Organic Transformations with eta2-Arene Complexes

eta2-芳烃配合物的有机转化

• 批准号: 9212008
• 负责人: Walter Harman
• 金额: $ 24.46万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-07-15 至 1996-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9212008&HistoricalAwards=false
• 关键词: Organic; Transformations; eta2; Arene; Complexes

Coordinated arenes can serve as valuable synthons to a variety of mono-and polycyclic natural products when used in conjunction with an appropriate dihapto-coordination agent. In order to test and develop this hypothesis, the research program will address three primary questions: i) what organic transformations can be accomplished through such a technology that are difficult to achieve by conventional methods, ii) to what extent can the stereochemistry of such transformations be controlled by the transition metal, and iii) how can the nature of the complexing agent be modified to achieve a) greater activation of the aromatic substrate b) asymmetric induction, and c) a catalytic cycle for various target reactions? %%% With this award, the Organic Synthesis Program will support the research of Dr. W. Dean Harman at the University of Virginia. The research will develop the reactions of coordinated arene transition metal complexes to form substituted cyclic products which has the effect of shortening certain synthetic sequences. This new synthetic methodology should benefit research in biochemistry and medicine as well as in the chemical industry.

配位芳烃可以作为各种有价值的载体， 单和多环天然产品， 与适当的双半配位剂结合。 在 为了验证和发展这一假设，研究计划 我将回答三个主要问题：（一）什么是有机？ 通过这种技术可以实现转换 这是传统方法难以实现的，ii） 这种转化的立体化学能达到什么程度 由过渡金属控制，以及iii）自然界如何能够 的络合剂被改性以实现a）更大的 芳香底物的活化B）不对称诱导， 以及c）用于各种目标反应的催化循环？ %%% 有了这个奖项，有机合成计划将支持 W博士的研究弗吉尼亚大学的哈曼院长。 该研究将有助于芳烃配位反应的发展 过渡金属络合物以形成取代的环状产物 其具有缩短某些合成序列的效果。 这种新的合成方法应有利于研究， 生物化学和医学以及化学工业。