MRI: Acquisition of a Single-Crystal X-Ray Diffractometer

MRI：获取单晶 X 射线衍射仪

• 批准号: 2018501
• 负责人: Timothy Johnstone
• 金额: $ 32.42万
• 依托单位: University of California-Santa Cruz
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2018501&HistoricalAwards=false
• 关键词: MRI; Acquisition; Single; Crystal; Ray

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of California Santa Cruz is acquiring a single crystal X-ray diffractometer to support Professor Scott Oliver and colleagues: Pradip Mascharak, Scott Lokey, John MacMillan and Timothy Johnstone. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighbors. The studies described here impact many areas, including organic and inorganic chemistry, materials chemistry and biochemistry. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution as well other departments. The science enabled by this instrument has the potential to impact society at this Hispanic-Serving Institution (HSI) through the development of new materials to address environmental pollution and energy production, and new catalysts to improve the synthesis of commodity and industrial chemicals. In addition, the instrumentation provides direct research experience for students in programs like the Minority Access to Research Careers Program and ACCESS, an academic bridge program for community college students who want to pursue careers in research science. The university allows nearby 2-year community colleges and 4-year post-secondary institutions that are also HSIs to have access to this instrumentation free of charge.The award of the X-ray diffractometer is aimed at enhancing research and education at all levels. The science enabled by this instrument provides relevant societal benefits through the development of new materials to address environmental pollution and energy production, and new catalysts to improve the synthesis of commodity and industrial chemicals. The instrumentation is used for studying main-group bioinorganic chemistry and compounds that may have the potential for use in the delivery of medicines. In addition, the instrument acquisition benefits exploration of marine natural products with the potential to discover possible therapeutic targets and therapeutics. The diffractometer is also used to characterize high-pressure and variable-temperature mineral physics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器计划支持。加州圣克鲁斯大学正在购买一台单晶X射线衍射仪，以支持Scott奥利弗教授及其同事：Pradip Mascharak，Scott Lokey，John MacMillan和Timothy Johnstone。一般来说，X射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。这里描述的研究影响了许多领域，包括有机和无机化学，材料化学和生物化学。该仪器是该机构以及其他部门的化学和生物化学本科生的教学和研究及研究培训的组成部分。该仪器所支持的科学有可能通过开发新材料来解决环境污染和能源生产，以及开发新催化剂来改善商品和工业化学品的合成，从而影响这个西班牙服务机构（HSI）的社会。此外，仪器为学生提供直接的研究经验，如少数民族获得研究职业计划和访问，学术桥梁计划的社区学院学生谁想要追求职业生涯的研究科学。该大学允许附近的两年制社区学院和四年制大专院校也是HSIs免费使用这种仪器。X射线衍射仪的奖励旨在加强各级的研究和教育。该工具所支持的科学通过开发新材料来解决环境污染和能源生产，以及开发新催化剂来改善商品和工业化学品的合成，从而提供相关的社会效益。该仪器用于研究可能用于药物输送的主要生物无机化学和化合物。此外，该仪器的获得有利于海洋天然产品的勘探，有可能发现可能的治疗靶点和治疗方法。该衍射仪还用于表征高压和变温矿物物理学。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Models of the putative antimony( v )–diolate motifs in antileishmanial pentavalent antimonial drugs

抗地利什曼病五价锑药物中推定锑( v )-二醇基序的模型

• DOI: 10.1039/d3dt01623d
• 发表时间: 2023
• 期刊: Dalton Transactions
• 影响因子: 4
• 作者: Lindquist-Kleissler, Brent;Johnstone, Timothy C.
• 通讯作者: Johnstone, Timothy C.

Steric congestion in heavy pnictines alters oxidative halogenation pathways

• DOI: 10.1016/j.poly.2023.116730
• 发表时间: 2023-11-15
• 期刊: POLYHEDRON
• 影响因子: 2.6
• 作者: Wenger，John S.;Getahun，Addis;Johnstone，Timothy C.
• 通讯作者: Johnstone，Timothy C.

Biomimetic Total Synthesis and Investigation of the Non-Enzymatic Chemistry of Oxazinin A.

• DOI: 10.1002/anie.202208029
• 发表时间: 2022-09-19
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Aniebok, Victor;Shingare, Rahul D.;Wei-Lee, Hsiau;Johnstone, Timothy C.;MacMillan, John B.
• 通讯作者: MacMillan, John B.

H-Atom Assignment and Sb–O Bonding of [Mes 3 SbOH][O 3 SPh] Confirmed by Neutron Diffraction, Multipole Modeling, and Hirshfeld Atom Refinement

通过中子衍射、多极建模和赫什菲尔德原子细化证实 [Mes 3 SbOH][O 3 SPh] 的 H 原子分配和 Sb−O 键合

• DOI: 10.1021/acs.inorgchem.1c02229
• 发表时间: 2021
• 期刊: Inorganic Chemistry
• 影响因子: 4.6
• 作者: Wenger, John S.;Wang, Xiaoping;Johnstone, Timothy C.
• 通讯作者: Johnstone, Timothy C.

A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells

• DOI: 10.1039/d1cc05542a
• 发表时间: 2022-01-28
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Droege, Daniel G.;Johnstone, Timothy C.
• 通讯作者: Johnstone, Timothy C.