Phosphoinositide regulation of lysosome reformation during autophagy
Phosphoinositide regulation of lysosome reformation during autophagy
批准号:
DP190102499
负责人:
Prof Christina Mitchell
金额:
$33.36万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2019
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2019-03-18 至 2022-03-17
中文摘要
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英文摘要
This project aims to investigate a new critical step in the autophagy pathway, autophagic lysosome reformation, a fundamental, evolutionarily conserved mechanism for cellular homeostasis. By combining gene function studies with advanced cellular imaging techniques, this project will investigate the dynamic membrane changes that drive this lysosome recycling pathway and how it is regulated by a hierarchical succession of specific enzymes. The expected outcome will be to re-define the archetypical autophagy pathway and characterise novel mechanisms by which it is controlled. This project will reveal new fundamental biological processes, and act as a framework for developing new imaging modalities and tools for studying autophagy.
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会议论文
The role of phosphoinositides in endosomal maturation dynamics.
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批准号:DP220103810
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项目类别:Discovery Projects
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资助金额:$41.77万
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财政年份:2022
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负责人:Prof Christina Mitchell
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依托单位:
Regulation of neurite outgrowth by an inhibitor of PI3K signalling.
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批准号:DP110103655
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项目类别:Discovery Projects
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资助金额:$29.56万
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财政年份:2011
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负责人:Prof Christina Mitchell
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依托单位:
Characterization of a novel regulator of angiogenesis
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批准号:nhmrc : 1010368
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项目类别:NHMRC Project Grants
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资助金额:$39.49万
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财政年份:2011
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负责人:Prof Christina Mitchell
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依托单位:
MTMR4, a regulator of PtdIns(3)P
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批准号:nhmrc : 545989
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项目类别:NHMRC Project Grants
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资助金额:$40.19万
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财政年份:2009
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负责人:Prof Christina Mitchell
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依托单位:
Regulation of PtdIns(3,4)P2 signalling by inositol polyphosphate 4-phosphatase-1
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批准号:nhmrc : 491029
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项目类别:NHMRC Project Grants
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资助金额:$37.2万
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财政年份:2008
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负责人:Prof Christina Mitchell
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依托单位:
The role of PIPP in cell polarization and proliferation.
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批准号:nhmrc : 436638
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项目类别:NHMRC Project Grants
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资助金额:$35.6万
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财政年份:2007
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负责人:Prof Christina Mitchell
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依托单位:
Characterization of the FHL protein family
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批准号:nhmrc : 436637
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项目类别:NHMRC Project Grants
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资助金额:$34.54万
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财政年份:2007
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负责人:Prof Christina Mitchell
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依托单位:
The role of PtdIns(4,5)P2 in cellular responses in Saccharomyces cerevisiae.
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批准号:DP0663923
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项目类别:Discovery Projects
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资助金额:$17.98万
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财政年份:2006
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负责人:Prof Christina Mitchell
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依托单位:
Characterization of the phosphoinositide 5-phosphatase SKIP.
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批准号:nhmrc : 384137
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项目类别:NHMRC Project Grants
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资助金额:$33.71万
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财政年份:2006
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负责人:Prof Christina Mitchell
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依托单位:
Regulation of myotubularin function by the novel 3-phosphatase adapter protein (3-PAP)
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批准号:nhmrc : 400080
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项目类别:NHMRC Project Grants
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资助金额:$32.56万
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财政年份:2006
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负责人:Prof Christina Mitchell
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依托单位:
The role of the inositol polyphosphate 4-phosphatase in cellular signalling
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批准号:nhmrc : 334083
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项目类别:NHMRC Project Grants
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资助金额:$30.31万
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财政年份:2005
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负责人:Prof Christina Mitchell
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依托单位:
Characterization of the 72 kDa inositol polyphosphate 5-phosphatase
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批准号:nhmrc : 284273
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项目类别:NHMRC Project Grants
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资助金额:$30.28万
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财政年份:2004
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负责人:Prof Christina Mitchell
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依托单位:
The regulation of signalling molecules in Saccharomyces Cerevisiae by inositol polyphosphate 5-phosphatases
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批准号:DP0345120
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项目类别:Discovery Projects
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资助金额:$17.8万
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财政年份:2003
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负责人:Prof Christina Mitchell
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依托单位:
SHIP-2 regulation of the actin cytoskeleton
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批准号:nhmrc : 236824
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项目类别:NHMRC Project Grants
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资助金额:$29.36万
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财政年份:2003
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负责人:Prof Christina Mitchell
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依托单位:
The regulation of PI 3-kinase second messenger molecules, PtdIns(3,4)P2 and PtdIns 3-P.
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批准号:nhmrc : 194404
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项目类别:NHMRC Project Grants
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资助金额:$27.14万
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财政年份:2002
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负责人:Prof Christina Mitchell
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依托单位:
Characterization of 72 and 52 kDa inositol polyphosphate 5-phosphatases: role in vesicular trafficking and cell death
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批准号:nhmrc : 143540
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项目类别:NHMRC Project Grants
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资助金额:$27.21万
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财政年份:2001
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负责人:Prof Christina Mitchell
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依托单位:
CHARACTERISATION OF A NOVEL REGULATOR OF PHOSPHOINOSITIDE 3-KINASE-MEDIATED CELL PROLIFERATION AND PLATELET SIGNALLING
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批准号:nhmrc : 143542
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项目类别:NHMRC Project Grants
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资助金额:$33.35万
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财政年份:2001
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负责人:Prof Christina Mitchell
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依托单位:
Regulation of PtdIns(3,4,5)P3 by inositol polyphosphate 5-phosphatases
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批准号:nhmrc : 124559
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项目类别:NHMRC Project Grants
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资助金额:$13.39万
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财政年份:2000
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负责人:Prof Christina Mitchell
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依托单位:
X-ray crystallography facility (rotating anode generator)
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批准号:nhmrc : 1593
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项目类别:NHMRC Infrastructure Grants
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资助金额:$3.17万
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财政年份:2000
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负责人:Prof Christina Mitchell
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依托单位:
The regulation of PI 3-kinase and 3-position phosphoinositides
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批准号:nhmrc : 990420
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项目类别:NHMRC Project Grants
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资助金额:$20.85万
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财政年份:1999
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负责人:Prof Christina Mitchell
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依托单位:
国内基金
海外基金
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