Organic Transformations with eta2-Arene Complexes

当配位芳烃与适当的双聚配位剂配合使用时，可以作为多种单环和多环天然产物的有价值的合成物。为了检验和发展这一假设，研究计划将解决三个主要问题：I)通过这种技术可以实现哪些传统方法难以实现的有机转化，ii)这种转化的立体化学在多大程度上可以由过渡金属控制，iii)如何修改络合剂的性质，以实现a)芳香底物的更大活化b)不对称诱导，c)各种靶反应的催化循环？有了这笔奖金，有机合成项目将支持弗吉尼亚大学的迪恩·哈曼博士的研究。本研究将发展配位芳烃过渡金属配合物形成取代环产物的反应，具有缩短某些合成序列的作用。这种新的合成方法将有利于生物化学和医学以及化学工业的研究。

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.