Central administration, tissue banking, and clinical translation.

在第一个资助期，我们建立了一个组织微阵列，包含400多个明确定义的前列腺癌样本，并对基础项目中确定的候选基因（如Wnt5a， Dkk-1）进行了全面分析。此外，共有四位临床医生，Catrin List (Bornhäuser/Wobus，项目1),Tilman Rachner (Hofbauer/ f<s:1> ssel，项目3),Thorsten Heilmann （Trauzold/Kalthoff，项目4和scheme组）和Sabrina Kraus （sch<e:1> /Jakob，项目5和Beilhack，项目9）作为临床医生和科学家获得资助，并在SKELMET研究计划中取得了重大成果。他们中的一位（Tilman Rachner）将作为第二个资助期的首席研究员提交项目提案，其中两位（Sabrina Kraus, Thorsten Heilmann）催化了两个研究项目，导致两个新的PIs， Christian Schem（项目4）和Andreas Beilhack（项目9）在这个资助申请中被纳入。在第二个资助期，我们将进一步利用分子成像和组织库的基础设施，并通过四个站点之间和国际合作伙伴实验室的交换资助，继续培养博士生和博士后。此外，将进一步强调临床翻译，为德累斯顿、基尔和维尔茨堡的项目分配临床科学家职位。此外，我们打算组织指导和指导会议和科学务静会，支持交流活动，包括SKELMET主页（www.skelmet.de），并在即将到来的资助期内特别推广青年和女性科学家。

In the first funding period, we have established a tissue microarray with over 400 well-defined prostate cancer samples and performed comprehensive analyses for candidate genes identified in the basic projects (e.g. Wnt5a, Dkk-1). Moreover, a total of four clinicians, Catrin List (Bornhäuser/Wobus, project 1), Tilman Rachner (Hofbauer/Füssel, project 3), Thorsten Heilmann (Trauzold/Kalthoff, project 4 and the Schem group), and Sabrina Kraus (Schütze/Jakob, project 5 and Beilhack, project 9) were funded as clinician-scientists and have produced significant results within the SKELMET research program. One of them (Tilman Rachner) will submit a project proposal as a principal investigator for the second funding period, and two of them (Sabrina Kraus, Thorsten Heilmann) have catalyzed research projects that led to the inclusion of two new PIs, Christian Schem (project 4) and Andreas Beilhack (project 9) in this grant application. For the second funding period, we will further utilize the infrastructure of molecular imaging and tissue banking and continue to train PhD students and postdocs through exchange grants between the four sites and at the labs of international collaborators. In addition, clinical translation will be further emphasized by allocating clinician-scientist positions to the projects in Dresden, Kiel and Würzburg. In addition, we intend to organize coaching and mentoring sessions and scientific retreats, support exchange activities, including the SKELMET homepage (www.skelmet.de), and specifically promote young and female scientists in the upcoming funding period.