Organic Transformations with eta2-Arene Complexes

eta2-芳烃配合物的有机转化

• 批准号: 9212008
• 负责人: Walter Harman
• 金额: $ 24.46万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212008&HistoricalAwards=false
• 关键词: Organic; Transformations; eta2; Arene; Complexes

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.

当与适当的二触配位剂结合使用时，配位芳烃可以作为各种单环和多环天然产物的有价值的合成子。 为了测试和发展这一假设，该研究计划将解决三个主要问题：i）通过这种技术可以完成哪些传统方法难以实现的有机转化，ii）过渡金属可以在多大程度上控制此类转化的立体化学，以及iii）如何修改络合剂的性质以实现a）芳香底物的更大活化b）不对称诱导和c）催化循环 对于各种目标反应？ %%% 有机合成项目将通过该奖项支持弗吉尼亚大学 W. Dean Harman 博士的研究。 该研究将开发配位芳烃过渡金属配合物形成取代环状产物的反应，该产物具有缩短某些合成序列的作用。 这种新的合成方法应该有利于生物化学和医学以及化学工业的研究。