Nuclear receptors as regulators of tissue responses and potential targets for anti-fibrotic therapies

核受体作为组织反应的调节剂和抗纤维化治疗的潜在靶标

• 批准号: 258918299
• 负责人: Professor Dr. Jörg Hans Wilhelm Distler
• 金额: --
• 依托单位: Klinik für Rheumatologie
• 依托单位国家: 德国
• 项目类别: Heisenberg Professorships
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/258918299?language=en
• 关键词: Nuclear; receptors; regulators; tissue; responses

The precondition for a Heisenberg Programme funding is high scientific quality and originality of the research project at international level and suitability for further qualification as a university teacher. Applicants need to meet all the requirements for appointment to a permanent professorship.The aim of this programme is to enable outstanding scientists to prepare for a scientific leadership function, and simultaneously work on further research topics. This research does not necessarily need to be planned and carried out in the form of a project.For this reason, and unlike the procedure in other funding programmes, both the abstracts of applications and final reports are not required and will therefore not be published in GEPRIS.

海森堡计划资助的先决条件是高科学质量和国际水平的研究项目的原创性，并适合作为大学教师的进一步资格。申请人需要满足任命为永久教授的所有要求。该计划的目的是使杰出的科学家为科学领导职能做好准备，同时从事进一步的研究课题。这项研究并不一定需要以项目形式规划和进行，因此，与其他资助计划的程序不同，申请摘要和最后报告都不需要，因此不会在GEPRIS上发表。

项目成果

Pomalidomide in Patients with Interstitial Lung Disease due to Systemic Sclerosis: A Phase II, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study

• DOI: 10.3899/jrheum.161040
• 发表时间: 2018-03-01
• 期刊: JOURNAL OF RHEUMATOLOGY
• 影响因子: 3.9
• 作者: Hsu, Vivien M.;Denton, Christopher P.;Hough, Douglas R.
• 通讯作者: Hough, Douglas R.

Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis

• DOI: 10.1111/exd.13180
• 发表时间: 2017-01-01
• 期刊: EXPERIMENTAL DERMATOLOGY
• 影响因子: 3.6
• 作者: Dosoki, Heba;Stegemann, Agatha;Boehm, Markus
• 通讯作者: Boehm, Markus

Increased plasma soluble urokinase plasminogen activator receptor levels in systemic sclerosis: possible association with microvascular abnormalities and extent of fibrosis

• DOI: 10.1515/cclm-2015-0079
• 发表时间: 2015-10-01
• 期刊: CLINICAL CHEMISTRY AND LABORATORY MEDICINE
• 影响因子: 6.8
• 作者: Legany, Nora;Toldi, Gergely;Balog, Attila
• 通讯作者: Balog, Attila

Hippocampal structure and function are maintained despite severe innate peripheral inflammation

• DOI: 10.1016/j.bbi.2015.05.011
• 发表时间: 2015-10
• 期刊: Brain, Behavior, and Immunity
• 作者: P. Süß;L. Kalinichenko;W. Baum;M. Reichel;J. Kornhuber;Sandra Loskarn;Benjamin Ettle;J. Distler

GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways

• DOI: 10.1038/s41467-019-12760-y
• 发表时间: 2019-10-31
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Lopez-Isac, Elena;Acosta-Herrera, Marialbert;Martin, Javier
• 通讯作者: Martin, Javier