The role of PtdIns(4,5)P2 in cellular responses in Saccharomyces cerevisiae.

PtdIns(4,5)P2 在酿酒酵母细胞反应中的作用。

• 批准号: DP0663923
• 负责人: Prof Christina Mitchell
• 金额: $ 17.98万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-03 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0663923
• 关键词: role; PtdIns; P2; cellular; responses

This grant application falls under the criteria of frontier technologies in genomics/phenomics and complex systems. We are characterizing a highly conserved network of signaling molecules regulated by complex large families of enzymes that regulate the bending of membranes, and cellular events including cell division in plants, yeast and mammalian cells. We have developed cutting edge novel technologies to localize signaling on specific intracellular membranes and visualise the role cellular lipids play in forming tubules in cells. This project will result in the presentation of Australian research at international forums and support the training of PhD students.

这项资助申请福尔斯符合基因组学/表型组学和复杂系统前沿技术的标准。我们正在表征一个高度保守的信号分子网络，该网络由复杂的大家族酶调节，这些酶调节膜的弯曲，以及包括植物、酵母和哺乳动物细胞中的细胞分裂在内的细胞事件。我们开发了尖端的新技术，将信号定位在特定的细胞内膜上，并可视化细胞脂质在细胞中形成小管中的作用。该项目将在国际论坛上介绍澳大利亚的研究成果，并支持博士生的培训。