MTMR4, a regulator of PtdIns(3)P
MTMR4, a regulator of PtdIns(3)P
批准号:
nhmrc : 545989
负责人:
Prof Christina Mitchell
金额:
$40.19万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2009
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2009-01-01 至 2011-12-31
中文摘要
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英文摘要
Normally cells only divide when they receive a stimulus from a hormone or growth factor. The PI3-kinase pathway responds to these stimuli and has been implicated in cellular immunity as well as cancer which occurs when cells divide uncontrollably and invade surrounding tissues. We have identified a putative oncogene (cancer causing gene) called MTMR4 that appears to regulate cell growth-invasion and pathogen invasion of immune cells. We aim to characterise the role of MTMR4 in these systems.
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Regulation of PtdIns(3,4)P2 signalling by inositol polyphosphate 4-phosphatase-1
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批准号:nhmrc : 491029
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The role of PIPP in cell polarization and proliferation.
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依托单位:
The role of PtdIns(4,5)P2 in cellular responses in Saccharomyces cerevisiae.
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批准号:DP0663923
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Characterization of the phosphoinositide 5-phosphatase SKIP.
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批准号:nhmrc : 400080
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依托单位:
The role of the inositol polyphosphate 4-phosphatase in cellular signalling
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批准号:nhmrc : 334083
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资助金额:$30.31万
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财政年份:2005
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依托单位:
Characterization of the 72 kDa inositol polyphosphate 5-phosphatase
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资助金额:$30.28万
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财政年份:2004
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依托单位:
The regulation of signalling molecules in Saccharomyces Cerevisiae by inositol polyphosphate 5-phosphatases
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批准号:DP0345120
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项目类别:Discovery Projects
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资助金额:$17.8万
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SHIP-2 regulation of the actin cytoskeleton
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财政年份:2003
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The regulation of PI 3-kinase second messenger molecules, PtdIns(3,4)P2 and PtdIns 3-P.
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批准号:nhmrc : 194404
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财政年份:2002
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Characterization of 72 and 52 kDa inositol polyphosphate 5-phosphatases: role in vesicular trafficking and cell death
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财政年份:2001
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CHARACTERISATION OF A NOVEL REGULATOR OF PHOSPHOINOSITIDE 3-KINASE-MEDIATED CELL PROLIFERATION AND PLATELET SIGNALLING
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批准号:nhmrc : 143542
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资助金额:$33.35万
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X-ray crystallography facility (rotating anode generator)
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The regulation of PI 3-kinase and 3-position phosphoinositides
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资助金额:$20.85万
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