MRI: Acquisition of a rapid-throughput NMR spectrometer at the University of Virginia

MRI：在弗吉尼亚大学购买快速通量核磁共振波谱仪

• 批准号: 2215062
• 负责人: Walter Harman
• 金额: $ 31.47万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2215062&HistoricalAwards=false
• 关键词: MRI; Acquisition; rapid; throughput; NMR

This award is jointly supported by the Major Research Instrumentation and the Chemistry Research Instrumentation Programs. The University of Virginia is acquiring a 400 MHz Nuclear Magnetic Resonance (NMR) spectrometer equipped with a probe with multinuclear capabilities to support the research of Professor W. Dean Harman and colleagues Robert J. Gilliard and Thomas B. Gunnoe. This instrument facilitates research in the areas of synthetic organic chemistry, organometallic chemistry, catalysis, and chemical biology. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The multinuclear allows study of a wide range of elements above and beyond the common hydrogen and carbon atoms. This instrument enhances the educational, research, and teaching efforts of a diverse group of students and investigators from fourteen research groups across five departments. The instrument also enhances the research experiences of undergraduates, including those from underrepresented groups, at regional institutions.The award of the 400 MHz NMR spectrometer is aimed at enhancing research and education at all levels, especially in areas such as small molecule therapeutics, synthetic methodologies, and molecular interactions with biological materials. This instrument enables research focusing on synthetic organic methods, chemical biology, transition metal complex characterization, main group chemistry, and in situ mechanistic studies. The research projects to be enabled by the 400 MHz NMR spectrometer could lead to impacts in fields such as renewable energy, catalysis, and medicinal chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划共同支持。弗吉尼亚大学正在购买一台400 MHz核磁共振（NMR）光谱仪，该光谱仪配备了一个具有多核能力的探针，以支持W。迪安·哈曼和他的同事罗伯特·J·吉利亚德和托马斯B。甘诺该仪器促进了合成有机化学，有机金属化学，催化和化学生物学领域的研究。一般来说，核磁共振（NMR）光谱是化学家用来阐明分子结构的最有力的工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于从事前沿研究的化学家来说，使用最先进的NMR光谱仪是必不可少的。多核允许研究常见氢和碳原子之外的广泛元素。该工具增强了来自五个部门的十四个研究小组的学生和研究人员的多样化群体的教育，研究和教学工作。400 MHz核磁共振波谱仪的授予旨在加强各级的研究和教育，特别是在小分子治疗、合成方法以及分子与生物材料的相互作用等领域。该仪器可用于有机合成方法、化学生物学、过渡金属络合物表征、主族化学和原位机理研究。400 MHz核磁共振波谱仪支持的研究项目可能会在可再生能源、催化和药物化学等领域产生影响。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。