CPS: Medium: Deep Integration of Thin Flexible Autonomous Microsystems for Vision Correction

CPS：中：用于视力矫正的薄型柔性自主微系统的深度集成

• 批准号: 1932602
• 负责人: Carlos Mastrangelo
• 金额: $ 120万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1932602&HistoricalAwards=false
• 关键词: CPS; Medium; Deep; Integration; Thin

The goal of this work is the realization of autonomous cyber-physical, microsystems for automated correction of blurred vision using flexible electronic contact lenses. The vision correction system integrates thin variable power lenses with object distance microsensors and computation and control software to continuously produce sharply-focused images in individuals suffering from presbyopia. Presbyopia, or loss of the eye's ability to change focus, is an inevitable and universal age-related condition that affects aging adults, causing blurred images and visual impairment. In 2018, two billion people worldwide were estimated to suffer from presbyopia. The proposed vision correction microsystem operates autonomously while collecting energy from its surrounding environment in order to provide continuous vision correction for an entire day. Realization of such microsystems advances our scientific knowledge of autonomous microsystem engineering for medical applications, ultimately improving the daily lives and well-being of billions of aging adults while reducing the cost of treatment.The implementation of autonomous microsystems for vision correction requires deep integration of ultrathin state-of-the-art inhomogeneous microtechnologies including variable power liquid-crystal lenses, paper-thin embedded microprocessors and communications circuits with tens of millions of transistors, paper-thin microsensors to detect light level, user orientation and focal distance, and thin photovoltaic cells with power management circuits, all integrated onto a single flexible package that conforms to the surface of the human eye. The system must be able to scavenge power and manage its operation completely autonomously, in the best possible way, in a resource-limited biological environment. Advancements in systems with these characteristics are widely applicable to many future cyber physical systems (CPS) for medical and health monitoring applications. This extremely ambitious project pushes the frontiers of inhomogeneous microtechnology integration to a level that has been repeatedly dreamed of, but never realized before, to produce a highly integrated CPS that can benefit billions of people.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项工作的目标是实现自主的计算机物理微系统，用于使用灵活的电子隐形眼镜自动矫正视力模糊。该视力矫正系统将薄变倍镜片与物距微型传感器以及计算和控制软件相结合，以连续产生患有老花眼的个体的清晰聚焦图像。老花眼，即眼睛失去改变焦点的能力，是一种不可避免的、普遍的与年龄相关的疾病，影响到年迈的成年人，导致图像模糊和视力障碍。2018年，全球估计有20亿人患有老花眼。拟议的视力矫正微系统自主运行，同时从周围环境中收集能量，以提供全天的持续视力矫正。这些微系统的实现提高了我们对用于医疗应用的自主微系统工程的科学知识，最终改善了数十亿老年人的日常生活和福祉，同时降低了治疗成本。用于视力矫正的自主微系统的实施需要深度集成最先进的非均匀超薄微技术，包括可变功率液晶透镜、具有数千万晶体管的纸薄嵌入式微处理器和通信电路、用于检测光线水平、用户方位和焦距的纸薄微传感器，以及具有电源管理电路的薄型光伏电池，所有这些都集成到一个符合人眼表面的柔性封装中。该系统必须能够在资源有限的生物环境中以尽可能好的方式完全自主地收集电力并管理其运行。具有这些特征的系统的进步被广泛应用于许多未来用于医疗和健康监测应用的网络物理系统(CP)。这一极其雄心勃勃的项目将非均质微技术集成的前沿推向一个人们反复梦想但从未实现的水平，以产生一个可造福数十亿人的高度集成的CPS。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Low-Profile Stacked Digitally Tunable LC Fresnel Lens for Smart Contact Lens System

用于智能隐形眼镜系统的薄型堆叠式数字可调 LC 菲涅尔透镜

• DOI: 10.1109/ipc53466.2022.9975492
• 发表时间: 2022
• 期刊: 2022 IEEE Photonics Conference (IPC
• 作者: Ghosh, Chayanjit;Banerjee, Aishwaryadev;Karkhanis, Mohit;Pourshaban, Erfan;Kim, Hanseup;Mastrangelo, Carlos H.;Deshpande, Adwait
• 通讯作者: Deshpande, Adwait

Adhesion Strength of PDMS to Polyimide Bonding with Thin-film Silicon Dioxide

PDMS与薄膜二氧化硅聚酰亚胺粘合的粘合强度

• DOI: 10.1109/fleps51544.2021.9469779
• 发表时间: 2021
• 期刊: IEEE FLEPS
• 作者: Deshpande, Adwait;Pourshaban, Erfan;Ghosh, Chayanjit;Banerjee, Aishwaryadev;Kim, Hanseup;Mastrangelo, Carlos
• 通讯作者: Mastrangelo, Carlos

Microfabricated Low-Profile High Tunable LC Fresnel Lens for Smart Contacts

用于智能触点的微加工薄型高可调 LC 菲涅尔透镜

• DOI: 10.1109/ipc53466.2022.9975691
• 发表时间: 2022
• 期刊: 2022 IEEE Photonics Conference (IPC
• 作者: Banerjee, Aishwaryadev;Ghosh, Chayanjit;Karkhanis, Mohit;Deshpande, Adwait;Pourshaban, Erfan;Kim, Hanseup;Mastrangelo, Carlos H.
• 通讯作者: Mastrangelo, Carlos H.

A Micro-Fabricated Aluminum-Air Moving Biofluid Battery For Medical Wearables

用于医疗可穿戴设备的微制造铝空气移动生物流体电池

• DOI: 10.1109/mems51670.2022.9699832
• 发表时间: 2022
• 期刊: 2022 IEEE 35th International Conference on Micro Electro Mechanical Systems Conference (MEMS
• 作者: Pourshaban, Erfan;Deshpande, Adwait;Karkhanis, Mohit U.;Banerjee, Aishwaryadev;Ghosh, Chayanjit;Kim, Hanseup;Mastrangelo, Carlos H.
• 通讯作者: Mastrangelo, Carlos H.

Artificial Iris on Smart Contact Lens using Twisted Nematic Cell for Photophobia Alleviation

智能隐形眼镜上的人工虹膜使用扭曲向列细胞缓解畏光

• DOI: 10.1109/ipc57732.2023.10360753
• 发表时间: 2023
• 期刊: IEEE Photonics Conference
• 作者: Ghosh, Chayanjit;Deshpande, Adwait;Karkhanis, Mohit U.;Banerjee, Aishwaryadev;Pourshaban, Erfan;Hasan, Md. Rabiul;Nikeghbal, Amirali;Dastgir, Md. Golam;Kim, Hanseup;Mastrangelo, Carlos H.
• 通讯作者: Mastrangelo, Carlos H.