Organic Transformations of eta-2- Arene Complexes

eta-2-芳烃配合物的有机转化

• 批准号: 9807375
• 负责人: Walter Harman
• 金额: $ 36.25万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9807375&HistoricalAwards=false
• 关键词: Organic; Transformations; eta; Arene; Complexes

The focus of this research is the development of methods to selectively and reversibly dearomatize arenes and polyaromatic hydrocarbons through dihapto-complexation to a transition metal, and to use the resulting adducts as synthons for the preparation of functionalized polycyclic systems. Osmium- and rhenium-based complexing agents will be used to prepare biologically relevant organic molecules. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. W. Dean Harman of the Department of Chemistry at the University of Virginia. Professor Harman will focus his work on developing new methodology that uses transition metals for the activation and functionalization of aromatic molecules. The methodology has potential for the preparation of molecules having importance to the pharmaceutical industry.

本研究的重点是开发方法， 和可逆地脱芳烃和多环芳烃， 与过渡金属的双触配位，并使用所得的 用于制备官能化多环的作为配体的加合物 系统. 基于锇和铼的络合剂将用于 制备生物相关的有机分子。 有了这个更新奖，有机和高分子化学计划 支持W博士的研究。系主任哈曼 弗吉尼亚大学的化学系。 哈曼教授将专注于 致力于开发新的方法， 芳族分子的活化和官能化。 的方法 具有制备对生物学具有重要性的分子的潜力， 医药行业。