The role of phosphoinositides in endosomal maturation dynamics.
The role of phosphoinositides in endosomal maturation dynamics.
批准号:
DP220103810
负责人:
Prof Christina Mitchell
金额:
$41.77万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2022
资助国家:
澳大利亚
项目状态:
未结题
起止时间:
2022-03-01 至 2025-02-28
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This project aims to investigate the regulation of an intracellular compartment within a cell called endosomes, which plays critical roles in cellular homeostasis, signalling and pathogen entry. New knowledge is expected to be generated in understanding endosome maturation and the signalling events that drive this process using a unique, multidisciplinary approach combining state of the art imaging techniques and high throughput protein analysis. The anticipated outcomes will be to define the molecular steps that govern the membrane-bound machinery on endosomes that directs endosomal maturation. This should provide significant benefits in delineating a process that is linked to almost all aspects of cell life.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Phosphoinositide regulation of lysosome reformation during autophagy
-
批准号:DP190102499
-
项目类别:Discovery Projects
-
资助金额:$33.36万
-
财政年份:2019
-
负责人:Prof Christina Mitchell
-
依托单位:
Regulation of neurite outgrowth by an inhibitor of PI3K signalling.
-
批准号:DP110103655
-
项目类别:Discovery Projects
-
资助金额:$29.56万
-
财政年份:2011
-
负责人:Prof Christina Mitchell
-
依托单位:
Characterization of a novel regulator of angiogenesis
-
批准号:nhmrc : 1010368
-
项目类别:NHMRC Project Grants
-
资助金额:$39.49万
-
财政年份:2011
-
负责人:Prof Christina Mitchell
-
依托单位:
MTMR4, a regulator of PtdIns(3)P
-
批准号:nhmrc : 545989
-
项目类别:NHMRC Project Grants
-
资助金额:$40.19万
-
财政年份:2009
-
负责人:Prof Christina Mitchell
-
依托单位:
Regulation of PtdIns(3,4)P2 signalling by inositol polyphosphate 4-phosphatase-1
-
批准号:nhmrc : 491029
-
项目类别:NHMRC Project Grants
-
资助金额:$37.2万
-
财政年份:2008
-
负责人:Prof Christina Mitchell
-
依托单位:
The role of PIPP in cell polarization and proliferation.
-
批准号:nhmrc : 436638
-
项目类别:NHMRC Project Grants
-
资助金额:$35.6万
-
财政年份:2007
-
负责人:Prof Christina Mitchell
-
依托单位:
Characterization of the FHL protein family
-
批准号:nhmrc : 436637
-
项目类别:NHMRC Project Grants
-
资助金额:$34.54万
-
财政年份:2007
-
负责人:Prof Christina Mitchell
-
依托单位:
The role of PtdIns(4,5)P2 in cellular responses in Saccharomyces cerevisiae.
-
批准号:DP0663923
-
项目类别:Discovery Projects
-
资助金额:$17.98万
-
财政年份:2006
-
负责人:Prof Christina Mitchell
-
依托单位:
Characterization of the phosphoinositide 5-phosphatase SKIP.
-
批准号:nhmrc : 384137
-
项目类别:NHMRC Project Grants
-
资助金额:$33.71万
-
财政年份:2006
-
负责人:Prof Christina Mitchell
-
依托单位:
Regulation of myotubularin function by the novel 3-phosphatase adapter protein (3-PAP)
-
批准号:nhmrc : 400080
-
项目类别:NHMRC Project Grants
-
资助金额:$32.56万
-
财政年份:2006
-
负责人:Prof Christina Mitchell
-
依托单位:
The role of the inositol polyphosphate 4-phosphatase in cellular signalling
-
批准号:nhmrc : 334083
-
项目类别:NHMRC Project Grants
-
资助金额:$30.31万
-
财政年份:2005
-
负责人:Prof Christina Mitchell
-
依托单位:
Characterization of the 72 kDa inositol polyphosphate 5-phosphatase
-
批准号:nhmrc : 284273
-
项目类别:NHMRC Project Grants
-
资助金额:$30.28万
-
财政年份:2004
-
负责人:Prof Christina Mitchell
-
依托单位:
The regulation of signalling molecules in Saccharomyces Cerevisiae by inositol polyphosphate 5-phosphatases
-
批准号:DP0345120
-
项目类别:Discovery Projects
-
资助金额:$17.8万
-
财政年份:2003
-
负责人:Prof Christina Mitchell
-
依托单位:
SHIP-2 regulation of the actin cytoskeleton
-
批准号:nhmrc : 236824
-
项目类别:NHMRC Project Grants
-
资助金额:$29.36万
-
财政年份:2003
-
负责人:Prof Christina Mitchell
-
依托单位:
The regulation of PI 3-kinase second messenger molecules, PtdIns(3,4)P2 and PtdIns 3-P.
-
批准号:nhmrc : 194404
-
项目类别:NHMRC Project Grants
-
资助金额:$27.14万
-
财政年份:2002
-
负责人:Prof Christina Mitchell
-
依托单位:
Characterization of 72 and 52 kDa inositol polyphosphate 5-phosphatases: role in vesicular trafficking and cell death
-
批准号:nhmrc : 143540
-
项目类别:NHMRC Project Grants
-
资助金额:$27.21万
-
财政年份:2001
-
负责人:Prof Christina Mitchell
-
依托单位:
CHARACTERISATION OF A NOVEL REGULATOR OF PHOSPHOINOSITIDE 3-KINASE-MEDIATED CELL PROLIFERATION AND PLATELET SIGNALLING
-
批准号:nhmrc : 143542
-
项目类别:NHMRC Project Grants
-
资助金额:$33.35万
-
财政年份:2001
-
负责人:Prof Christina Mitchell
-
依托单位:
Regulation of PtdIns(3,4,5)P3 by inositol polyphosphate 5-phosphatases
-
批准号:nhmrc : 124559
-
项目类别:NHMRC Project Grants
-
资助金额:$13.39万
-
财政年份:2000
-
负责人:Prof Christina Mitchell
-
依托单位:
X-ray crystallography facility (rotating anode generator)
-
批准号:nhmrc : 1593
-
项目类别:NHMRC Infrastructure Grants
-
资助金额:$3.17万
-
财政年份:2000
-
负责人:Prof Christina Mitchell
-
依托单位:
The regulation of PI 3-kinase and 3-position phosphoinositides
-
批准号:nhmrc : 990420
-
项目类别:NHMRC Project Grants
-
资助金额:$20.85万
-
财政年份:1999
-
负责人:Prof Christina Mitchell
-
依托单位:
海外基金