·B·冈诺的研究。该仪器促进了合成有机化学、有机金属化学、催化和化学生物学领域的研究。总的来说，核磁共振波谱是化学家用来阐明分子结构的最强大的工具之一。它被用来识别未知物质，表征分子中原子的特定排列，并研究分子在溶液或固体中相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱仪是必不可少的。多核使人们可以研究普通氢原子和碳原子以外的各种元素。这一工具加强了来自五个系的14个研究小组的不同学生和研究人员的教育、研究和教学努力。该仪器还加强了本科生的研究经验，包括那些来自代表不足的群体的本科生，在地区机构。授予400 MHz核磁共振波谱仪旨在加强所有级别的研究和教育，特别是在小分子疗法、合成方法学和生物材料分子相互作用等领域。该仪器使研究重点集中在合成有机方法、化学生物学、过渡金属络合物表征、主族化学和原位机理研究。400 MHz核磁共振光谱仪支持的研究项目可能会在可再生能源、催化和药物化学等领域产生影响。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Virginia is acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a probe with multinuclear capabilities to support the research of Professor W. Dean Harman and colleagues Robert J. Gilliard and Thomas B. Gunnoe. This instrument facilitates research in the areas of synthetic organic chemistry, organometallic chemistry, catalysis, and chemical biology. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The multinuclear allows study of a wide range of elements above and beyond the common hydrogen and carbon atoms. This instrument enhances the educational, research, and teaching efforts of a diverse group of students and investigators from fourteen research groups across five departments. The instrument also enhances the research experiences of undergraduates, including those from underrepresented groups, at regional institutions.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as small molecule therapeutics, synthetic methodologies, and molecular interactions with biological materials. This instrument enables research focusing on synthetic organic methods, chemical biology, transition metal complex characterization, main group chemistry, and in situ mechanistic studies. The research projects to be enabled by the 400 MHz NMR spectrometer could lead to impacts in fields such as renewable energy, catalysis, and medicinal chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.