MRI: Acquisition of a rapid-throughput NMR spectrometer at the University of Virginia

该奖项由主要研究仪器和化学研究仪器项目联合支持。弗吉尼亚大学正在购买一台400兆赫核磁共振（NMR）光谱仪，该光谱仪配备了具有多核能力的探针，以支持W. Dean Harman教授及其同事Robert J. Gilliard和Thomas B. Gunnoe的研究。该仪器促进了合成有机化学、有机金属化学、催化和化学生物学等领域的研究。总的来说，核磁共振（NMR）波谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，以及研究溶液或固体状态下分子之间相互作用的动力学。获得最先进的核磁共振光谱仪是必不可少的化学家谁正在进行前沿研究。多核可以研究除常见的氢原子和碳原子以外的各种元素。该仪器增强了来自五个系的14个研究小组的不同学生和研究人员的教育、研究和教学努力。该工具还加强了本科生的研究经验，包括来自代表性不足群体的本科生在区域机构的研究经验。400 MHz核磁共振光谱仪的授予旨在加强各级的研究和教育，特别是在小分子治疗、合成方法和与生物材料的分子相互作用等领域。该仪器能够集中研究合成有机方法，化学生物学，过渡金属配合物表征，主基团化学和原位机制研究。由400兆赫核磁共振光谱仪启动的研究项目可能会对可再生能源、催化和药物化学等领域产生影响。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Virginia is acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a probe with multinuclear capabilities to support the research of Professor W. Dean Harman and colleagues Robert J. Gilliard and Thomas B. Gunnoe. This instrument facilitates research in the areas of synthetic organic chemistry, organometallic chemistry, catalysis, and chemical biology. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The multinuclear allows study of a wide range of elements above and beyond the common hydrogen and carbon atoms. This instrument enhances the educational, research, and teaching efforts of a diverse group of students and investigators from fourteen research groups across five departments. The instrument also enhances the research experiences of undergraduates, including those from underrepresented groups, at regional institutions.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as small molecule therapeutics, synthetic methodologies, and molecular interactions with biological materials. This instrument enables research focusing on synthetic organic methods, chemical biology, transition metal complex characterization, main group chemistry, and in situ mechanistic studies. The research projects to be enabled by the 400 MHz NMR spectrometer could lead to impacts in fields such as renewable energy, catalysis, and medicinal chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.