Coordination Funds

协调基金

• 批准号: 319341066
• 负责人: Professor Dr. Michael Hertl
• 金额: --
• 依托单位: Klinik für Dermatologie und Allergologie
• 依托单位国家: 德国
• 项目类别: Research Units
• 财政年份: 2016
• 资助国家: 德国
• 起止时间: 2015-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/319341066?language=en
• 关键词: Coordination; Funds

The Research Group PEGASUS deals with pemphigus, a rare autoimmune disorder of the skin and mucous membranes. Pemphigus is potentially lethal and requires efficient and well-tolerated therapeutic strategies. Moreover, pemphigus is an excellent model disease to better understand autoimmunity in general as the basic mechanisms in the pemphigus pathogenesis are well understood. Our group has been doing research on the immune mechanisms that lead to the formation of pathogenic IgG autoantibodies in pemphigus. A major focus of PEGASUS are T-lymphocytes which in concert with B-lymphocytes lead to the formation of IgG autoantibodies against desmoglein 3, an adhesion molecule in the upper skin (epidermis). In a preclinical mouse model of pemphigus, we try to favorably influence the disease course of pemphigus via inhibition of pathogenic T-cells. These findings will then go directly into the design of clinical trials aimed at improving our understanding which components of the immune system are involved in skin healing and reconstitution of immune tolerance against desmoglein 3 at the same time. Partners of the pemphigus consortium have developed laboratory methods to measure and follow-up on pathogenic immune cells and autoantibodies in pemphigus. Further on, we will study additional factors that are necessary for blister formation of skin and mucous membranes beyond autoantibody binding to skin cells. A hallmark of PEGASUS is the translational research approach, i.e. the direct transfer of experimental findings from the bench to the clinics, either as a clinical trial or improved diagnostic measure. Some of the findings evolving from our pemphigus research may also be applicable to unrelated autoimmune disorders and inflammatory skin disorders.

研究小组Pegasus涉及Pemphigus，Pemphigus是一种罕见的皮肤和粘膜自身免疫性疾病。 Pemphigus可能是致命的，需要有效且耐受良好的治疗策略。此外，Pemphigus是一种出色的模型疾病，可以更好地理解自身免疫性，因为人们对Pemphigus发病机理的基本机制有充分的了解。我们的小组一直在研究导致Pemphigus病原IgG自身抗体形成的免疫机制。飞马的主要重点是T淋巴细胞，它们与B淋巴细胞一致，导致对Desmoglein 3的IgG自身抗体形成，这是上皮肤上的粘附分子（表皮）。在Pemphigus的临床前小鼠模型中，我们试图通过抑制致病性T细胞来有利地影响Pemphigus的疾病。然后，这些发现将直接进入旨在提高我们理解的临床试验的设计，以提高免疫系统的哪些组成部分参与皮肤愈合和重构对Desmoglein 3的免疫耐受性。 Pemphigus联盟的伙伴已经开发了实验室方法，以测量和随访Pemphigus的致病性免疫细胞和自身抗体。此外，我们将研究除了自身抗体与皮肤细胞结合的皮肤和粘膜泡出生所必需的其他因素。 Pegasus的标志是转化研究方法，即作为临床试验或改进的诊断措施将实验发现直接转移到诊所。从我们的Pemphigus研究中演变的一些发现也可能适用于无关的自身免疫性疾病和炎症性皮肤疾病。