The role of the striatal GABA and glutamate system for the modulation of the congruency sequence effect by perceptual processes: integrating behavior, psychophysiology, and structure-specific neurochemistry

纹状体 GABA 和谷氨酸系统在感知过程调节一致性序列效应中的作用：整合行为、心理生理学和结构特异性神经化学

• 批准号: 422643708
• 负责人: Professor Dr. Christian Beste
• 金额: --
• 依托单位: Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und -psychotherapie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2023-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/422643708?language=en
• 关键词: role; striatal; GABA; glutamate; system

Response selection and control processes are central to cope with the fluctuating environmental demands we encounter. However, response monitoring depends on previous trial history/experience. An example of this phenomenon is the congruency sequence effect (CSE). Several theoretical conceptions have been put forward to explain the CSE. Some of these accounts imply that modulations of perceptual processes should have a strong impact on the CSE. Yet, the specific effects at a psychophysiological level and the question what functional neuroanatomical structures in combination with neurobiological parameters are important to consider are still indeterminate. On the basis of several theoretical considerations, this project examines the role of the striatal GABAergic and glutamatergic system for the modulation of the congruency sequence effect (CSE) by perceptual information (i.e. bottom-up associative processes). To this end, psychophysiological (EEG) methods are combined with structural neurobiochemical methods (magnetic resonance spectroscopy) in different workpackages/experiments manipulating bottom-up (perceptual) associative aspects during the CSE. This allows a comprehensive evaluation and integration of mechanistic factors at a structure-specific neurochemical level with psychophysiology and behavior. The results of the project will provide insights into neural processes underlying the modulation of the CSE by perceptual/sensory processes.

反应选择和控制过程是应对我们遇到的波动的环境需求的核心。然而，反应监测取决于以前的试验历史/经验。这种现象的一个例子是同余序列效应（CSE）。人们提出了几个理论概念来解释CSE。其中一些说法暗示，知觉过程的调节应该对CSE产生强烈的影响。然而，在心理生理水平上的具体影响以及与神经生物学参数相结合的功能神经解剖结构的问题仍然是不确定的。在几个理论考虑的基础上，本项目研究纹状体gaba能和谷氨酸能系统在知觉信息（即自下而上的联想过程）对一致性序列效应（CSE）的调节中的作用。为此，在不同的工作包/实验中，心理生理学（EEG）方法与结构神经生化方法（磁共振波谱）相结合，在CSE期间操纵自下而上（感知）联想方面。这允许在结构特异性神经化学水平与心理生理学和行为的机制因素的综合评估和整合。该项目的结果将为感知/感觉过程调制CSE的神经过程提供见解。