Organic Transformations of eta-2-Arene Complexes

该项目涉及芳香族分子活化和功能化的新范例的持续发展。这个项目的基础是通过二重络合将芳烃或多芳烃选择性地结合到过渡金属上，并将这种加合物用作组装新的高官能化多环化合物的支架。配位作用是增强芳烃对亲电性的反应性，并稳定活性中间体(例如，芳基或烯丙基阳离子)。此外，配位影响这些化学转换的立体化学，并保护配位位置，以便它可以用于后续的化学。通过这一奖项，有机和高分子化学项目正在支持弗吉尼亚大学化学系W·迪恩·哈曼教授的研究。哈曼教授的研究工作围绕芳烃的活化和功能化新方法的开发展开。这种方法学的发展将对制药和农业中的合成产生影响。

This project concerns the continued development of a new paradigm for the activation and functionalization of aromatic molecules. The cornerstone of this project is to selectively bind an arene or polyaromatic hydrocarbon through dihapto-complexation to a transition metal, and to use this adduct as a scaffold for the assembly of new highly-functionalized polycyclic compounds. Coordination serves to enhance the reactivity of the arene toward electrophiles, and to stabilize reactive intermediates (e.g. arenium or allyl cations). In addition, coordination influences the stereochemistry of these chemical transformations, and protects the site of coordination so that it may be used for subsequent chemistry. With this award, the Organic and Macromolecular Chemistry Program is supporting the research of Professor W. Dean Harman of the Department of Chemistry at the University of Virginia. Professor Harman's research efforts revolve around the development of new methods for the activation and functionalization of arenes. The development of such methodology will have an impact on synthesis in the pharmaceutical and agricultural industries.