Modular, IC-based arrays for broadband NMR-based metabolite screeening

screenemr的长期愿景是进行必要的研究，以消除基于MR代谢物筛选的仪器相关限制，这将使该领域的研究人员充分受益于MR光谱相对于竞争方法的内在优势，包括其无与伦比的特异性和完全的无创性。为了实现我们的长期愿景，screenemr将利用先进的洁净室制造技术与集成电路技术相结合，解决现有MR筛选硬件的关键限制。这种方法将使我们能够研究大规模MR线圈阵列的新模块化概念，与最先进的系统相比具有显着优势。为了实现模块化，将对小组耦合磁共振探测器进行彻底的理论研究，特别是关于所有磁共振实验的先决条件，即灵敏度和谱线宽度，以便为更大的磁共振探测器阵列的模块化构建块确定合适的概念。基于这些理论考虑，我们将结合先进的、非常可扩展的洁净室制造工艺和纳米级集成电路技术，以实现最有前途的模块化候选模块的功能硬件原型。使用定制设计的asic将是设想的模块化MR平台的关键推动因素之一，因为除了它在合适的外形尺寸和功耗下提供所需的电气性能之外，它可能提供了唯一的解决方案，可以在非常小的芯片到线圈距离的高磁场强度bbb10 T的NMR光谱仪内工作。这是宽带操作所必需的，没有与长电缆互连反射相关的问题。总的来说，通过理论研究和随后的小型化和可扩展的硬件实现，从而利用洁净室制造和集成电路技术，拟议的项目将为未来基于MR的可靠，高通量，高灵敏度，非破坏性和非侵入性的生物系统代谢组学研究铺平道路。因此，在中等时间尺度上，通过在很大程度上加快基于核磁共振的分析的吞吐量，同时保持其无与伦比的特异性，拟议项目的研究结果旨在完全消除当前昂贵的连线筛选方法的需求，这些方法是当今最先进的。实现了这一点，与筛选实验相关的复杂性和成本的降低将使其成为比今天想象的更大范围应用的有吸引力的解决方案。

The long term vision of screeMR is to perform the necessary research to be able to remove the instrumentation related limitations of MR based metabolite screening, which will allow researchers in the field to fully benefit from the intrinsic advantages of MR spectroscopy over competing methods, including its unmatched specificity and complete noninvasiveness.To proceed towards our long term vision, screeMR will tackle the key limitations of existing MR screening hardware by utilizing advanced cleanroom manufacturing techniques in combination with integrated circuit technologies. This approach will allow us to research new modular concepts for large-scale MR coil arrays with significant advantages compared to state-of-the-art systems. To achieve modularity, a thorough theoretical investigation of small sets of coupled MR detectors will be carried out, especially with respect to the preconditions of all MR experiments, namely sensitivity and spectral linewidth, in order to identify suitable concepts for modular building blocks of even larger MR detector arrays.Based on these theoretical considerations we will combine advanced, very scalable cleanroom manufacturing processes and nanometer-scaled IC technologies, to achieve functional hardware prototypes of the most promising modular building block candidates. The use of custom-designed ASICs will be one of the key enablers for the envisioned modular MR platform because, apart from the fact that it provides the required electrical performance at a suitable form factor and power consumption, it provides probably the only solution which can operate inside the high magnetic field strengths >10 T of NMR spectrometers with very small chip-to-coil-distances, which are required for a broadband operation without problems associated with reflections on long cable interconnects.Overall, through theoretical investigations and subsequent miniaturized and scalable hardware implementations, which make consequent use of cleanroom manufacturing and integrated circuit technologies, the proposed project will pave the way towards future MR based reliable, high-throughput, high-sensitivity, nondestructive and noninvasive metabolomic studies of biological systems. Therefore, on a medium time-scale, by largely speeding up the throughput of MR-based analytics while preserving its unmatched specificity, the findings of the proposed project aim to completely remove the need for current expensive hyphenated screening methods, which are presenting the state-of-the-art today. With this achieved, the reduced complexity and cost associated with screening experiments will make it an attractive solution for a much larger range of applications than is imaginable today.