NSF Center for the Mechanical Control of Chemistry

NSF 化学机械控制中心

• 批准号: 2303044
• 负责人: James Batteas
• 金额: $ 2000万
• 依托单位: Texas A&M University
• 依托单位国家: 美国
• 项目类别: Cooperative Agreement
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2303044&HistoricalAwards=false
• 关键词: NSF; Center; Mechanical; Control; Chemistry

The NSF Center for the Mechanical Control of Chemistry (CMCC) is an integrative research and training environment that brings together chemists, physicists, and engineers around the common goal of establishing a fundamental understanding of mechanochemistry – the use of mechanical force to drive chemical reactions. Mechanochemistry offers a powerful and versatile means for chemical synthesis, opening the door to new reactions and new materials that cannot be made using traditional synthetic methods. While the effects of light, heat, and electric charge for driving chemical reactions are well understood, the use of mechanical force as a controlling synthetic element is far less developed. To unveil the full potential of mechanochemistry, the CMCC aims to bridge key knowledge gaps between the fields of chemistry and mechanics which have limited the broad application of mechanochemistry as a core synthetic methodology. As mechanochemical reactions can often be carried out with little or no solvent, and at lower temperatures than traditional synthetic approaches, the translation of knowledge in the CMCC from molecular-scale understanding, to large scale syntheses, has the potential for major technological and economic benefits globally, affording more sustainable approaches to the synthesis of chemicals and materials.The CMCC is a coordinated effort among academic, industrial, and national lab partners who are seeking to advance fundamental science which will drive applications in the field of mechanochemistry. Through the development of an Integrated Toolset Program (ITP), the CMCC will advance both experimental and computational tools, establishing fundamental relationships between key reaction parameters and applied forces/stresses. This research aims to develop new chemical reactions and models for predictable mechanochemical syntheses in terms of reaction rates, product yields, and selectivity. These new tools will be applied to advance our understanding of mechanochemical processes for chemical systems ranging from fundamental organic and organometallic reactions (Thrust 1) to solid-state materials, e.g. layered lanthanides, perovskites and metal halides (Thrust 2). The interplay of synergistic activation mechanisms of force with light, heat, and charge is expected to expand understanding of this powerful approach to chemical synthesis. Working with industrial partners, the CMCC seeks to translate this new understanding of force-dependent selectivity and reactivity into new reactor designs, with integrated force control for scale-up. Synergistic research carried out by members of the CMCC has the potential to yield disruptive technologies for the chemical and pharmaceutical industries. To support this sea change, the CMCC will recruit and educate a diverse mechanochemistry workforce. CMCC trainees will be immersed in an inclusive and interdisciplinary environment, benefitting from new curricular developments, exposure to innovation and industrial collaborations, and engagement through extensive informal science communication efforts designed to connect with K-12 and public audiences. This will establish the CMCC as a premier global hub for mechanochemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

NSF化学机械控制中心（CMCC）是一个综合性的研究和培训环境，将化学家，物理学家和工程师聚集在一起，共同目标是建立对机械化学的基本理解-使用机械力驱动化学反应。机械化学为化学合成提供了一种强大而通用的手段，为传统合成方法无法制造的新反应和新材料打开了大门。虽然光、热和电荷对驱动化学反应的影响已经很好地理解，但使用机械力作为控制合成元素的发展要少得多。为了揭示机械化学的全部潜力，CMCC旨在弥合化学和力学领域之间的关键知识差距，这些差距限制了机械化学作为核心合成方法的广泛应用。由于机械化学反应通常可以在很少或没有溶剂的情况下进行，并且温度低于传统的合成方法，因此CMCC中的知识从分子尺度的理解转化为大规模合成，具有全球重大技术和经济效益的潜力，为化学品和材料的合成提供了更可持续的方法。CMCC是学术，工业，和国家实验室合作伙伴，他们正在寻求推进基础科学，这将推动机械化学领域的应用。通过开发综合工具集程序（ITP），CMCC将推进实验和计算工具，建立关键反应参数和作用力/应力之间的基本关系。 本研究的目的是开发新的化学反应和模型，可预测的机械化学合成的反应速率，产品收率和选择性。这些新工具将被应用于推进我们对化学系统机械化学过程的理解，从基本的有机和有机金属反应（推力1）到固态材料，例如层状镧系元素，钙钛矿和金属卤化物（推力2）。力与光、热和电荷的协同激活机制的相互作用有望扩大对这种强大的化学合成方法的理解。CMCC与工业合作伙伴合作，寻求将这种对力依赖选择性和反应性的新理解转化为新的反应器设计，并集成力控制以扩大规模。CMCC成员开展的协同研究有可能为化工和制药行业带来颠覆性技术。为了支持这一巨变，CMCC将招募和教育一支多元化的机械化学工作队伍。CMCC学员将沉浸在一个包容性和跨学科的环境中，受益于新的课程开发，接触创新和行业合作，并通过旨在与K-12和公众观众建立联系的广泛的非正式科学传播工作进行参与。该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。