リンパ管再生を目的とした軟部組織遺伝子治療方法の開発

淋巴管再生软组织基因治疗方法的开发

• 批准号: 19K10023
• 负责人: 山下 修二
• 金额: $ 2.75万
• 依托单位: Kawasaki Medical School (2022)The University of Tokyo (2019-2021)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K10023/
• 关键词: リンパ管; リンパ管新生; リンパ浮腫; アデノ随伴ウイルスベクター; 遺伝子治療

リンパ浮腫は、がんに対する手術、放射線治療後に高頻度で認められる、無視することのできない医原性後遺症の一つである。再現性、奏効率の高い治療方法は知られておらず、多くの患者が治療を継続、反復しながら生涯にわたる病悩を抱え続ける。将来的な臨床応用の実現性が高く、病態に対して大きな表現型の変化を与えうる介入方法として、本研究ではアデノ随伴ウイルスベクター（AAV）を用いた遺伝子導入によるリンパ管再生の誘導方法を以下の3項目の順に開発する。1) リンパ管内皮細胞特異的な指向性を有するAAVカプシドの開発2) リンパ浮腫動物モデルと、ICG蛍光造影を用いた評価法の確立3) リンパ管再生促進因子の局所導入によるリンパ管再生促進療法の開発

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