Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines

该项目将支持一个研讨会，“基因组视角在软体动物的比较生理学：跨学科的整合”，这将发生在整合和比较生物学（SICB）的社会年会1月4日，2021年在华盛顿，哥伦比亚特区，美国。研讨会的发言者都将强调软体动物作为一个强大的手段，连接基因组表型-一个关键的生物学悬而未决的问题。本次研讨会将汇集来自不同职业阶段和机构的生物学家，从生物医学科学到生态学，以解决这一主题。研讨会活动旨在鼓励参与和促进合作。特别是，研讨会将采用跨学科和互动模式，为年轻科学家提供有意义的专业和科学发展机会。从基因型到表型的映射仍然是生物学中最大的挑战之一。对这些反应的遗传基础的机械理解对于预测生命系统将如何应对快速变化的环境也至关重要，这对生物学家来说是一个紧迫的挑战。这次研讨会将利用对软体动物的兴趣作为一种共同的货币，将生物学家在其他完全不同的领域（例如，生物医学、生理学、生态学）。该研讨会由11个演讲组成，代表了广泛的努力，以整合软体动物生物组织各级的大型数据集，实现将基因组与表型组联系起来的更大目标-NSF确定的重大挑战之一。演讲，讨论和综合将集中在主题，包括概述的生物和基因组多样性的软体动物的生活，技术进步对高度连续的软体动物基因组，在组装软体动物基因组的挑战，以及如何基因组规模的过程支持生物生理学和生态和进化过程在多个时空尺度。传统上，专注于生物群的会议强调系统学和分类学或生物生物学的复杂性。专题讨论会将明确采取更广泛和更综合的视角，应用生物信息学和基因组学的新见解和发展来解决重要的生物学问题，并解决直接影响人类的健康和经济问题。该奖项由生物科学理事会综合有机系统司的综合生态生理学和生理机制和生物力学项目共同资助。该奖项反映了NSF的法定使命，并已被认为是值得通过使用基金会的智力价值和更广泛的影响审查标准进行评估的支持。

This project will support a symposium, “Genomic Perspectives in Comparative Physiology of Mollusks: Integration across Disciplines” that will take place at The Society of Integrative and Comparative Biology (SICB)'s annual meeting on January 4, 2021 in Washington, D.C, USA. The symposium speakers will all highlight mollusks as a powerful means of linking genome to phenotype - a critical unanswered question in biology. This symposium will bring together a diverse set of biologists from across career stages and institutions and from the biomedical sciences to ecology to address this theme. The symposium activities are designed to encourage engagement and catalyze collaborations. In particular, the symposium will use an interdisciplinary and interactive model that will provide meaningful professional and scientific development opportunities for junior scientists. Mapping genotype to phenotype remains one of the biggest challenges in biology. A mechanistic understanding of the genetic basis of these responses is also critically important to forecast how living systems will respond to rapidly changing environments, which represents an urgent challenge for biologists. This symposium will use an interest in mollusks as a common currency to link biologists in otherwise quite disparate fields (e.g., biomedicine, physiology, ecology). The symposium consists of 11 presentations representing a broad range of efforts to integrate large datasets across levels of biological organization in mollusks, towards the larger goal of linking genome to phenome - one of the Grand Challenges identified by NSF. Presentations, discussions and syntheses will focus on topics that include overviews of the biological and genomic diversity of molluscan life, technological progress towards highly contiguous molluscan genomes, challenges in assembling molluscan genomes, and how genome-scale processes underpin organismal physiology and ecological and evolutionary processes over multiple spatiotemporal scales. Meetings focused on organismal groups traditionally emphasize systematics and taxonomy or the intricacies of organismal biology. The symposium will explicitly take a broader and more integrative perspective, applying new insights and developments from bioinformatics and genomics to solve important biological questions and address health and economic issues that directly impact humans.This award was cofunded by the Integrative Ecological Physiology and the Physiological Mechanisms and Biomechanics Programs in the Division of Integrative Organismal Systems in Directorate for Biological Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.