Novel intestinal anti-inflammatory therapies by regulating adhesion molecule transport by the CUL3 ubiquitin ligase.

通过 CUL3 泛素连接酶调节粘附分子转运的新型肠道抗炎疗法。

• 批准号: 18K15822
• 负责人: ozeki Keiji
• 金额: $ 2.66万
• 依托单位: Nagoya City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Early-Career Scientists
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18K15822/
• 关键词: 炎症性腸疾患; 接着分子; インテグリン; 細胞接着因子; cullin3; 難治性炎症性腸疾患; Cullin3; CUL3ユビキチンE3リガーゼタンパク質; 血管内皮細胞; BTB-ZnF ドメイン蛋白; CUL3ユビキチンリガーゼ

项目成果

Combination Therapy With Tofacitinib Plus Intensive Granulocyte and Monocyte Adsorptive Apheresis as Induction Therapy for Refractory Ulcerative Colitis.

• DOI: 10.14740/jocmr4037
• 发表时间: 2020-01-01
• 期刊: Journal of clinical medicine research
• 作者: Tanida, Satoshi;Ozeki, Keiji;Kataoka, Hiromi
• 通讯作者: Kataoka, Hiromi

5-aminolaevulinic acid (5-ALA) accumulates in GIST-T1 cells and photodynamic diagnosis using 5-ALA identifies gastrointestinal stromal tumors (GISTs) in xenograft tumor models.

• DOI: 10.1371/journal.pone.0249650
• 发表时间: 2021
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Sasaki M;Tanaka M;Ichikawa H;Suzuki T;Nishie H;Ozeki K;Shimura T;Kubota E;Tanida S;Kataoka H
• 通讯作者: Kataoka H

Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer

曲妥珠单抗联合 S-1 和奥沙利铂 (SOX100) 治疗 HER2 阳性晚期胃癌的 II 期前瞻性研究

• DOI: 10.1007/s12029-021-00711-0
• 发表时间: 2022
• 期刊: J Gastrointest Cancer
• 作者: Mori Y;Kataoka H;Ebi M;Adachi K;Yamaguchi Y;Hayashi N;Hirata Y;Sobue S;Ishihara R;Suzuki Y;Mizushima T;Inoue Y;Hasegawa I;Ono S;Hirano A;Kimura Y;Seno K;Ozeki K;Shimura T;Kubota E.
• 通讯作者: Kubota E.

Serum Exosomal Dicer Is a Useful Biomarker for Early Detection of Differentiated Gastric Adenocarcinoma

血清外泌体 Dicer 是早期检测分化型胃腺癌的有用生物标志物

• DOI: 10.1159/000510993
• 发表时间: 2020
• 期刊: Digestion.
• 作者: Okuda Y;Shimura T;Iwasaki H;Katano T;Kitagawa M;Nishigaki R;Fukusada S;Natsume M;Tanaka M;Nishie H;Ozeki K;Yamada T;Kataoka H.
• 通讯作者: Kataoka H.