Organic Transformations of eta-2-Arene Complexes

eta-2-芳烃配合物的有机转化

• 批准号: 0748986
• 负责人: Walter Harman
• 金额: $ 41.4万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-15 至 2011-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0748986&HistoricalAwards=false
• 关键词: Organic; Transformations; eta; Arene; Complexes

This project concerns the continued development of a new paradigm for the activation and functionalization of aromatic molecules. The cornerstone of this project is to selectively bind an arene or polyaromatic hydrocarbon through dihapto-complexation to a transition metal, and to use this adduct as a scaffold for the assembly of new highly-functionalized polycyclic compounds. Coordination serves to enhance the reactivity of the arene toward electrophiles, and to stabilize reactive intermediates (e.g. arenium or allyl cations). In addition, coordination influences the stereochemistry of these chemical transformations, and protects the site of coordination so that it may be used for subsequent chemistry. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor W. Dean Harman of the Department of Chemistry at the University of Virginia. Professor Harman's research efforts revolve around the development of new methods for the activation and functionalization of arenes. The development of such methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.

该项目涉及芳香分子的活化和功能化的新范例的持续发展。 该项目的基石是通过双半络合选择性地将芳烃或多环芳烃结合到过渡金属上，并使用这种加合物作为组装新的高度官能化的多环化合物的支架。 配位用于增强芳烃对亲电体的反应性，并稳定反应性中间体（例如，芳烃或烯丙基阳离子）。 此外，配位影响这些化学转化的立体化学，并保护配位位点，使其可用于后续化学。有了这个奖项，有机和高分子化学计划是支持W教授的研究。弗吉尼亚大学化学系主任哈曼说。 Harman教授的研究工作围绕着芳烃活化和功能化的新方法的开发。 这种方法的发展将对制药和农业工业的合成产生影响。