MRI: Acquisition of a Liquid Chromatograph QToF Mass Spectrometer to Support Research and Training at Hofstra University

MRI：采购液相色谱 QToF 质谱仪以支持霍夫斯特拉大学的研究和培训

• 批准号: 2117251
• 负责人: Kevin Bisceglia
• 金额: $ 52.63万
• 依托单位: Hofstra University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2117251&HistoricalAwards=false
• 关键词: MRI; Acquisition; Liquid; Chromatograph; QToF

An award is made to Hofstra University to support the acquisition of a liquid chromatograph quadrupole time-of-flight mass spectrometer (LC-MS) and a nitrogen generator. The acquisition brings the first high-resolution mass spectrometer to an academic institution in Nassau County (Pop: 1.36 million). LC-MS is an important analytical technique for separating and characterizing complex mixtures of chemical and biological molecules, and has broad applications across science and engineering. The instrument will be incorporated into multiple courses in the STEM curriculum at Hofstra University, providing undergraduates with exposure to this crucially important technology. Outside the classroom, students will receive in-depth training in LC-MS through faculty-guided research across four disciplines at Hofstra and nearby Adelphi University and the State University of New York – Old Westbury. Hofstra and its partner institutions successfully recruit and train diverse student bodies through a variety of community outreach and support programs. Experience with cutting edge LC-MS instrumentation will benefit that diverse group of students when they seek employment or pursue graduate studies in STEM fields. The new LC-MS will greatly enhance research capabilities in biology, biochemistry, and biotechnology. Research projects enabled by the instrument vary widely, from studying the occurrence and transformation of pollutants in environmental systems, to characterizing chemical modifications in RNA/protein complexes essential to mRNA transport. The instrument will be used to conduct proteomic analyses of protein export in polymicrobial communities and for metabolomic analyses of plant-microbe interactions of beachgrass and grapevines. It will be used to characterize newly synthesized molecules for studying fatty acid recycling and for investigating new approaches for carbon-carbon bond formation. The instrument will also be used for analyzing protein derivatization in the osteodifferentiation of stem cells and the dephosphorylation of signaling networks involved in cancer development. The results of these research efforts will be disseminated by students and faculty at scientific conferences, symposia, and in peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

霍夫斯特拉大学获得了一项奖励，以支持其购买液相色谱四极杆飞行时间质谱仪（LC-MS）和氮气发生器。此次收购为拿骚县的一家学术机构带来了第一台高分辨率质谱仪（人口：136万）。LC-MS是一种重要的分析技术，用于分离和表征化学和生物分子的复杂混合物，并在科学和工程领域具有广泛的应用。该仪器将被纳入霍夫斯特拉大学STEM课程的多门课程中，为本科生提供接触这一至关重要的技术的机会。 在课堂之外，学生将通过霍夫斯特拉大学和附近的阿德尔菲大学以及纽约-老韦斯特伯里的州立大学的四个学科的教师指导研究接受LC-MS的深入培训。霍夫斯特拉大学及其合作机构通过各种社区外展和支持计划成功地招募和培养了不同的学生团体。尖端LC-MS仪器的经验将使不同群体的学生在寻求就业或攻读STEM领域的研究生课程时受益。 新的LC-MS将大大提高生物学，生物化学和生物技术的研究能力。 该仪器支持的研究项目差异很大，从研究环境系统中污染物的发生和转化，到表征mRNA运输所必需的RNA/蛋白质复合物中的化学修饰。该仪器将用于对多种微生物群落中的蛋白质输出进行蛋白质组学分析，并用于对海草和葡萄藤的植物-微生物相互作用进行代谢组学分析。它将用于表征新合成的分子，用于研究脂肪酸循环和研究碳-碳键形成的新方法。该仪器还将用于分析干细胞骨分化中的蛋白质衍生化和癌症发展中涉及的信号网络的去磷酸化。这些研究工作的结果将由学生和教师在科学会议、研讨会和同行评审的出版物中传播。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的知识价值进行评估而被认为值得支持。影响审查标准。