Central administration, tissue banking, and clinical translation.

中央管理、组织库和临床翻译。

• 批准号: 264903481
• 负责人: Professor Dr. Lorenz C. Hofbauer
• 金额: --
• 依托单位: Bereich Endokrinologie, Diabetes und Knochenstoffwechselerkrankungen
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2014
• 资助国家: 德国
• 起止时间: 2013-12-31 至 2017-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/264903481?language=en
• 关键词: Central; administration; tissue; banking; clinical

In the first funding period, we have established a tissue microarray with over 400 well-defined prostate cancer samples and performed comprehensive analyses for candidate genes identified in the basic projects (e.g. Wnt5a, Dkk-1). Moreover, a total of four clinicians, Catrin List (Bornhäuser/Wobus, project 1), Tilman Rachner (Hofbauer/Füssel, project 3), Thorsten Heilmann (Trauzold/Kalthoff, project 4 and the Schem group), and Sabrina Kraus (Schütze/Jakob, project 5 and Beilhack, project 9) were funded as clinician-scientists and have produced significant results within the SKELMET research program. One of them (Tilman Rachner) will submit a project proposal as a principal investigator for the second funding period, and two of them (Sabrina Kraus, Thorsten Heilmann) have catalyzed research projects that led to the inclusion of two new PIs, Christian Schem (project 4) and Andreas Beilhack (project 9) in this grant application. For the second funding period, we will further utilize the infrastructure of molecular imaging and tissue banking and continue to train PhD students and postdocs through exchange grants between the four sites and at the labs of international collaborators. In addition, clinical translation will be further emphasized by allocating clinician-scientist positions to the projects in Dresden, Kiel and Würzburg. In addition, we intend to organize coaching and mentoring sessions and scientific retreats, support exchange activities, including the SKELMET homepage (www.skelmet.de), and specifically promote young and female scientists in the upcoming funding period.

在第一个资助期内，我们建立了一个组织芯片，其中包含400多个明确的前列腺癌样本，并对基础项目中确定的候选基因（例如Wnt 5a，Dkk-1）进行了全面分析。此外，共有四名临床医生，Catrin List（Bornhäuser/Wobus，项目1），Tilman Rachner（Hofbauer/Füssel，项目3），Thorsten Heilmann（Trauzold/Kalthoff，项目4和Schem组）和Sabrina Kraus（Schütze/Jakob，项目5和Beilhack，项目9）作为临床科学家获得资助，并在SKELMET研究计划中取得了重要成果。其中一人（Tilman Rachner）将作为第二个资助期的主要研究者提交一份项目提案，其中两人（Sabrina Kraus，Thorsten Heilmann）已经催化了导致两名新PI，Christian Schem（项目4）和Andreas Beilhack（项目9）被纳入本资助申请的研究项目。在第二个资助期，我们将进一步利用分子成像和组织库的基础设施，并继续通过四个地点之间的交换赠款和国际合作者的实验室来培养博士生和博士后。此外，通过为德累斯顿、基尔和维尔茨堡的项目分配临床医生-科学家职位，将进一步强调临床翻译。此外，我们打算组织辅导和指导会议以及科学务虚会，支持交流活动，包括SKELMET主页（www.skelmet.de），并在即将到来的资助期内特别促进年轻和女性科学家。