Modular, IC-based arrays for broadband NMR-based metabolite screeening

基于 IC 的模块化阵列，用于基于宽带 NMR 的代谢物筛选

• 批准号: 389084717
• 负责人: Professor Dr. Jens Anders
• 金额: --
• 依托单位: Institut für Mikrostrukturtechnik (IMT)
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2018
• 资助国家: 德国
• 起止时间: 2017-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/389084717?language=en
• 关键词: Modular; IC; based; arrays; broadband

The long term vision of screeMR is to perform the necessary research to be able to remove the instrumentation related limitations of MR based metabolite screening, which will allow researchers in the field to fully benefit from the intrinsic advantages of MR spectroscopy over competing methods, including its unmatched specificity and complete noninvasiveness.To proceed towards our long term vision, screeMR will tackle the key limitations of existing MR screening hardware by utilizing advanced cleanroom manufacturing techniques in combination with integrated circuit technologies. This approach will allow us to research new modular concepts for large-scale MR coil arrays with significant advantages compared to state-of-the-art systems. To achieve modularity, a thorough theoretical investigation of small sets of coupled MR detectors will be carried out, especially with respect to the preconditions of all MR experiments, namely sensitivity and spectral linewidth, in order to identify suitable concepts for modular building blocks of even larger MR detector arrays.Based on these theoretical considerations we will combine advanced, very scalable cleanroom manufacturing processes and nanometer-scaled IC technologies, to achieve functional hardware prototypes of the most promising modular building block candidates. The use of custom-designed ASICs will be one of the key enablers for the envisioned modular MR platform because, apart from the fact that it provides the required electrical performance at a suitable form factor and power consumption, it provides probably the only solution which can operate inside the high magnetic field strengths >10 T of NMR spectrometers with very small chip-to-coil-distances, which are required for a broadband operation without problems associated with reflections on long cable interconnects.Overall, through theoretical investigations and subsequent miniaturized and scalable hardware implementations, which make consequent use of cleanroom manufacturing and integrated circuit technologies, the proposed project will pave the way towards future MR based reliable, high-throughput, high-sensitivity, nondestructive and noninvasive metabolomic studies of biological systems. Therefore, on a medium time-scale, by largely speeding up the throughput of MR-based analytics while preserving its unmatched specificity, the findings of the proposed project aim to completely remove the need for current expensive hyphenated screening methods, which are presenting the state-of-the-art today. With this achieved, the reduced complexity and cost associated with screening experiments will make it an attractive solution for a much larger range of applications than is imaginable today.

screeMR的长期愿景是进行必要的研究，以便能够消除基于MR的代谢物筛选的仪器相关限制，这将使该领域的研究人员充分受益于MR波谱技术相对于竞争方法的内在优势，包括其无与伦比的特异性和完全的无创性。为了实现我们的长期愿景，screeMR将通过利用先进的洁净室制造技术与集成电路技术相结合，解决现有MR筛查硬件的关键局限性。这种方法将使我们能够研究新的模块化概念的大型MR线圈阵列具有显着的优势相比，国家的最先进的系统。为了实现模块化，将对小组耦合MR探测器进行彻底的理论研究，特别是关于所有MR实验的前提条件，即灵敏度和谱线宽度，以便确定用于更大MR探测器阵列的模块化构建块的合适概念。基于这些理论考虑，我们将联合收割机结合先进的，可扩展性极强的洁净室制造工艺和纳米级IC技术，以实现最有前途的模块化构建块候选者的功能硬件原型。使用定制设计的ASIC将是所设想的模块化MR平台的关键推动因素之一，因为除了它以合适的形状因子和功耗提供所需的电气性能之外，它可能提供了唯一的解决方案，该解决方案可以在具有非常小的芯片到线圈距离的NMR光谱仪的>10 T的高磁场强度内操作，总的来说，通过理论研究和随后的小型化和可扩展的硬件实现，其随后使用洁净室制造和集成电路技术，所提出的项目将为未来基于MR的可靠，生物系统的高通量、高灵敏度、非破坏性和非侵入性代谢组学研究。因此，在中等时间范围内，通过大大加快基于MR的分析的吞吐量，同时保持其无与伦比的特异性，拟议项目的研究结果旨在完全消除对当前昂贵的联用筛选方法的需求，这些方法目前正在呈现最先进的技术。实现这一点后，与筛选实验相关的复杂性和成本降低将使其成为一个有吸引力的解决方案，适用于比今天想象的更大范围的应用。