In situ cross-linking hydrogels for regeneration of cartilage

原位交联水凝胶用于软骨再生

• 批准号: 283823407
• 负责人: Professor Dr. Steffen Fischer
• 金额: --
• 依托单位: Institut für Pflanzen- und Holzchemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2015
• 资助国家: 德国
• 起止时间: 2014-12-31 至 2020-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/283823407?language=en
• 关键词: situ; cross; linking; hydrogels; regeneration

In situ cross-linking hydrogels are useful for minimal invasive treatment of tissue defects and also for controlled release of drugs. The proposal is focused on the hypothesis that semisynthetic sulfated and oxidized polysaccharides based on cellulose and chitosan can be used for generation of hydrogels with tunable mechanical properties, degradation behavior, kinetic of release of growth factor TGF-beta 3 and resulting chondrogenic activity towards mesenchymal stem cells to be applicable for regeneration of cartilage. Beside synthesis of cellulose and chitosan derivatives, characterization of mechanical degradation properties and in vitro studies on bioactivity, also spectroscopic and imaging methods shall be used to analyze mass transfer inside hydrogels, mechanical properties and biocompatibility in vitro and in vivo with a mouse model.

原位交联水凝胶可用于微创治疗组织缺陷，也可用于控制药物释放。该提案的重点假设是，基于纤维素和壳聚糖的半合成硫酸酸化和氧化多糖可用于制备具有可调力学性能、降解行为、生长因子tgf - β 3释放动力学和对间充质干细胞形成软骨活性的水凝胶，从而适用于软骨再生。除了纤维素和壳聚糖衍生物的合成、机械降解性能表征和体外生物活性研究外，还利用光谱和成像方法应使用分析了水凝胶内部的传质、机械性能和生物相容性，并建立了小鼠模型。

项目成果

Effect of Sulfation Route and Subsequent Oxidation on Derivatization Degree and Biocompatibility of Cellulose Sulfates.

硫酸化路线和随后的氧化对硫酸纤维素衍生化程度和生物相容性的影响

• DOI: 10.1002/mabi.201900403
• 发表时间: 2019
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: J. Strätz;A. Liedmann;T. Heinze;S. Fischer;T. Groth
• 通讯作者: T. Groth

Development of hydrogels based on oxidized cellulose sulfates and carboxymethyl chitosan

基于氧化纤维素硫酸盐和羧甲基壳聚糖的水凝胶的开发

• DOI: 10.1007/s10570-019-02596-6
• 发表时间: 2019
• 期刊: Cellulose
• 影响因子: 5.7
• 作者: J. Strätz;A. Liedmann;M.-L. Trutschel;K. Mäder;T. Groth;S. Fischer
• 通讯作者: S. Fischer

Hydrogels Based on Oxidized Cellulose Sulfates and Carboxymethyl Chitosan: Studies on Intrinsic Gel Properties, Stability, and Biocompatibility.

基于氧化纤维素硫酸盐和羧甲基壳聚糖的水凝胶：凝胶固有特性、稳定性和生物相容性研究

• DOI: 10.1002/mabi.202100098
• 发表时间: 2021
• 期刊: Macromolecular bioscience
• 影响因子: 4.6
• 作者: C. Willems;M.-L. Trutschel;V. Mazaikina;J. Strätz;K. Mäder;S. Fischer;T. Groth
• 通讯作者: T. Groth

Synthesis and Characterization of Oxidized Polysaccharides for In Situ Forming Hydrogels

• DOI: 10.3390/biom10081185
• 发表时间: 2020-08-01
• 期刊: BIOMOLECULES
• 影响因子: 5.5
• 作者: Muhammad, Muhammad;Willems, Christian;Groth, Thomas
• 通讯作者: Groth, Thomas

Tailored covalently cross-linked hydrogels based on oxidized cellulose sulfate and carboxymethyl chitosan by targeted adjustment of the storage modulus

通过有针对性地调整储能模量，定制基于氧化纤维素硫酸盐和羧甲基壳聚糖的共价交联水凝胶

• DOI: 10.1007/s10570-020-03279-3
• 发表时间: 2020
• 期刊: Cellulose
• 影响因子: 5.7
• 作者: J. Strätz;S. Fischer
• 通讯作者: S. Fischer