CAREER: Neuro-navigation guided non-invasive brain stimulation for individualized precision rehabilitation in stroke

职业：神经导航引导的非侵入性脑刺激用于中风的个体化精准康复

• 批准号: 2401215
• 负责人: Yuan Yang
• 金额: $ 59.59万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-10-01 至 2028-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2401215&HistoricalAwards=false
• 关键词: CAREER; Neuro; navigation; guided; non

The goal of this project is to advance the scientific study of brain functional changes after a stroke and pioneer a tailored rehabilitation strategy that fits each individual’s needs. Movement impairments following a stroke are a major cause of adult disability in this country. The routine treatment is not yet optimal for every individual due to a lack of sufficient understanding of brain functional changes to inform clinical practice. This project seeks to combine different imaging methods to guide electrical stimulation to the brain that improves the recovery of movement. The outcomes of this project have the potential to advance stroke or brain injury research broadly to help over half a million people who undergo rehabilitation each year. This will reduce the healthcare and nursing costs for long-term disability caused by stroke and other similar brain injuries. Through education activities in this project, a multi-disciplinary research-education “eco-system” will be built to connect engineering students, clinician trainees, and STEM educators to promote the education of next-generation rehabilitation pioneers. Despite numerous efforts to develop new technologies for movement rehabilitation post-brain injuries, from brain imaging to neuromodulation approaches, optimal recovery is still limited due to a lack of imaging guidance and real-time neurofeedback to tailor rehabilitation strategies for each individual. This project will address this limitation and establish a unique rehabilitation engineering research paradigm based on a novel multi-modal brain imaging approach and a closed-loop high-definition transcranial direct current stimulation (HD-tDCS) platform. This new approach will precisely assess the changes to motor control in an injured brain and identify the key network to target for more precise HD-tDCS stimulation. The investigator will take integrated experimental and computational approaches to: 1) Identify and characterize individualized brain networks for movement control in injured brains; 2) Model and evaluate the dynamic effect of HD-tDCS on a “live” brain to enable targeted, precision stimulation of brain networks; and 3) Develop closed-loop imaging and neurofeedback guided HD-tDCS to improve brain function and behavior outcomes. This interdisciplinary project will be integrated with education and outreach activities to promote awareness of interdependencies between engineering and rehabilitation sciences and promote interdisciplinary education and training for next-generation rehabilitation engineers, with three educational objectives: 1) Promote the engagement of engineering and physical therapy students via summer research training, 2) Translate rehabilitation engineering knowledge to grade-appropriate STEM education via training high school teachers, and 3) Increase public awareness of engineering’s contributions to rehabilitation via museum events.This project is jointly funded by the Disability and Rehabilitation Engineering Program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目的目标是推进中风后大脑功能变化的科学研究，并开创适合每个人需求的定制康复策略。中风后的运动障碍是这个国家成年人残疾的主要原因。由于缺乏对脑功能变化的充分了解，无法为临床实践提供信息，因此常规治疗对每个人来说都不是最佳的。该项目寻求联合收割机不同的成像方法，以引导电刺激大脑，改善运动的恢复。该项目的成果有可能广泛推进中风或脑损伤研究，以帮助每年接受康复治疗的50多万人。这将减少中风和其他类似脑损伤造成的长期残疾的医疗保健和护理费用。通过该项目的教育活动，将建立一个多学科的研究教育“生态系统”，连接工程专业学生，临床实习生和STEM教育工作者，以促进下一代康复先驱的教育。尽管有许多努力来开发用于脑损伤后运动康复的新技术，从脑成像到神经调节方法，但由于缺乏成像指导和实时神经反馈来为每个人定制康复策略，最佳恢复仍然有限。该项目将解决这一限制，并建立一个独特的康复工程研究范式，基于一种新的多模态脑成像方法和闭环高清经颅直流电刺激（HD-tDCS）平台。这种新方法将精确评估受伤大脑中运动控制的变化，并确定关键网络，以实现更精确的HD-tDCS刺激。研究人员将采取综合实验和计算方法来：1）识别和表征用于受伤大脑运动控制的个性化大脑网络; 2）建模和评估HD-tDCS对“活”大脑的动态影响，以实现有针对性的、精确的刺激大脑网络;和3）开发闭环成像和神经反馈引导的HD-tDCS，以改善大脑功能和行为结果。这一跨学科项目将与教育和外联活动相结合，以提高对工程和康复科学之间相互依存关系的认识，并促进下一代康复工程师的跨学科教育和培训，其教育目标有三个：1）通过夏季研究培训促进工程和物理治疗学生的参与，2）通过培训高中教师，将康复工程知识转化为适合年级的STEM教育，和3）通过博物馆活动提高公众对工程学对康复的贡献的认识。该项目由残疾和康复工程联合资助该奖项反映了NSF的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。