Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines

该项目将支持将于2021年1月4日在美国华盛顿特区举行的综合与比较生物学学会（SICB）年会上举行的研讨会“软体动物比较生理学的基因组视角：跨学科整合”。研讨会的演讲者都将强调软体动物是将基因组与表型联系起来的有力手段——这是生物学中一个关键的未解之谜。本次研讨会将汇集来自不同职业阶段和机构以及从生物医学科学到生态学的各种生物学家来讨论这一主题。研讨会活动旨在鼓励参与和促进合作。特别是，研讨会将采用跨学科和互动的模式，为青年科学家提供有意义的专业和科学发展机会。将基因型映射到表型仍然是生物学中最大的挑战之一。对这些反应的遗传基础的机械理解对于预测生命系统如何对快速变化的环境做出反应也至关重要，这对生物学家来说是一个紧迫的挑战。本次研讨会将以对软体动物的兴趣作为共同的货币，将其他完全不同领域（如生物医学、生理学、生态学）的生物学家联系起来。研讨会由11个报告组成，代表了广泛的努力，以整合软体动物生物组织水平的大型数据集，实现将基因组与表型联系起来的更大目标-国家科学基金会确定的重大挑战之一。演讲、讨论和综合将集中在以下主题上：软体动物生命的生物和基因组多样性概述、软体动物高度连续基因组的技术进步、软体动物基因组组装的挑战，以及基因组规模过程如何在多个时空尺度上支撑有机体生理学、生态和进化过程。以生物类群为中心的会议传统上强调系统学和分类学或生物生物学的复杂性。研讨会将明确采取更广泛和更综合的观点，应用生物信息学和基因组学的新见解和发展来解决重要的生物学问题，并解决直接影响人类的健康和经济问题。该奖项由生物科学理事会综合有机体系统部的综合生态生理学和生理机制与生物力学项目共同资助。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

This project will support a symposium, “Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines” that will take place at The Society of Integrative and Comparative Biology (SICB)'s annual meeting on January 4, 2021 in Washington, D.C, USA. The symposium speakers will all highlight mollusks as a powerful means of linking genome to phenotype - a critical unanswered question in biology. This symposium will bring together a diverse set of biologists from across career stages and institutions and from the biomedical sciences to ecology to address this theme. The symposium activities are designed to encourage engagement and catalyze collaborations. In particular, the symposium will use an interdisciplinary and interactive model that will provide meaningful professional and scientific development opportunities for junior scientists. Mapping genotype to phenotype remains one of the biggest challenges in biology. A mechanistic understanding of the genetic basis of these responses is also critically important to forecast how living systems will respond to rapidly changing environments, which represents an urgent challenge for biologists. This symposium will use an interest in mollusks as a common currency to link biologists in otherwise quite disparate fields (e.g., biomedicine, physiology, ecology). The symposium consists of 11 presentations representing a broad range of efforts to integrate large datasets across levels of biological organization in mollusks, towards the larger goal of linking genome to phenome - one of the Grand Challenges identified by NSF. Presentations, discussions and syntheses will focus on topics that include overviews of the biological and genomic diversity of molluscan life, technological progress towards highly contiguous molluscan genomes, challenges in assembling molluscan genomes, and how genome-scale processes underpin organismal physiology and ecological and evolutionary processes over multiple spatiotemporal scales. Meetings focused on organismal groups traditionally emphasize systematics and taxonomy or the intricacies of organismal biology. The symposium will explicitly take a broader and more integrative perspective, applying new insights and developments from bioinformatics and genomics to solve important biological questions and address health and economic issues that directly impact humans.This award was cofunded by the Integrative Ecological Physiology and the Physiological Mechanisms and Biomechanics Programs in the Division of Integrative Organismal Systems in Directorate for Biological Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.