Organic Transformations with Dihapto-Coordinated Arene Complexes

双键配位芳烃配合物的有机转化

• 批准号: 0452016
• 负责人: Walter Harman
• 金额: $ 40.5万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0452016&HistoricalAwards=false
• 关键词: Organic; Transformations; Dihapto; Coordinated; Arene

The focus of this research is to develop synthetic methodology using the dihapto-complexation of transition metals to arenes to generate synthons for the assembly of functionalized polycyclics. The use of rhenium, tungsten and molybdenum will be explored and attempts will be made to make this dearomatization methodology catalytic. With this renewal award, the Organic and Macromolecular Chemistry Program is supporting the research of Dr. W. Dean Harman in the Department of Chemistry at the University of Virginia. Professor Harman will focus his work on developing methods for activation and functionalization of aromatic molecules. Selective binding of arenes or polyaromatics to transition metals enhances the reactivity of the aromatic systems towards electrophiles and affords reactive intermediates that can be used for the development of subsequent stereoselective chemistry. Broader impacts are strong in the area of training for both undergraduate and graduate students and the work has significant implications for the pharmaceutical industry.

本研究的重点是发展利用过渡金属与芳烃的双配位反应来合成功能化多环化合物的方法。 将探索钼、钨和钼的使用，并尝试使这种脱芳构化方法催化。 有了这个更新奖，有机和高分子化学计划是支持博士W。弗吉尼亚大学化学系主任哈曼。 Harman教授将专注于开发芳香分子的活化和功能化方法。 芳烃或多环芳烃与过渡金属的选择性结合增强了芳族体系对亲电子试剂的反应性，并提供了可用于后续立体选择性化学发展的反应性中间体。 在本科生和研究生的培训领域，更广泛的影响是强大的，这项工作对制药行业有重大影响。