EAGER: Implantable Particle-Based Wireless Neurorecording Probes for Minimally-Intrusive 3D Mapping of Brain Signals

EAGER：可植入的基于粒子的无线神经记录探针，用于微创脑信号 3D 绘图

• 批准号: 1550743
• 负责人: Carlos Mastrangelo
• 金额: $ 30万
• 依托单位: University of Utah
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2017-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1550743&HistoricalAwards=false
• 关键词: EAGER; Implantable; Particle; Based; Wireless

Proposal No:1550743: EAGER: Implantable Particle-Based Wireless Neurorecording Probes for Minimally-Intrusive 3D Mapping of Brain SignalsFor the last thirty years neurorecording probe technologies have been implemented using arrays of needle like electrodes. The presence of needles in neural tissue causes extensive damage and inflammation that lead to scar tissue formation and eventual probe failure. This work proposes the use of electrodes arrays placed on the surface of sub-mm, instrumented spherical particles. The small, shank free particles thus allow for the healing of surrounding tissue after insertion minimizing scar tissue formation and extending probe life. This new technology has broad applicability in the realization of instrumentation for fundamental brain function studies, brain to machine interfaces and neural prostheses.The proposed work is divided into four separate tasks: (1) the development of new microfabrication technologies for construction of hollow, spherical micro-capsules with peripheral electrodes, (2) the development of ultracompact folded CMOS neurorecording circuits, (3) the development of compact RF biotelemetry circuits and (4) the testing of effectiveness, tissue damage and longevity of particle-based probes on small animals.

提案编号：1550743：EAGER：植入式基于颗粒的无线神经记录探头，用于 在过去的三十年里，神经记录探针技术已经使用针状电极阵列来实现。 针在神经组织中的存在引起广泛的损伤和炎症，导致瘢痕组织形成和最终探针失效。这项工作提出了使用电极阵列放置在表面上的亚毫米，仪表球形颗粒。 因此，小的无柄颗粒允许在插入后愈合周围组织，从而最小化疤痕组织形成并延长探针寿命。这项新技术在实现基本脑功能研究、脑机接口和神经假体的仪器方面具有广泛的适用性。拟议的工作分为四个独立的任务：（1）开发新的微制造技术，用于构造具有外围电极的中空球形微胶囊，（2）开发超紧凑折叠CMOS神经记录电路，（3）开发紧凑的RF生物遥测电路和（4）在小动物上测试基于粒子的探针的有效性、组织损伤和寿命。