RAPID: Ionic Modulation of COVID Through Ceramic Surfaces for Deactivation

RAPID：通过陶瓷表面对 COVID 进行离子调制以使其失活

基本信息

批准号：
2031199
负责人：
Ajay Malshe
金额：
$ 15.11万
依托单位：
Purdue University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-15 至 2023-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2031199&HistoricalAwards=false
关键词：
RAPID Ionic Modulation COVID Through

项目摘要

NON-TECHNICAL DESCRIPTION: The goal of this research project is to actively capture and decontaminate surfaces from the COVID-19 virus. This project studies atomically tailored ceramic surface coatings by examining ionic exchange, dielectric properties, and physical texturing. Surface activated ceramic particles are interesting due to their biocompatible nature and effective antigerm activity. The size, shape, and morphology of the particles also impact antigerm responses. The possible mechanisms for antiviral activity include both atomic-scale physical and chemical interactions with the virus' body including spike, coating, and capsid. Chemical interactions include photo-activation of the particles, the formation of reactive oxygen species, and metal ion release, while physical interactions include membrane disruption and mechanical damage to the virus. This research applies advanced indirect and direct techniques to study the interaction of the ceramic with the virus at multiple length scales. This project is especially timely for the protection of multiple surfaces, since the US will reopen in the coming months. The project involves teamwork among scientists, engineers, educators, and industry experts. Training the next generation of the workforce with the ability to grasp the philosophy of convergence is another key outcome of this project.TECHNICAL DETAILS: Coronavirus particles have spike proteins (S-proteins) that are responsible for the attachment to the host cells. Specifically, in humans, the SARS and SARS-CoV-2 species have been shown to interact with the host cell receptor protein ACE2 (a zinc metalloprotein). This virus-cell binding is controlled by the polar interaction between the protein molecules. This research project focuses on using polar ceramic-based structures for the capture and deactivation of the coronavirus. Ionic ceramic solids show intrinsic polarity due to the unique arrangement of atoms across different crystalline facets. For example, the alternate basal planes along [0001] direction contain two separate atoms, which lead to intrinsic polarity. The central hypothesis of this research is that ionic surface defects and the polarity on the surface of ceramic particles benefit the effective capture of coronavirus particles and their subsequent deactivation through ionic modulation. Characterization techniques such as atomic force microscopy (AFM) and transmission electron microscopy (TEM) are being used for the analysis of physical defects. The effect of ionicity on capture and deactivation is being tested via indirect and direct methods. The indirect testing protocol includes inoculation of the surfaces with virus particles and then measuring the number of infectious virus particles. Successful findings are being applied to hard and porous surfaces for aerospace, automotive, retail, and other critical industry sectors.This grant is being awarded using funds made available by the Coronavirus Aid, Relief, and Economic Security (CARES) Act supplement allocated to MPS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

非技术描述：该研究项目的目的是积极捕获和去污染从COVID-19病毒中进行净化。该项目通过检查离子交换，介电特性和物理纹理来研究原子量身定制的陶瓷表面涂层。表面激活的陶瓷颗粒由于其生物相容性和有效的抗抗体活性而有趣。颗粒的大小，形状和形态也会影响抗体反应。抗病毒活性的可能机制包括与病毒体的原子尺度物理和化学相互作用，包括尖峰，涂料和衣壳。化学相互作用包括颗粒的光激活，活性氧的形成以及金属离子释放，而物理相互作用包括膜破坏和对病毒的机械损害。这项研究应用了高级间接技术和直接技术来研究陶瓷与病毒在多个长度尺度上的相互作用。该项目尤其及时保护多个表面，因为美国将在未来几个月内重新开放。该项目涉及科学家，工程师，教育者和行业专家的团队合作。训练下一代劳动力以掌握收敛哲学的能力是该项目的另一个关键结果。技术细节：冠状病毒颗粒具有尖峰蛋白（S蛋白），负责宿主细胞的附着。具体而言，在人类中，已证明SARS和SARS-COV-2物种与宿主细胞受体蛋白ACE2（锌金属蛋白）相互作用。该病毒细胞结合受蛋白质分子之间的极性相互作用控制。该研究项目着重于使用基于极地陶瓷的结构来捕获和停用冠状病毒。离子陶瓷固体由于在不同晶体方面的独特原子排列而显示出内在的极性。例如，沿[0001]方向的替代基平面包含两个单独的原子，这会导致固有的极性。这项研究的中心假设是，陶瓷颗粒表面上的离子表面缺陷和极性有效地捕获了冠状病毒颗粒及其随后通过离子调制而失活。特征技术（例如原子力显微镜（AFM）和透射电子显微镜（TEM））用于分析物理缺陷。离子性对捕获和失活的影响正在通过间接和直接方法进行测试。间接测试方案包括接种带有病毒颗粒的表面，然后测量传染性病毒颗粒的数量。 Successful findings are being applied to hard and porous surfaces for aerospace, automotive, retail, and other critical industry sectors.This grant is being awarded using funds made available by the Coronavirus Aid, Relief, and Economic Security (CARES) Act supplement allocated to MPS.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review 标准。