MTMR4, a regulator of PtdIns(3)P

MTMR4，PtdIns(3)P 的调节因子

• 批准号: nhmrc : 545989
• 负责人: Prof Christina Mitchell
• 金额: $ 40.19万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/mtmr4-regulator-ptdins3p/82115
• 关键词: MTMR4; regulator; PtdIns

Normally cells only divide when they receive a stimulus from a hormone or growth factor. The PI3-kinase pathway responds to these stimuli and has been implicated in cellular immunity as well as cancer which occurs when cells divide uncontrollably and invade surrounding tissues. We have identified a putative oncogene (cancer causing gene) called MTMR4 that appears to regulate cell growth-invasion and pathogen invasion of immune cells. We aim to characterise the role of MTMR4 in these systems.

正常情况下，细胞只有在接受激素或生长因子的刺激时才会分裂。PI 3-激酶途径对这些刺激做出反应，并且已经涉及细胞免疫以及当细胞不受控制地分裂并侵入周围组织时发生的癌症。我们已经确定了一个假定的致癌基因（致癌基因）称为MTMR 4，似乎调节细胞生长入侵和免疫细胞的病原体入侵。我们的目标是验证MTMR 4在这些系统中的作用。