Organic Transformations of eta-2- Arene Complexes

eta-2-芳烃配合物的有机转化

• 批准号: 9807375
• 负责人: Walter Harman
• 金额: $ 36.25万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 2001-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9807375&HistoricalAwards=false
• 关键词: Organic; Transformations; eta; Arene; Complexes

The focus of this research is the development of methods to selectively and reversibly dearomatize arenes and polyaromatic hydrocarbons through dihapto-complexation to a transition metal, and to use the resulting adducts as synthons for the preparation of functionalized polycyclic systems. Osmium- and rhenium-based complexing agents will be used to prepare biologically relevant organic molecules. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. W. Dean Harman of the Department of Chemistry at the University of Virginia. Professor Harman will focus his work on developing new methodology that uses transition metals for the activation and functionalization of aromatic molecules. The methodology has potential for the preparation of molecules having importance to the pharmaceutical industry.

本研究的重点是发展通过双合络合得到过渡金属的方法来选择性和可逆地使芳烃和多芳烃脱芳，并利用所得到的加合物作为合成子制备功能化多环体系。锇基和铼基络合剂将用于制备生物相关的有机分子。有了这个更新奖，有机和大分子化学项目支持弗吉尼亚大学化学系的W. Dean Harman博士的研究。哈曼教授将专注于开发利用过渡金属激活和功能化芳香分子的新方法。该方法具有制备对制药工业具有重要意义的分子的潜力。