MRI: Acquisition of a Liquid Chromatograph QToF Mass Spectrometer to Support Research and Training at Hofstra University

霍夫斯特拉大学获得了一份合同，以支持购买一台液相色谱仪四极杆飞行时间质谱仪（LC-MS）和一台氮气发生器。此次收购为拿骚县（人口136万）的一所学术机构带来了第一台高分辨率质谱仪。LC-MS是分离和表征复杂化学和生物分子混合物的重要分析技术，在科学和工程领域有着广泛的应用。该仪器将被纳入霍夫斯特拉大学STEM课程的多个课程，为本科生提供接触这一至关重要的技术的机会。在课堂之外，学生们将在霍夫斯特拉大学和附近的阿德尔菲大学以及纽约州立大学老韦斯特伯里分校通过教师指导的四个学科的研究，接受LC-MS的深入培训。霍夫斯特拉大学及其合作院校通过各种社区外展和支持项目成功招募和培训了不同的学生群体。拥有尖端LC-MS仪器的经验将使学生在就业或攻读STEM领域的研究生课程时受益。新的LC-MS将大大提高生物学、生物化学和生物技术的研究能力。该仪器支持的研究项目多种多样，从研究环境系统中污染物的发生和转化，到表征mRNA运输所必需的RNA/蛋白质复合物的化学修饰。该仪器将用于对多微生物群落的蛋白质输出进行蛋白质组学分析，以及对滩草和葡萄藤的植物-微生物相互作用进行代谢组学分析。它将用于表征新合成的分子，用于研究脂肪酸循环和探索碳-碳键形成的新方法。该仪器还将用于分析干细胞骨分化中的蛋白质衍生化和参与癌症发展的信号网络的去磷酸化。这些研究成果将由学生和教师在科学会议、专题讨论会和同行评议的出版物上传播。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

An award is made to Hofstra University to support the acquisition of a liquid chromatograph quadrupole time-of-flight mass spectrometer (LC-MS) and a nitrogen generator. The acquisition brings the first high-resolution mass spectrometer to an academic institution in Nassau County (Pop: 1.36 million). LC-MS is an important analytical technique for separating and characterizing complex mixtures of chemical and biological molecules, and has broad applications across science and engineering. The instrument will be incorporated into multiple courses in the STEM curriculum at Hofstra University, providing undergraduates with exposure to this crucially important technology. Outside the classroom, students will receive in-depth training in LC-MS through faculty-guided research across four disciplines at Hofstra and nearby Adelphi University and the State University of New York – Old Westbury. Hofstra and its partner institutions successfully recruit and train diverse student bodies through a variety of community outreach and support programs. Experience with cutting edge LC-MS instrumentation will benefit that diverse group of students when they seek employment or pursue graduate studies in STEM fields. The new LC-MS will greatly enhance research capabilities in biology, biochemistry, and biotechnology. Research projects enabled by the instrument vary widely, from studying the occurrence and transformation of pollutants in environmental systems, to characterizing chemical modifications in RNA/protein complexes essential to mRNA transport. The instrument will be used to conduct proteomic analyses of protein export in polymicrobial communities and for metabolomic analyses of plant-microbe interactions of beachgrass and grapevines. It will be used to characterize newly synthesized molecules for studying fatty acid recycling and for investigating new approaches for carbon-carbon bond formation. The instrument will also be used for analyzing protein derivatization in the osteodifferentiation of stem cells and the dephosphorylation of signaling networks involved in cancer development. The results of these research efforts will be disseminated by students and faculty at scientific conferences, symposia, and in peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.