Phosphoinositide regulation of lysosome reformation during autophagy

自噬过程中磷酸肌醇对溶酶体重组的调节

• 批准号: DP190102499
• 负责人: Prof Christina Mitchell
• 金额: $ 33.36万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-03-18 至 2022-03-17
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP190102499
• 关键词: Phosphoinositide; regulation; lysosome; reformation; during

This project aims to investigate a new critical step in the autophagy pathway, autophagic lysosome reformation, a fundamental, evolutionarily conserved mechanism for cellular homeostasis. By combining gene function studies with advanced cellular imaging techniques, this project will investigate the dynamic membrane changes that drive this lysosome recycling pathway and how it is regulated by a hierarchical succession of specific enzymes. The expected outcome will be to re-define the archetypical autophagy pathway and characterise novel mechanisms by which it is controlled. This project will reveal new fundamental biological processes, and act as a framework for developing new imaging modalities and tools for studying autophagy.

该项目旨在研究自噬途径中的一个新的关键步骤--自噬溶酶体重组，这是一种基本的、进化上保守的细胞内稳态机制。通过将基因功能研究与先进的细胞成像技术相结合，该项目将研究推动溶酶体循环途径的动态膜变化，以及它是如何被特定酶的分级序列调控的。预期的结果将是重新定义典型的自噬途径，并描述控制自噬的新机制。该项目将揭示新的基本生物学过程，并作为开发研究自噬的新成像模式和工具的框架。