Batch-Fabricated Nanochannel Devices for Direct Electrical Probing of Biomolecules

用于生物分子直接电探测的批量制造的纳米通道装置

• 批准号: 0824180
• 负责人: Carlos Mastrangelo
• 金额: $ 33万
• 依托单位: Case Western Reserve University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-08-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0824180&HistoricalAwards=false
• 关键词: Batch; Fabricated; Nanochannel; Devices; Direct

NSF Proposal 0824180PI: C. H. Mastrangelo and S. BhuniaAbstractThe objective of this research is the development of a technology for mass production of low-cost nanochannel devices with electrodes. The project includes modeling, fabrication, characterization and testing these devices. The approach is to define nanochannels lithographically with sidewall batch fabrication techniques. Each device consists of a nanometer-sized channel with inlet and outlet openings and two metallic nanoelectrodes embedded across the nanochannel walls. Intellectual Merits: Nanochannel devices for single molecule probing and analysis are presently fabricated with direct write techniques which are not viable for low cost fabrication. In this program we will develop methods for mass production of low-cost nanochannel devices with transverse electrodes on silicon substrates. These structures will be tested and characterized in terms of their physical properties and their ability to interrogate macromolecules. Fast and accurate semi-analytical models for estimation of device parameters such as channel conductance in the presence and absence of single biomolecule will be developed. Broader Impacts: Single molecule interrogation technology using nanochannel probes provides tremendous opportunities in biological, environmental and clinical applications. The project will provide research and training opportunity to two graduate students; up to four undergraduate students and up to two high school students from Hathaway Brown, a local all girls school with a distinctive student research program. Emphasis will be given on recruiting bright underrepresented students, including minorities and women engineers. The technology developed through this project will be shared with peer research groups from various institutions for additional testing and characterization of the devices.

NSF提案0824180PI：C. H. Mastrangelo和S. Bhunia摘要本研究的目的是开发一种低成本的带电极的纳米通道器件的大规模生产技术。该项目包括建模，制造，表征和测试这些设备。该方法是定义纳米通道光刻侧壁批量制造技术。每个装置由具有入口和出口开口的纳米尺寸的通道和嵌入纳米通道壁的两个金属纳米电极组成。智力优势：用于单分子探测和分析的纳米通道器件目前用直接写入技术制造，这对于低成本制造是不可行的。在这个项目中，我们将开发低成本纳米通道器件的大规模生产方法，该器件在硅衬底上具有横向电极。这些结构将在其物理性质和询问大分子的能力方面进行测试和表征。快速和准确的半分析模型，用于估计设备参数，如通道电导在存在和不存在单一的生物分子将被开发。更广泛的影响：使用纳米通道探针的单分子询问技术在生物、环境和临床应用中提供了巨大的机会。该项目将提供研究和培训机会，两名研究生，多达四名本科生和多达两名高中生从海瑟薇布朗，当地所有女子学校与一个独特的学生研究计划。重点将放在招收代表性不足的聪明学生，包括少数民族和女工程师。通过该项目开发的技术将与来自不同机构的同行研究小组共享，以进行设备的额外测试和表征。