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The role of phosphoinositides in endosomal maturation dynamics.

The role of phosphoinositides in endosomal maturation dynamics.
磷酸肌醇在内体成熟动力学中的作用。
批准号:
DP220103810
负责人:
Prof Christina Mitchell
金额:
$41.77万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2022
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2022-03-01 至 2025-02-28

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中文摘要
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英文摘要
This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.
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Phosphoinositide regulation of lysosome reformation during autophagy
  • 批准号:
    DP190102499
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.36万
  • 财政年份:
    2019
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Regulation of neurite outgrowth by an inhibitor of PI3K signalling.
  • 批准号:
    DP110103655
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $29.56万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Characterization of a novel regulator of angiogenesis
  • 批准号:
    nhmrc : 1010368
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $39.49万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
MTMR4, a regulator of PtdIns(3)P
  • 批准号:
    nhmrc : 545989
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $40.19万
  • 财政年份:
    2009
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
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