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Regulation of PtdIns(3,4)P2 signalling by inositol polyphosphate 4-phosphatase-1

Regulation of PtdIns(3,4)P2 signalling by inositol polyphosphate 4-phosphatase-1
肌醇多磷酸 4-磷酸酶-1 对 PtdIns(3,4)P2 信号传导的调节
批准号:
nhmrc : 491029
负责人:
Prof Christina Mitchell
金额:
$37.2万
依托单位:
依托单位国家:
澳大利亚
项目类别:
NHMRC Project Grants
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31

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中文摘要
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英文摘要
Normally cells only divide when they receive a stimulus such as from a hormone or growth factor. One of the signaling pathways which responds to growth factor stimulation is the PI3-kinase pathway. This pathway has been implicated in many different human cancers which occur when cells divide uncontrollably and invade into the surrounding tissues. We have idenitified a novel enzyme called the inositol polyphosphate 4-phosphatase that appears to regulate cell proliferation and differentiation.
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会议论文
The role of phosphoinositides in endosomal maturation dynamics.
  • 批准号:
    DP220103810
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $41.77万
  • 财政年份:
    2022
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Phosphoinositide regulation of lysosome reformation during autophagy
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    DP190102499
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $33.36万
  • 财政年份:
    2019
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Regulation of neurite outgrowth by an inhibitor of PI3K signalling.
  • 批准号:
    DP110103655
  • 项目类别:
    Discovery Projects
  • 资助金额:
    $29.56万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
Characterization of a novel regulator of angiogenesis
  • 批准号:
    nhmrc : 1010368
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $39.49万
  • 财政年份:
    2011
  • 负责人:
    Prof Christina Mitchell
  • 依托单位:
国内基金
海外基金
自噬PtdIns3K复合物辅助亚基NRBF2调控成体海马神经发生在抑郁症中的作用及机制
  • 批准号:
    82273912
  • 项目类别:
    面上项目
  • 资助金额:
    52万元
  • 批准年份:
    2022
  • 负责人:
    胡壮丽
  • 依托单位:
中枢神经元膜脂PtdIns(4)P在突触后蛋白囊泡运输中的功能研究