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Materials World Network: Fundamentals of Peptide Materials - Experimental and Simulation Probes

材料世界网络：肽材料基础 - 实验和模拟探针

基本信息

批准号：
238994672
负责人：
Professor Dr. Markus Valtiner
金额：
--
依托单位：
Institut für Angewandte Physik
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2016-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/238994672?language=en
关键词：
Materials World Network Fundamentals Peptide

项目摘要

Peptides have emerged as an important class of biocompatible, environmentally friendly, sustainable material alternatives. On the one hand, they can be engineered to self-assemble into a broad array of nanostructures important as tissue scaffolds, biosensors, drug delivery agents, and sacrificial templates for inorganic materials. On the other, they offer unique ways to modify solid interfaces with surface protecting, hydrophobic, antibiotic, or adhesive capabilities. However, their rational engineering is limited by lack of a detailed understanding of the ways in which their many distinct molecular interactions - hydrogen bonding, electrostatic, and hydrophobic forces, for example - act in concert or competition to produce complex, cooperative, many-body collective behavior. This study combines state-of-the-art atomic force microscopy (AFM) hand-in-hand with advanced molecular simulation studies to obtain innovative fundamental insights into peptide-peptide interactions and, in particular, their ability to mediate interactions at solid/liquid interfaces. Using a uniquely flexible model peptide repeat scaffold, precisely controllable sequences and numbers of interacting peptides will be examined, whereby interactions and cooperativities can be tuned with exacting control. Detailed AFM measurements will be compared to molecular pictures developed by equilibrium, quantitative all-atom simulations that probe true underlying, equilibrium interaction landscapes. In particular, the balance between hydrophobic and charge interactions and the effect of cooperative, multi-peptide interactions will be studied in a systematic and hierarchical manner.

多肽已经成为一类重要的生物相容、环境友好、可持续发展的材料替代品。一方面，它们可以被设计成自组装成广泛的纳米结构，如组织支架、生物传感器、药物递送剂和无机材料的牺牲模板。另一方面，它们提供了独特的方法来修饰具有表面保护、疏水、抗菌或粘合能力的固体界面。然而，他们的理性工程受限于对他们许多不同的分子相互作用--例如氢键、静电和疏水作用力--协调或竞争产生复杂、合作、多体集体行为的方式的详细了解。这项研究将最先进的原子力显微镜(AFM)与先进的分子模拟研究相结合，以获得对肽-肽相互作用的创新基础见解，特别是它们在固/液界面调节相互作用的能力。使用一种独特的灵活的模型多肽重复支架，将检查相互作用的多肽的精确可控的序列和数量，从而可以通过严格的控制来调节相互作用和协作性。详细的AFM测量将与通过平衡、定量的全原子模拟开发的分子图像进行比较，这些模拟探索真实的潜在、平衡相互作用场景。特别是，疏水和电荷相互作用之间的平衡以及协作、多肽相互作用的影响将以系统和分级的方式进行研究。