Organic Transformations with Dihapto-Coordinated Arene Complexes

双键配位芳烃配合物的有机转化

• 批准号: 1152803
• 负责人: Walter Harman
• 金额: $ 47万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1152803&HistoricalAwards=false
• 关键词: Organic; Transformations; Dihapto; Coordinated; Arene

Professor W. Dean Harman of the University of Virginia is supported by the Chemical Synthesis Program in the Division of Chemistry to conduct research that explores the ability of specially designed tungsten complexes, known as dearomatization agents, to coordinate and activate various types of aromatic molecules toward novel chemical transformations. The cornerstone of this approach is the implementation of highly pi-basic transition metal complexes that forms strong back-bonding interactions with the aromatic molecule. The research focuses on three areas: 1) the activation and manipulation of phenols and anilines 2) the activation and manipulation of polyaromatic hydrocarbons and 3) the development of enantio-enriched dearomatization agents that can be used for the synthesis of enantio-enriched organic products derived from aromatic molecules. These new methodologies will be used to generate new organic compounds that will be broad-screened for biological function and medicinal value.New synthetic methods that can convert ubiquitous aromatic molecules into highly functionalized molecules provide facile routes for the preparation of new synthetic substances not readily available from other methods. In most cases, these are entirely new compounds, and are of interest to the biochemical and medicinal communities as potential leads for the development of new biological probes and medicines. The project is highly interdisciplinary, combining elements of coordination chemistry, organometallics, organic, and medicinal chemistries. As a result, Ph. D. and undergraduate students involved with this research will receive the type of broad education required for them to be successful as modern synthetic chemists.

弗吉尼亚大学的 W. Dean Harman 教授在化学系化学合成项目的支持下开展研究，探索专门设计的钨络合物（称为脱芳构剂）协调和激活各种类型芳香族分子进行新型化学转化的能力。这种方法的基石是实施高度π碱性过渡金属络合物，该络合物与芳香族分子形成强的背键相互作用。该研究重点关注三个领域：1）苯酚和苯胺的活化和操作；2）多芳烃的活化和操作；3）开发对映体富集的脱芳构剂，可用于合成源自芳香族分子的对映体富集的有机产品。 这些新方法将用于生成新的有机化合物，这些化合物将在生物功能和药用价值方面进行广泛筛选。新的合成方法可以将普遍存在的芳香族分子转化为高度功能化的分子，为制备其他方法不易获得的新合成物质提供了简便的途径。 在大多数情况下，这些都是全新的化合物，作为开发新生物探针和药物的潜在先导，引起了生物化学和医学界的兴趣。该项目是高度跨学科的，结合了配位化学、有机金属学、有机化学和药物化学的元素。 因此，参与这项研究的博士生和本科生将接受他们成为成功的现代合成化学家所需的广泛教育。